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The day after the historic blizzard that shattered all previous Rhode Island state records with >37 inches of snow.

*Providence, RI Update* 37.9" of snow. Top all-time snowstorm and the 24-hour state record for snowfall was possibly broken today This is more snow than the ENTIRETY of 6 of the past 7 winters. The only one with more was 2022, and it was barely more than this (43.5"). #wbz

The numbers are worse and not reported here for NCI unfortunately. NIH research grant funding rates plummeted in 2025 Agency acknowledges young investigators are losing out as result of multiyear funding policy imposed by White House https://www.science.org/content/article/nih-research-grant-success-rates-plummeted-2025

The NHS-Galleri trial results came out last Friday. 142,000 participants. 3 years. The most ambitious cancer screening trial ever run. The headlines: primary endpoint missed. That's a fact, and it matters. But I believe the headlines are missing the deeper story in these data – one that matters enormously to patients and to the future of cancer screening. Here's what the NHS-Galleri Test study showed: ✅ Stage IV cancer diagnoses – metastatic, typically incurable disease – declined substantially in the screened group, with >20% reductions across the 12 deadliest cancer types ✅ More cancers were found at Stage I & II, when treatment can be curative, in cancers that are typically diagnosed late (pancreatic, ovarian, liver, lung) ✅ 4x higher overall cancer detection rate when Galleri was added to standard screening (i.e., colonoscopy & mammography) ✅ Fewer cancers detected through emergency presentation – the worst possible way to learn you have cancer, and the most lethal and most costly ✅ No serious safety concerns. Test performance consistent with prior studies (with very high 99.5% specificity and very low false positive rate) So why did the 'primary endpoint' miss? See article for more detail & perspective on the study design, and the 'Stage Migration paradox' that masks enormous progress and clinical impact for patients.

High snow accumulation in Rhode Island and it’s still coming down.

JUST IN: Providence, Rhode Island has officially measured their most extreme snowstorm in recorded history, with 32.8 in of snowfall and climbing. The previous record was 28.6 in, set during the Blizzard of 1978. Historic radar loop.

**ALL-TIME RECORD** Providence is up to 32.8" and counting, surpassing the Blizzard of '78. Records date to 1904. Still snowing. #wbz

BREAKING: PROVIDENCE HAS JUST BROKEN THE ALL TIME SNOWFALL RECORD WITH A STAGGERING 32.8" BEING REPORTED AT 1PM AT T.F. GREEN AIRPORT❄️ @NBC10

Second 2026 blizzard in Rhode Island.

The Nor'easter has gone through incredible bombogenesis, which has dropped nearly 40 mb over the past 24 hours and is currently at 972 mb at the center where you can see an eye has developed. This is the kind of Nor'easter you read about in textbooks. Remarkable.

Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC https://www.nature.com/articles/s41586-025-10004-2

Nature Medicine starts an investigation into inconsistencies in a study that found it was better to have immunotherapy in the morning. https://trib.al/6nK52aA

Brown University Health researchers identify new target for glioblastoma treatment https://pbn.com/brown-university-health-researchers-identify-new-target-for-glioblastoma-treatment/

Just stick with informed consent and remember that the COVID mRNA vaccines are the first time modified mRNA was used in humans. There were unexpected findings and nuances with regard to broad mandates for the population. There are always reasonable alternative options that respect individual autonomy. Is 'shared decision-making' being hijacked by U.S. health officials to sow doubt about vaccines? https://www.statnews.com/2026/01/20/shared-decision-making-vaccine-guidance-twists-meaning-of-term/

It is past time for the academic community at-large to acknowledge that post-publication review has become weaponized and is being used as a tool to selectively target physicians and scientists around the world in a manner that damages reputations and destroys careers. The activity appears to target suppression of scientific findings or concerns that go against some mainstream narratives or ideologies with ultimate silencing and prevention of the scientific process. A recent payout of $15 million further incentivizes the behavior and further undermines public trust in science or scientists. There are many many issues with what is currently happening in an unregulated manner and this needs to be addressed by the medical profession, universities, publishers as well as the appropriate government agencies.

Shocking study linking covid jabs and cancer 'censored' by mysterious cyberattack https://www.dailymail.co.uk/sciencetech/article-15440249/cancer-Covid-vaccination-journal-cyberattack.html

The coordinated attacks being conducted against high-integrity science that happens to contradict Big Pharma’s narrative represent a serious threat to scientific research and the advancement of knowledge. The most recent examples involving Drs. Hazan and El-Deiry seem particularly egregious.   What are those carrying out these attacks trying to hide?

🔱 Science, research, and academia exist to improve the lives and well-being of the global community 🔱 Every topic that affects human health and society deserves to be researched deeply and thoroughly — even when it challenges the status quo. No researcher or scientist should ever face harassment, intimidation, or censorship for asking legitimate scientific questions. Today, we encourage everyone to read the recent public message shared by Kazuhiro Haraguchi @kharaguchi — Member of the House of Representatives in Japan and Former Minister of Internal Affairs and Communications — addressed to @TuftsMedSchool Professor Charlotte Kuperwasser (@KUPERWASSERLAB) and @BrownUniversity Professor Wafik El-Deiry (@weldeiry). His reflections on his experience, his diagnosis, and the scientific questions raised are profound and deserve careful attention. 🚨 In June 2025, we published a major exposé for the first time: “The PubPeer Network Mob — Inside the Mechanism of a Coordinated Academic Smear Operation.” 🔗 https://x.com/SciGuardians/status/1934331058272772585 In that investigation, we documented how a criminal mob network — operating by exploiting the compromised PubPeer platform, widely referred to within the academic community as “PubSmear” — takes advantage of the vacuum in research integrity, using that banner to orchestrate harassment, smearing, and defamation campaigns against targeted researchers and scientists. This network has been relying on its signature tactic: ⚠️ partial truth — concealing its primary malicious agenda behind selectively framed fragments of genuine research-integrity concerns. 📌 One clear example we highlighted: ➡️ how one of the world’s most celebrated oncologists, Professor Wafik El-Deiry of Brown University, became a target — not because of misconduct, but because he began asking important, uncomfortable questions in areas related to vaccine research, with potential implications for the pharmaceutical industry and its share-market values. 🔱 What we said then remains true today: • Difficult scientific questions must be researched — not silenced. • Debate strengthens science — intimidation destroys it. • No scientist should face reputational attacks simply for doing honest work. We, at @SciGuardians, will continue dismantling these criminal structures, exposing their malicious tactics, and defending those who are targeted for pursuing truth. 🔱 ScienceGuardians™ Accountability. Integrity. Empowerment.

My question is why are there more tertiary lymphoid structures and T-cell infiltrates in the responders? My other question from what has been observed previously is what is different between liver metastases that don’t respond and lung metastases that do respond to Bot/Bal in MSS mCRC. The answer can’t just be because there are more immune infiltrates. The question is why or what is suppressing this in the liver that may be possible to overcome through additional interventions that could boost responses. @oncodaily @justin_ste74939

Rhode Island House of Representatives Speaker Joseph Shekarchi was honored to receive 2025 Legorreta Cancer Center Public Service Award. @RIHouseofReps @JoeShekarchi @BrownUniversity @BrownMedicine @BrownUCancer @BrownUnivHealth @carenewengland @SenJackReed @SenWhitehouse @RepGabeAmo @GovDanMcKee @MiaForRep @The_Ryan_Strik

It was a personal triumph to be at this STOP Cancer Summit for Novel Therapeutics in Oncology & Precision Medicine in Cancer meeting in Las Vegas and deliver my first talk since my 8-hour open heart surgery at the end of July. It went very well.

ACIP Presentation on 9-19-2025: Safety Uncertainties of mRNA COVID Vaccines Kuperwasser/El-Deiry. https://youtu.be/F7tD7dlb40U

🔥🎙️HOT OFF THE PRESS 📰 It was an enormous honor to interview rockstar researcher/ oncologist Dr. Wafik El-Deiry @weldeiry, whose breakthroughs have transformed our understanding of cancer. His discovery of the p53 gene, known as the “guardian of the genome,” plays a crucial role in preventing cancer. This foundational work has shaped diagnostics, treatments, and targeted therapies. As Associate Dean at Brown University, Dir. of the Legorreta Cancer Center, and NCI Director nominee, Dr. El-Deiry holds an MD/PhD and has published over 300 papers. His bombshell research potentially linking the spike protein to cancer has sparked widespread debate—and for good reason. 🤯 💣 We discuss that and much more! Key Topics: 🚩The alarming rise of cancers in young adults 🚩Early warning signs of colon cancer & screening tips 🚩Is COVID a cancer-causing virus? 🚩The urgent need for transparent data on vaccine safety and long-term effects 🚩Potential links between mRNA vaccines and lymphomas/sarcomas 🚩The future of mRNA therapy for cancer 🚩Can anti-parasitics treat cancer? 🚩The harassment scientists face for publishing inconvenient data 🚩His vision for cancer research if he becomes the next NCI Director This is one of the most nuanced conversations on cancer, science, and transparency you’ll hear. Whether you're a patient, physician, or researcher, don’t miss it! Please share & drop a comment. We wanna know what’s on your mind. 🎧 Find “The Dana Parish Podcast” across all podcast platforms & YouTube! Huge thanks to my editor, Conrad deVroeg. 📺 PLEASE support my hard work by subscribing to my YT Channel and Substack, for more exclusive, uncensored conversations. Links in bio or below ⬇️ Thanks so much for watching! 🩷 🙏

Simply outstanding news for patients with cancer & research Knight Cancer Institute receives record-setting $2B gift from the Knights—and self-governance within OHSU Brian Druker returns to executive role as president of the new Knight Cancer Group https://cancerletter.com/conversation-with-the-cancer-letter/20250814_1/

Proud of our @BrownPathology department for 16% of inventions and #eldeirylab for 8% of inventions at @BrownUniversity over a 3 year period 2023-2025. @BrownMedicine @BrownUCancer #LegorretaCancerCenter @ShiOnaCo @rwsobol @SeanLawler20 @BrownUnivHealth

And our preclinical work of combination therapy awaits translation👇 Synergistic combination therapy with ONC201 or ONC206, and enzalutamide or darolutamide in preclinical studies of castration-resistant prostate cancer https://pmc.ncbi.nlm.nih.gov/articles/PMC11711516/

My lab discovered a treatment for prostate cancer that helped some men over 90 to shrink bone metastases, reduce pain w/o side effects. Safety & enhanced immunostimulatory activity of ONC201 in advanced solid tumors with weekly oral administration https://jitc.bmj.com/content/7/1/136

If you suffered an injustice you should fight for truth and justice, not target others. I have no idea who you are or where you are. You post in another language on X and so you maybe anywhere in the world. Imposing censorship on scientific publishing is not the solution to bullshit. Censorship in science is a real problem and I fully agree with the current @NIHDirector_Jay stance on consideration of alternative views and freedom of speech. Just think for a minute why anyone would publish bullshit? Do you have zero respect for scientists? Do you judge without rigor and just jump to conclusions? As I said I have been targeted by criminal activity with what I believe is malicious political motivations with unknown conflicts of interest. My research has never had any fraud or misconduct. Our results have stood the test of time for decades. We have not published any bullshit. And in any event, most science is iterative and evolves as models of scientific truth evolve. Very little is truly seminal and I know what that is as well.

More changes at OHSU after Dr. Druker stepped down as CEO in December👇 Director of Knight Cancer Institute Exits After Just One Year https://www.wweek.com/news/2025/04/09/director-of-knight-cancer-institute-exits-after-just-one-year/

Imatinib and the dawn of precision cancer therapy Brian J. Druker describes how his research on imatinib validated protein kinases as therapeutic targets for cancer and led to a life-saving treatment for leukemia. https://www.nature.com/articles/s41591-024-03436-2

One of the good reasons to pursue leadership roles is to make sure the environment we work in is supportive of the mission that Dr. Druker upholds. In the best environments he would not have had to take the decision he chose. He represents hope for so many and is a role model for many as well.

Dr. Druker’s resignation is (an extremely sad and) an extremely powerful statement about the current state of affairs in science, medicine, and academia. He deserves much respect and a voice to address a badly broken system with much injustice. @HemOncToday @ASCOPost @theNASEM @DrJBhattacharya @NIHDirector @HHSGov @theNCI @NCIDirector @AACR @AACR_CEO @TheCancerLetter @oncodaily @OHSUKnight

OHSU Knight Cancer Institute CEO Brian Druker resigns amid tumultuous year https://www.kgw.com/article/money/business/brian-druker-resigns-ohsu-knight-cancer-institute-ceo/283-1438d2fe-4c8f-461e-a6aa-e1855c781ddc

Dr. Brian Druker, head of OHSU’s Knight Cancer Institute, steps down: ‘We have ... forgotten our mission’ https://www.oregonlive.com/health/2024/12/head-of-ohsus-knight-cancer-institute-steps-down-we-have-forgotten-our-mission.html

Beckerle releases statement after return to leadership of Huntsman Cancer Institute http://kutv.com/news/local/beckerle-releases-statement-after-return-to-leadership-of-huntsman-cancer-institute

Former CEO of Huntsman Cancer Institute, Dr. Beckerle, reinstated http://via.fox13now.com/1DBGo via @fox13