How is cumulative medical imaging in childhood associated with cancer risk? NEJM Editorial Fellow Katerina Lin, MD, summarizes a recent retrospective cohort study involving 3 million children. Read the full study: https://www.nejm.org/doi/full/10.1056/NEJMoa2502098
Among patients with atherosclerotic cardiovascular disease, targeting an LDL cholesterol level below 55 mg per deciliter led to a lower 3-year risk of cardiovascular events than targeting a level below 70 mg per deciliter. Full Ez-PAVE trial results and Research Summary: https://www.nejm.org/doi/full/10.1056/NEJMoa2600283
A 27-year-old woman presented with a 2-week history of joint pain, fever, sore throat, and a nonpruritic rash that worsened during febrile episodes. Read the full case details and submit your answer or see how others responded: https://www.nejm.org/image-challenge?ci=20260409
Efforts toward Equity by Elizabeth I. Ackley, PhD: Leveraging School Systems as Data Partners to Advance Health Equity https://www.nejm.org/doi/full/10.1056/NEJMp2516497
#PublicHealth
Available therapies for immune thrombocytopenia are ineffective in some patients. Research evaluating mezagitamab is summarized in a new Quick Take video. https://www.nejm.org/do/10.1056/NEJMdo008439/full/
In a phase 1 trial of setidegrasib, a KRAS G12D degrader, 42% of patients had adverse events of grade 3 or higher; 36% of patients with NSCLC and 24% of those with pancreatic cancer had a response. Full trial results: https://www.nejm.org/doi/full/10.1056/NEJMoa2600752
#Oncology #Gastroenterology
Original Article: Multifaceted Strategies for Hypertension Control in Low-Income Patients (IMPACTS-BP trial) https://www.nejm.org/doi/full/10.1056/NEJMoa2504068
Editorial: Systems-Based Success for Hypertension https://www.nejm.org/doi/full/10.1056/NEJMe2518341
#Cardiology
A 68-year-old man who had undergone intubation 25 days earlier had difficulty swallowing after extubation. A swallowing study showed fluid penetrating into the trachea without triggering a cough reflex (shown in a video).
Read the full case details in the Images in Clinical Medicine article “Silent Aspiration”: https://www.nejm.org/doi/full/10.1056/NEJMicm2516115
The NYC Health Department (@nycHealthy) hosted two symposia for students, faculty, and health professionals to launch ongoing learning about the harms of race essentialism, racial biases, and systemic racism. Learn more in a new Perspective, part of the Efforts toward Equity series: https://www.nejm.org/doi/full/10.1056/NEJMp2602091
Figure 2 from a new Clinical Practice article by Joseph A. Murray, MD, and Steffen Husby, MD, DMSc, shows a flowchart for the diagnosis of celiac disease. Read the full article to learn more about the epidemiology, diagnosis, and management of the disease: https://www.nejm.org/doi/full/10.1056/NEJMcp2415548
Danielle D. Jones, PhD, MPH, discusses the development of tools to help family physicians address social determinants of health and advance health equity. Listen to the full interview with NEJM Executive Managing Editor Stephen Morrissey (@srm128): https://www.nejm.org/doi/full/10.1056/NEJMdo008488
𝐍𝐨𝐰 𝐚𝐯𝐚𝐢𝐥𝐚𝐛𝐥𝐞 𝐢𝐧 𝑵𝑬𝑱𝑴 𝑬𝒗𝒊𝒅𝒆𝒏𝒄𝒆!
A new Public Health Alerts report, published in partnership with @CIDRAP: Emergence of Medetomidine in New York’s Illicit Drug Supply https://eviden.cc/4tCd1RC
#InfectiousDisease
IMPACTS-BP trial: Uncontrolled hypertension is a leading cause of health disparities. Research on whether a multifaceted, team-based implementation strategy can improve outcomes in resource-constrained primary care settings is summarized in a new Quick Take video. https://www.nejm.org/doi/full/10.1056/NEJMdo008437
A 27-year-old woman presented with a 2-week history of joint pain, fever, sore throat, and a nonpruritic rash that worsened during febrile episodes. Physical examination was notable for generalized lymphadenopathy and swelling of the wrists, knees, and ankles. Laboratory studies showed neutrophilic leukocytosis, an elevated C-reactive protein level and erythrocyte sedimentation rate, and ferritin level of 4053 μg per liter (reference range, 10 to 200). An antinuclear antibody was negative. What is the most likely diagnosis? https://www.nejm.org/image-challenge?ci=20260409
The authors of a new Perspective write that Asian Health Services in Alameda County, California, conducted a multifaceted project to address the low rates of access to and use of digital diabetes technologies in marginalized populations. Read the full Perspective, part of the Efforts toward Equity series: https://www.nejm.org/doi/full/10.1056/NEJMp2516041
A new Double Take video explores how a comprehensive patient-centered approach can provide high-value care for older patients. Watch “The Whole Patient — Toward Holistic, High-Value Care” on YouTube: https://youtu.be/GXUr5NtzanU
Findings from an analysis of deidentified electronic health record data from a national database indicate that the prevalence of youth-onset type 2 diabetes has increased substantially during the past decade. Full study results: https://www.nejm.org/doi/full/10.1056/NEJMc2507615
A study in a mouse model of 𝘔𝘠𝘊𝘕-amplified neuroblastoma implicates polyamine levels in affecting the makeup of the proteome and biologic characteristics of the tumor.
Learn more in the Clinical Implications of Basic Research article “Altering the Diet to Rewire Cancer” by Michelle Haber, PhD, and Murray D. Norris, PhD, from Children's Cancer Institute (@KidsCancerInst) and the School of Clinical Medicine at the University of New South Wales Sydney: https://www.nejm.org/doi/full/10.1056/NEJMcibr2516825
A critical issue is coming into focus as AI becomes further embedded in clinical decision-making: different AI models consistently prioritize clinical decisions in unique ways — and those differences impact patients, clinicians, and organizations alike. Join @NEJM_AI for its next event on one of the most urgent discussions in clinical AI. Learn more and sign up: https://events.nejm.org/events/803?promo=OAFYX422&query=nejm-social&utm_source=x&utm_medium=social&utm_campaign=2026_aievent422
A survey of the NEJM Catalyst (@nejmcatalyst) Insights Council finds that patient hesitancy is the top challenge, especially in the United States, for health care organizations’ vaccination programs. U.S. Council members lack confidence in public health agencies’ ability to support vaccination efforts.
Learn more in the Insights Report “Clinician Trust in Vaccines Is Countered by Patient Hesitancy” by Priya Sampathkumar, MD (@PSampathkumarMD), in the April issue of @nejmcatalyst Innovations in Care Delivery: https://catalyst.nejm.org/doi/full/10.1056/CAT.26.0107
Explore the full issue: https://catalyst.nejm.org/toc/catalyst/7/4
Original Article: Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease (Ez-PAVE trial) https://www.nejm.org/doi/full/10.1056/NEJMoa2600283
Editorial: Paving the Road toward Targeted Lipid Lowering https://www.nejm.org/doi/full/10.1056/NEJMe2601725
#Cardiology
A 57-year-old man with a 3-day history of vomiting and progressive confusion was brought to the ED by his wife. He reported generalized weakness and difficulty speaking and swallowing but no headache or fever. Read the full case details: https://www.nejm.org/doi/full/10.1056/NEJMcps2510060
In a new Perspective, Elizabeth I. Ackley, PhD, writes that a collaboration between a college and a public school system centers young people’s health outcomes and considers family perceptions of neighborhood conditions as drivers of health-focused community development. Learn more: https://www.nejm.org/doi/full/10.1056/NEJMp2516497
Case Record of the Massachusetts General Hospital (@MassGeneralNews): A 70-year-old woman was evaluated at this hospital because of a racing heart, fatigue, dyspnea, and leg edema.
Five months before the current admission, the patient was evaluated by a cardiologist at this hospital for frequent episodes of palpitations and lightheadedness that did not resolve with cessation of alcohol and caffeine use. Outpatient rhythm monitoring showed paroxysmal atrial tachycardia and atrial fibrillation events that constituted a total tachycardia burden of 6%, with heart rates of up to 180 beats per minute. Treatment with apixaban and flecainide was started; however, the symptoms did not abate, and flecainide was discontinued.
Read the full case details in “A 70-Year-Old Woman with a Racing Heart, Fatigue, and Dyspnea,” a Case Record of the Massachusetts General Hospital, by T.K. Varghese et al., from Huntsman Cancer Institute, University of Utah School of Medicine, Massachusetts General Hospital (@MassGeneralNews), and @harvardmed: https://www.nejm.org/doi/full/10.1056/NEJMcpc2513542
#AFib #Cardiology
New in the April 9, 2026, issue of NEJM:
Intensive LDL Cholesterol Targeting (Ez-PAVE trial) https://www.nejm.org/doi/full/10.1056/NEJMoa2600283
Hypertension Control in Low-Income Patients (IMPACTS-BP trial) https://www.nejm.org/doi/full/10.1056/NEJMoa2504068
Mezagitamab in Primary Immune Thrombocytopenia https://www.nejm.org/doi/full/10.1056/NEJMoa2513120
Immunogenicity and Safety of a Yellow Fever Vaccine https://www.nejm.org/doi/full/10.1056/NEJMoa2505665
Setidegrasib in Advanced NSCLC and Pancreatic Cancer https://www.nejm.org/doi/full/10.1056/NEJMoa2600752
Subscribe to NEJM for the latest medical research: https://store.nejm.org/nejm/subscribe/choice
An 83-year-old woman with worsening type 2 diabetes presented with a 6-month history of painful rash. Hyperpigmented plaques with coalescing erosions and blisters were seen. Abdominal CT revealed a mass in the tail of the pancreas.
Read the full case details in the Images in Clinical Medicine article “Necrolytic Migratory Erythema”: https://www.nejm.org/doi/full/10.1056/NEJMicm2516331
The authors of a new Perspective write that recognizing that family physicians face obstacles to addressing social determinants of health, the American Academy of Family Physicians (@aafp) developed a set of practical tools to enhance community–clinical linkages and advance health equity. Read the full Perspective, part of the Efforts toward Equity series: https://www.nejm.org/doi/full/10.1056/NEJMp2509686
A new article summarizes the epidemiology, diagnosis, and management of celiac disease and highlights serologic testing, biopsy confirmation, associated autoimmune conditions, and a gluten-free diet as treatment.
Read the Clinical Practice article “Celiac Disease” by Joseph A. Murray, MD, and Steffen Husby, MD, DMSc, from @mayoclinic and the University of Southern Denmark: https://www.nejm.org/doi/full/10.1056/NEJMcp2415548
In a phase 2 trial, a new yellow fever vaccine grown in Vero cells was shown to elicit immunogenicity similar to that of the standard yellow fever vaccine. Full trial results: https://www.nejm.org/doi/full/10.1056/NEJMoa2505665
Among adults with persistent or chronic ITP, the incidence of adverse events with mezagitamab appeared to be similar to that with placebo. Mezagitamab treatment appeared to result in increased platelet counts at all three doses tested. Full trial results: https://www.nejm.org/doi/full/10.1056/NEJMoa2513120
Among low-income patients with hypertension, a multifaceted, team-based strategy resulted in a greater reduction in systolic blood pressure than enhanced usual care. Full IMPACTS-BP trial results: https://www.nejm.org/doi/full/10.1056/NEJMoa2504068
Editorial: Systems-Based Success for Hypertension https://www.nejm.org/doi/full/10.1056/NEJMe2518341
Correspondence: Simulating and Teaching the Physiology of Pulsus Paradoxus https://www.nejm.org/doi/full/10.1056/NEJMc2518685
#Cardiology
For a patient with acute liver failure on a background of alcohol-associated cirrhosis, would you recommend liver transplantation or continue medical intensive care management alone? Vote on the best option: https://www.nejm.org/doi/full/10.1056/NEJMclde2506067
Two articles from @NEJMEvidence that made news last month:
1️⃣ Wrist Splinting versus a Placebo Soft Bandage for Carpal Tunnel Syndrome https://eviden.cc/4rFztrz
Covered in @medpagetoday: Tried-and-True Carpal Tunnel Treatment Flops in Controlled Trial https://eviden.cc/47IKu4u
Among patients with a preserved ejection fraction at least 1 year after myocardial infarction, stopping beta-blockers was noninferior to continuing therapy with respect to major clinical outcomes. Full SMART-DECISION trial results and Research Summary: https://www.nejm.org/doi/full/10.1056/NEJMoa2601005
Images in Clinical Medicine: Minocycline-Induced Hyperpigmentation https://www.nejm.org/doi/full/10.1056/NEJMicm2513782
#Dermatology #InfectiousDisease
Session 1 features our executive sponsors:
Dr. Meera Kataria Atkins | @lyricclarity
Ashok Chennuru | @ElevanceHealth
Dr. Andrew M. Ibrahim | @viz_ai
Dr. @zakkohane | @NEJM_AI
Dr. David C. Rhew | @Microsoft
Sign up and view the full speaker lineup: https://nejm.ai/4lOe1iO
Original Article: CRISPR-Cas12a Gene Editing of HBG1 and HBG2 Promoters to Treat β-Thalassemia (EdiThal study) https://www.nejm.org/doi/full/10.1056/NEJMoa2501277
Editorial: More Options for Gene Editing in Hemoglobinopathies https://www.nejm.org/doi/full/10.1056/NEJMe2602194
Further reading:
📄 Original Article: Base Editing of HBG1 and HBG2 Promoters for Sickle Cell Disease (BEACON study) https://www.nejm.org/doi/full/10.1056/NEJMoa2504835
📄 Original Article: CRISPR-Cas12a Gene Editing of HBG1 and HBG2 Promoters to Treat Sickle Cell Disease (RUBY study) https://www.nejm.org/doi/full/10.1056/NEJMoa2415550
Perspective essay by @MichaelRUlrich, JD, MPH: Therapy’s Conversion — 𝘊𝘩𝘪𝘭𝘦𝘴 𝘷. 𝘚𝘢𝘭𝘢𝘻𝘢𝘳’s Threat to Mental Health Treatment and Standards of Care https://www.nejm.org/doi/full/10.1056/NEJMp2516723
[Note: On March 30, the Court held that Colorado’s law was a content-based viewpoint restriction of speech that requires lower courts to apply the most stringent form of judicial review.]
#HealthPolicy #HealthLaw
What were the big cardiology headlines to come out of #ACC26? Dr. André Sofair talks with cardiologists Dr. Karol Watson (@kewatson) and Dr. David Cohen (@djc795) about their biggest takeaways. Full highlights: https://jwat.ch/3OhIjy3