SZwanglos – Following Feed

Discussed Breast Cancer Stem-Like Cells at MIT Seminar - Wafik S. El-Deiry @weldeiry @BrownUniversity @SenduraiMani https://oncodaily.com/voices/wafik-s-el-deiry-466307 #OncoDaily #Oncology #Cancer #Health #Medicine #MedX #MedTwitter

Homologous recombination deficiency and hemizygosity drive resistance in breast cancer https://www.nature.com/articles/s41586-026-10197-0

Meningeal blood vessel blockage enhances anti-glioblastoma immunity https://www.cell.com/cell/abstract/S0092-8674(25)01494-1

It is clear someone like @realrickpazdur is needed at the @US_FDA @RobertKennedyJr @HHSGov 5 lessons from Vinay Prasad's turbulent tenure at the FDA By @matthewherper https://www.statnews.com/2026/03/08/vinay-prasad-fda-lessons-from-tenure/

Immunobiology and Immunotherapies for RAS Malignancies: Former AACR Presidents Philip Greenberg and Elizabeth Jaffee joined Ron DePinho, Lauren Stopfer, and Esra A. Akbay to address this topic in a plenary session at #AACRras26. @RonDePinho @lstops @EsraAkbay_

Worth watching presentation by Dr. Tom Waldmann at @NIH @theNCI from 2017 to appreciate promise, complexity and potential downside of IL-15 @DrPatrick @DrMakaryFDA @NIHDirector_Jay @DrTonyLetai @DrKarenKnudsen @ChrisCuomo @PeterPitts

Poster presenters shared their work with attendees Saturday evening during the AACR Special Conference on RAS Oncogenesis and Therapeutics. The meeting concludes on Sunday in Los Angeles. #AACRras26

Very excited about bringing VEGF bispecifics into the brain mets space. This builds off @nlinmd data with Carbo and Bev showing CNS ORR of > 60%. Pseudo response is real necessitating CNS-PFS as a complementary end point.

Cortical CL1: Real human 800,000+ neurons on chip already beating DQN/PPO baselines in complex tasks with minimal training time.🤯 Adaptive learning is like a real brain. Outperforms SOTA RL (DQN, PPO) after 5 min gameplay-style training

David Hong, Ferdinandos Skoulidis, Eileen O’Reilly, Jonathan Pachter, and Andrea Lopez-Arroyo discussed "RAS Clinical Trials and New Therapies" in a plenary session at the AACR Special Conference on RAS Oncogenesis and Therapeutics. #AACRras26 @FSkoulidis @EileenMOReilly

#tmylswotmyls #eldeirylab

Breakthrough Discovery Could Make Pancreatic Cancer Respond to Chemo Again https://scitechdaily.com/breakthrough-discovery-could-make-pancreatic-cancer-respond-to-chemo-again/

I enjoyed asking Bob Weinberg at @MIT a question after his wonderful seminar organized by @SenduraiMani at @BrownUniversity yesterday regarding the potential for breast cancer stem-like cells with hybrid EMT characteristics to interconvert among clinical breast cancer subtypes and whether this might be targeted in therapeutic design to decrease tumor aggressiveness.

NIH Video Cast addressing IL-15 they all know start at 5:90 https://youtu.be/h7qixNkRAco?si=NSaUwS3JcN7k31ET

Pleased to see most recent world, national and university rankings in molecular biology according to http://research.com @BrownPathology @BrownUniversity @BrownMedicine @BrownUCancer #LegorretaCancerCenter #eldeirylab

Day 3 of the AACR Special Conference on RAS Oncogenesis and Therapeutics will feature a plenary session on RAS clinical trials as well as a keynote address by Mallika Singh. #AACRras26

Yes, it's real. Cortical Labs (Australia) cultured ~200,000 living human neurons on a chip with electrode arrays. They mapped the cells' electrical signals to control Doom's movement and shooting. The neurons adapted in about a week, learning basic navigation/shooting like total beginners. It's a big leap from their 2022 Pong demo toward biological computing. Wild tech!

🚨: A petri dish of human brain cells just learned to play DOOM

Controversial question from John Heymach at #NYLCF26: How can we start screening all for lung ca? ▶️Need spot check tools, that don't require serial CTs ▶️Need to screen all patients at risk, regardless of smoking hx. Led by @fred_hirsch @EddieSantosMD @caitlinanichols @maraantonoff

Now online: Discovery of BBO-11818, a Potent and Selective Noncovalent Inhibitor of (ON) and (OFF) KRAS with Activity against Multiple Oncogenic Mutants https://doi.org/10.1158/2159-8290.CD-25-1280

Good read👇 “What’s so religious about opposing vaccines?” https://www.statnews.com/2026/03/06/religious-exemption-vaccines-amish-vaccination-hesitancy-examined/

NIH reneges on recognizing union for early-career researchers The biomedical research agency says trainees in its labs are not “employees” https://www.science.org/content/article/nih-reneges-recognizing-union-early-career-researchers

Important discussions at today’s #LegorretaCancerCenter Leadership Advisory Group Meeting about upcoming events including Inaugural Caris POA national investigator meeting in the Spring of 2026 at @BrownMedicine, updates from today’s @AACI_Cancer Cancer Center Director Town Hall meeting on DoD/CDMRP funding, the FAIR Model, hiring at @NIH, trends in grant award release by @NIH, 2026 Translational Symposium and TRDG Retreat, COE/CAB, Cape Verde Community presentation by Dr. Safran and outcome measures, recent visit by Paul Campbell @AmericanCancer, ACS-IRG grant renewal plans, grant opportunities, planning for next EAB meeting, and ongoing recruitments such as Surgical Oncology Chief, Pediatric Hem-Onc Chief and Section Chief of Breast Surgery @BrownUnivHealth. @BrownMedicine @Brown_SPH @carenewengland @brownengin @Brownsurgical @ShiOnaCo @LiangChengMD @rwsobol @SenduraiMani @bcarneiro7 @CaraMath @LauraStroudPhD @SheRiseRogersMD @DawsonStemCell @SeanLawler20 @DrSGraff

Great presentation today at the #LegorretaCancerCenter Cancer Biology Program meeting by @KMDaileyPhD, Assistant Professor, Dept. of Biomedical & Pharmaceutical Sciences, URI Faculty Scholar, Rhode Island IDeA Network of Biomedical Research Excellence (RI-INBRE) on “Changing the Paradigm: Developing Clostridium novyi-NT as an Intravenous Pancreatic Cancer Therapeutic.” @rwsobol

At least @VPrasadMDMPH will soon be free again to share his candid views — now with added insight from his time at the FDA. He’s not done, and his critics will still have to contend with his thinking.

In his own words, Dr. Robert Weinberg @MIT explains the iconic EMT figure during his seminar @BrownUniversity this morning. This was inaugural presentation in Hallmarks of Cancer Series organized by @SenduraiMani #LegorretaCancerCenter

This morning we were so fortunate to have a seminar presentation by Professor Robert Weinberg from @MIT as the inaugural talk in a new series on the Hallmarks of Cancer organized by Dr. @SenduraiMani at @BrownUniversity. #LegorretaCancerCenter @BrownMedicine Bob Weinberg taught about metastatic cancer, the role of EMT, stem cells, plasticity and tumor dormancy. He inspired, gave advice to younger scientists, and answered many questions. https://www.linkedin.com/posts/wafike_legorretacancercenter-activity-7435845735943913473-duFm

Vascular STING activation facilitates NK cell anti-tumor immunity in small cell lung cancer https://www.cell.com/cancer-cell/abstract/S1535-6108(26)00106-6

The FDA's head of vaccines and biologic medicines will leave the agency at the end of April, a spokesperson confirmed to CNN. https://cnn.it/4swYxC1

Breaking News: Dr. Vinay Prasad, a polarizing figure at the FDA who oversaw vaccines, is leaving the agency. As the chief science and medical officer, he made several controversial decisions, such as overruling career scientists on some vaccine approvals. https://nyti.ms/4bfAXCP

Vinay Prasad, key Makary ally and a focus of controversy at the FDA, is leaving the agency https://www.statnews.com/2026/03/06/fda-vinay-prasad-controversial-cber-director-leaving/

In @CD_AACR coinciding with #AACRras26: Discovery of BBO-11818, a Potent and Selective Noncovalent Inhibitor of (ON) and (OFF) KRAS with Activity against Multiple Oncogenic Mutants https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-25-1280/774990/Discovery-of-BBO-11818-a-Potent-and-Selective

FDA's Controversial Vaccines Chief Will Leave the Agency Dr. Vinay Prasad will depart in April, after a year leading the division that approves vaccines and biotech drugs https://www.wsj.com/health/healthcare/fdas-controversial-vaccines-chief-will-leave-the-agency-7fe59aa3

Congratulations to our @ppisters on receiving the Charles M. Balch, M.D., Distinguished Service Award at #SSO26. This prestigious award highlights his outstanding commitment to and leadership within the field of surgical oncology. Read more: http://spr.ly/6014hhhjI #EndCancer

“The TP53 gene contains a diversity box that makes it more than a tumor suppressor” Find this informative and well-constructed review here: https://rdcu.be/e7boq

5th Anniversary Thematic Collection: Manipulating DNA Repair and the DNA Damage Response to Improve Cancer Therapy https://academic.oup.com/narcancer/pages/manipulating-dna-repair

A glucocorticoid–FAS axis controls immune evasion during metastatic seeding https://www.nature.com/articles/s41586-026-10222-2

Homologous recombination deficiency and hemizygosity drive resistance in breast cancer https://www.nature.com/articles/s41586-026-10197-0

As a private citizen I appreciate @keithhoffmann, a native Rhode Islander, as a superb candidate for next Attorney General of Rhode Island. He has deep expertise and a strong persona to effectively serve Rhode Islanders and to address many important issues including in healthcare, the environment, and public safety among others. He will make sure the government serves the people. Current RI AG @AGNeronha who knows Keith very well through their work together gave him a very strong endorsement.

Love this.