Impf_Info – Following Feed 478 Posts (gefiltert)

The authors of a new Perspective argue that a Tennessee bill focused on directed blood donation exemplifies a pattern of efforts to legislate medical practice in ways that override scientific consensus while invoking the language of autonomy. Learn more: https://www.nejm.org/doi/full/10.1056/NEJMp2602587

In the BEACON study involving persons with sickle cell disease, adenine base editing was used to target the promoters of HBG1 and HBG2 in autologous hematopoietic stem cells to increase fetal hemoglobin expression. Full study results: https://www.nejm.org/doi/full/10.1056/NEJMoa2504835 Editorial: More Options for Gene Editing in Hemoglobinopathies https://www.nejm.org/doi/full/10.1056/NEJMe2602194 Further reading: 📄 Original Article: CRISPR-Cas12a Gene Editing of HBG1 and HBG2 Promoters to Treat Sickle Cell Disease (RUBY study) https://www.nejm.org/doi/full/10.1056/NEJMoa2415550 📄 Original Article: CRISPR-Cas12a Gene Editing of HBG1 and HBG2 Promoters to Treat β-Thalassemia (EdiThal study) https://www.nejm.org/doi/full/10.1056/NEJMoa2501277

Perspective essay by W. Michael Brode, MD: Number Needed to Treat https://www.nejm.org/doi/full/10.1056/NEJMp2511419 #MedicalStatistics #MedicalPractice

Sign up now for the next @NEJM_AI free virtual event: Value Alignment & Incentive Divergence in Clinical AI As AI becomes embedded in clinical decision-making, different models prioritize decisions in different ways. What does that mean for patients, clinicians, and health systems? Learn more and sign up: https://events.nejm.org/events/803?promo=OAFYX422&query=nejm-social&utm_source=x&utm_medium=social&utm_campaign=2026_aievent422

Correspondence: Probable Japanese Encephalitis Virus Transmission through Organ Transplantation https://www.nejm.org/doi/full/10.1056/NEJMc2514269 #IDTwitter

In a report from Singapore, the release of wolbachia-infected, irradiated male 𝘈𝘦𝘥𝘦𝘴 𝘢𝘦𝘨𝘺𝘱𝘵𝘪 mosquitoes resulted in a reduction in the vector population and in the risk of dengue infection. Full trial results and Research Summary: https://www.nejm.org/doi/full/10.1056/NEJMoa2503304

Case Record of the Massachusetts General Hospital (@MassGeneralNews): A 12-Year-Old Girl with Altered Mental Status and Hypoglycemia https://www.nejm.org/doi/full/10.1056/NEJMcpc2517859 #Pediatrics

Images in Clinical Medicine: Walled-Off Pancreatic Necrosis https://www.nejm.org/doi/full/10.1056/NEJMicm2515752 #Surgery #Gastroenterology

A new review by Anders Juul, MD, DMSc, PhD, summarizes the current understanding of minipuberty and describes its potential clinical implications. Read the full review: https://www.nejm.org/doi/full/10.1056/NEJMra2305989

Perspective by Genevieve P. Kanter, PhD (@ProfGenKanter): Conflicts of Interest in Advisory Committees — Facts, Fallacies, and the Limits of Reform https://www.nejm.org/doi/full/10.1056/NEJMp2514012 #HealthPolicy #MedicalEthics

R to @ACCinTouch: IVUS-Guided versus Angiography-Guided PCI in Unprotected Left Main Coronary Disease (OPTIMAL trial) https://www.nejm.org/doi/full/10.1056/NEJMoa2600440

R to @ACCinTouch: Intravascular Ultrasound–Guided or Angiography-Guided Complex High-Risk PCI (IVUS-CHIP trial) https://www.nejm.org/doi/full/10.1056/NEJMoa2601521

R to @ACCinTouch: Sirolimus-Coated Balloon Angioplasty for Infrainguinal Artery Disease (phase 3 SirPAD trial) https://www.nejm.org/doi/full/10.1056/NEJMoa2600360

R to @ACCinTouch: Discontinuation of Beta-Blocker Therapy after Myocardial Infarction (SMART-DECISION trial) https://www.nejm.org/doi/full/10.1056/NEJMoa2601005

R to @ACCinTouch: Mavacamten in Adolescents with Obstructive Hypertrophic Cardiomyopathy (phase 3 SCOUT-HCM trial) https://www.nejm.org/doi/full/10.1056/NEJMoa2601103

R to @ACCinTouch: Angiography-Based Physiology to Guide Coronary Revascularization (FAST III trial) https://www.nejm.org/doi/full/10.1056/NEJMoa2601841

R to @ACCinTouch: Angiography-Derived Fractional Flow Reserve to Guide PCI (ALL-RISE trial) https://www.nejm.org/doi/full/10.1056/NEJMoa2600949

R to @ACCinTouch: Left Ventricular Unloading in High-Risk Percutaneous Coronary Intervention (CHIP-BCIS3 trial) https://www.nejm.org/doi/full/10.1056/NEJMoa2515704

R to @ACCinTouch: Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease (Ez-PAVE trial) https://www.nejm.org/doi/full/10.1056/NEJMoa2600283

R to @ACCinTouch: Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism (HI-PEITHO trial) https://www.nejm.org/doi/full/10.1056/NEJMoa2516567

R to @ACCinTouch: Left Atrial Appendage Closure or Anticoagulation for Atrial Fibrillation (CHAMPION-AF) https://www.nejm.org/doi/full/10.1056/NEJMoa2517213

#ACC26 Round Up: Eleven Original Articles were simultaneously published in NEJM and presented at this year’s American College of Cardiology Scientific Sessions in New Orleans. View the full thread for all @ACCinTouch articles and bookmark this post for future reference.

Images in Clinical Medicine: Facial Synkinesis https://www.nejm.org/doi/full/10.1056/NEJMicm2506222 #Neurology

For patients with atherosclerotic cardiovascular disease, guidelines recommend intensive lowering of LDL cholesterol, but evidence supporting a stricter LDL target remains limited. Research findings from the Ez-PAVE trial are summarized in a new Quick Take video. https://www.nejm.org/doi/full/10.1056/NEJMdo008431

Medicine and Society by the Consortium of the Center to End Corporate Harm, University of California, San Francisco (@UCSF_PRHE): Corporate Vectors of Chronic Disease — Using Internal Industry Documents to Craft Counterstrategies https://www.nejm.org/doi/full/10.1056/NEJMms2507028

Volume 3, No. 4 of NEJM AI is now available! Here is a preview of the latest content: 𝗘𝗱𝗶𝘁𝗼𝗿𝗶𝗮𝗹 Health Systems Govern Only the Tip of the AI Iceberg https://nejm.ai/4sQFxz6

Original Article: IVUS-Guided versus Angiography-Guided PCI in Unprotected Left Main Coronary Disease (OPTIMAL trial) https://www.nejm.org/doi/full/10.1056/NEJMoa2600440 Editorial: Seeing the Left Main Coronary Artery Clearly — Is IVUS Always Necessary? https://www.nejm.org/doi/full/10.1056/NEJMe2602959 #ACC26 | @ACCinTouch

Original Article: Intravascular Ultrasound–Guided or Angiography-Guided Complex High-Risk PCI (IVUS-CHIP trial) https://www.nejm.org/doi/full/10.1056/NEJMoa2601521 Editorial: IVUS — A Zigzag Path to Success https://www.nejm.org/doi/full/10.1056/NEJMe2603397 #ACC26 | @ACCinTouch

Correspondence: Treatment-free Remission in Chronic Myeloid Leukemia in Low- and Middle-Income Countries https://www.nejm.org/doi/full/10.1056/NEJMc2518028 #Hematology

Early surgery in asymptomatic patients with very severe aortic stenosis led to a lower risk of a composite of operative mortality or death from cardiovascular causes at 10 years than conservative care. Full RECOVERY trial results and Research Summary: https://www.nejm.org/doi/full/10.1056/NEJMoa2511920

Original Article: Discontinuation of Beta-Blocker Therapy after Myocardial Infarction (SMART-DECISION trial) https://www.nejm.org/doi/full/10.1056/NEJMoa2601005 #ACC26 | @ACCinTouch

In a study by Gori and colleagues, gene editing with a prime editor was used to treat two persons with chronic granulomatous disease caused by a small deletion in the gene NCF1. Full study results: https://www.nejm.org/doi/full/10.1056/NEJMoa2509807 Editorial: Genetic Medicine — Primed and Ready https://www.nejm.org/doi/full/10.1056/NEJMe2601003 #Hematology

Our latest video in our partnership with @DGlaucomflecken summarizes the CORALreef Lipids trial, which assessed the efficacy of the oral PCSK9 inhibitor enlicitide in reducing LDL cholesterol levels over a 52-week period. Read the full study for free: https://nej.md/DrG37 #cardiology

Perspective by Jaime S. King, JD, PhD, Katherine L. Gudiksen, PhD, and Anna D. Sinaiko, PhD, MPP: Playing Favorites — State Protection of Academic Medical Centers from Antitrust Oversight https://www.nejm.org/doi/full/10.1056/NEJMp2514565 #HealthPolicy #HealthLaw

Release of sterile male 𝘈𝘦𝘥𝘦𝘴 𝘢𝘦𝘨𝘺𝘱𝘵𝘪 mosquitoes infected with the 𝘸AlbB strain of 𝘞𝘰𝘭𝘣𝘢𝘤𝘩𝘪𝘢 𝘱𝘪𝘱𝘪𝘦𝘯𝘵𝘪𝘴 bacteria is a method for control of dengue virus infection. Research findings are summarized in a new Quick Take video. https://www.nejm.org/do/10.1056/NEJMdo008317/full/

In the phase 3 ATOMIC trial in resected stage III mismatch repair–deficient colon cancer, adding atezolizumab to modified FOLFOX6 improved 3-year disease-free survival, with a higher incidence of grade 3 or 4 toxic effects, mainly fatigue.  Full trial results and Research Summary: https://www.nejm.org/doi/full/10.1056/NEJMoa2507874

Images in Clinical Medicine: Eczema Herpeticum https://www.nejm.org/doi/full/10.1056/NEJMicm2516038 #Dermatology #InfectiousDisease

A critical issue is coming into focus as AI becomes further embedded in clinical decision-making: different AI models consistently prioritize clinical decisions in unique ways — and those differences impact patients, clinicians, and organizations alike. https://nejm.ai/4lOe1iO

Perspective by Douglas J. Opel, MD, MPH, and Sean T. O’Leary, MD, MPH: Communicating about Vaccines in a Politically Contentious Climate https://www.nejm.org/doi/full/10.1056/NEJMp2600539 #HealthPolicy #MedicalEthics

The Troubling Rise of Medical Credit Cards @NEJMClinician Editor-in-Chief Raja-Elie Abdulnour, MD (@BageLeMage), outlines some of the concerns about medical credit cards and how clinicians can guide patients. Christopher W. Goodman, MD, highlights the key points from a recent Perspective published in NEJM: https://jwat.ch/4m1xyN0 Visit http://clinician.nejm.org to see What Matters Most This Week, including: 🫀 Do Inpatients with Acute Heart Failure Need a Low-Salt Diet? 🧠 Screening for Adherence to Antiseizure Medication in Children with Epilepsy 🚫 Cannabis Use and PTSD: Abstinence Seems Best 💊 Individualized mRNA Vaccine against Breast Cancer