Genetic differences may help explain why some patients experience greater weight loss or more adverse effects on #GLP1 receptor agonists such as #semaglutide or #tirzepatide, according to a new genome-wide association study using consumer genetic data.
JAMA Medical News Associate Managing Editor Kate Schweitzer and staff writer Samantha Anderer discuss how pharmacogenetics could inform future clinical approaches to GLP-1 prescribing, possible clinical implications, and expert perspectives on the path toward precision #obesity care.
🎧 Listen now: https://ja.ma/4tIiuXp
Among patients undergoing isolated coronary artery bypass graft surgery, relaxed potassium supplementation (threshold <3.6 mEq/L) was noninferior to tight supplementation (threshold <4.5 mEq/L) in preventing arrhythmias short-term and demonstrated comparable 6-month rates of mortality, atrial tachyarrhythmia, stroke, and quality of life.
These findings support flexibility in potassium supplementation protocols after #CABG without affecting medium-term clinical or patient-reported outcomes.
https://ja.ma/4tapZp4
#HeartFailure (HF) affects more than 64 million individuals worldwide, and acute HF is associated with 1-year mortality rates of 23.6% in North America and Europe.
Cardiac resynchronization therapy restores synchronous ventricular activation in patients with HF, reduced LVEF, and left bundle-branch block, or in those requiring chronic ventricular pacing, and may improve LV function, decrease HF hospitalizations, and reduce mortality.
🔗 Learn more in this JAMA Review: https://ja.ma/42dxccX
Med News: In March, more than 50 US medical schools committed to boosting nutrition training under a new HHS initiative. Experts welcome the push but say competencies should be evidence-based and realistic.
https://ja.ma/4usNYB4
📊 JAMA Clinical Guidelines Synopsis: The 2025 ACC/AHA guideline recommends home and office blood pressure monitoring to confirm diagnosis and titrate medications, with a target blood pressure of <130/80 mm Hg for most adults.
https://ja.ma/4tapzPw
📌 Editor’s Choice from this week's issue of JAMA:
➡️ Review on Obesity and Cancer,
➡️ Preventing Pregnancy-Related CVD Burden,
➡️ Tumor Debulking Plus Chemotherapy in Multiorgan mCRC, and more.
https://ja.ma/4vJdqDI
#Microplastics are plastic fragments smaller than 5 mm that results from breakdown of plastic litter.
This JAMA Patient Page describes microplastics and the potential health effects of human exposure to microplastics.
https://ja.ma/3QqSocM
💬 Editorial: The ORCHESTRA trial demonstrated that surgical or ablative debulking strategies in multiorgan metastatic #ColorectalCancer do not improve overall or progression-free survival when added to #chemotherapy.
https://ja.ma/4sN4fQ0
Among adults with multiorgan metastatic #ColorectalCancer, adding local debulking to chemotherapy did not improve survival and increased serious adverse events.
https://ja.ma/3QjR3EI
📊 JAMA Guide to Statistics and Methods: The Hochberg procedure is a multiplicity correction used in clinical trials to control the familywise error rate when comparing multiple end points.
Learn more: https://ja.ma/4cUGFvM
#Obesity is associated with higher risk for 12 #cancer types and accounts for approximately 10% of annual new cancer cases in the US.
📄 This Review summarizes the primary biological pathways connecting obesity and cancer development.
https://ja.ma/3QmlV7C
💬 Perspective: A National Academies report identifies missed opportunities to prevent pregnancy-related #CardiovascularDisease, highlighting gaps in risk identification and care continuity before, during, and after pregnancy.
https://ja.ma/4cLyctQ
State-level decriminalization of #Psilocybin in Oregon in 2020 and Colorado in 2022 was associated with increased 12-month psilocybin use compared with synthetic control estimates.
https://ja.ma/4euVczy
Antibody titers elicited by the current inactivated influenza vaccine were modest against #Influenza A(H3N2) subclade K compared to responses against prior H1N1 and H3N2 strains.
https://ja.ma/3QkIDgh
State-level decriminalization of #Psilocybin in Oregon in 2020 and Colorado in 2022 was associated with increased 12-month psilocybin use compared with synthetic control estimates. https://ja.ma/4sE4o8d
Antibody titers elicited by the current inactivated influenza vaccine were modest against #Influenza A(H3N2) subclade K compared to responses against prior H1N1 and H3N2 strains. https://ja.ma/3QEkGAv
Kylie Cooper, MD, and Daniel Breitkopf, MD, both from the Mayo Clinic, discuss ways to reduce maternal morbidity and mortality and improve neonatal outcomes with JAMA Senior Editor Karen Lasser, MD, MPH. https://ja.ma/4sFsek5
💬 Perspective: The FDA’s Roadmap to Reducing Animal Testing advances #NewApproachMethodologies as alternatives to routine animal studies, reflecting scientific, ethical, and regulatory shifts in preclinical drug safety evaluation.
https://ja.ma/41JZlYR
US state-level policy responses to shifting federal guidance varied widely in 2025, with most states acting to preserve #COVID19 vaccination access through standing orders, insurance coverage, or clinician authority.
https://ja.ma/4mKPgEU
#Prepregnancy care and counseling encompass a range of interventions to improve #maternal and #neonatal outcomes. Worldwide, 1.9 billion individuals are eligible for reproductive health care.
📌 This JAMA Review summarizes the current evidence for prepregnancy care and counseling with a primary care focus.
https://ja.ma/48cgk9W
📊 Research Summary: Game-based training improved adherence to trauma triage guidelines for older adults in emergency departments, without increasing overtriage or affecting 30-day mortality or readmission.
https://ja.ma/48WJh9Y
A theory-based (serious) game reduced undertriage of older adults with severe #Trauma by emergency physicians in nontrauma centers, compared with usual education, without increasing overtriage.
https://ja.ma/42huQcS
Among adults with #AcuteSinusitis, standard-dose amoxicillin-clavulanate did not reduce treatment failure compared with amoxicillin, while overall failure and hospitalization rates were low in both groups.
https://ja.ma/3OPVsyD
Children with prior #CerebralMalaria or severe malarial anemia had lower long-term cognitive ability and math achievement than unaffected children when assessed up to 15 years later, while attention and reading scores were similar.
https://ja.ma/4dYjRMQ
💬 Editorial: Robinson et al evaluated hospital adoption and pricing for oncology biosimilars, finding that declining acquisition prices benefited hospitals and insurers, but adoption remained slow and markup margins persisted.
https://ja.ma/4vzdAgJ
Declining acquisition prices for #Biosimilars led to higher hospital markup margins and rapid increase in biosimilar adoption for bevacizumab, trastuzumab, and rituximab between 2020 and 2024.
https://ja.ma/4evMVez
I wrote this in a moment I never would have chosen. A sudden pause that made me see my life clearly.
The meaning of our work is profound. This experience simply helped me see more clearly what matters most.
“Time is Finite” JAMA
https://jamanetwork.com/journals/jama/article-abstract/2847647
💬 Perspective: The Great Healthcare Plan introduces policies like most-favored-nation drug pricing and PBM reform, but anticipated impacts on health care costs and coverage are limited.
https://ja.ma/4dQLU0y
⏱️Tenecteplase for Acute Non–Large Vessel Occlusion 4.5 to 24 Hours After Ischemic Stroke
The OPTION Randomized Clinical Trial from JAMA
🔓 Free to read online during #AAN2026
https://ja.ma/4cjgZJ5
Robert Wachter, MD, spoke with JAMA+ AI Editor-in-Chief Roy Perlis, MD, MSc, about how #GenerativeAI tools are already ubiquitous among trainees and clinicians and what's next for digital platforms in #medicine.
🎧 Listen now: https://ja.ma/4cyir9n
R to @JAMA_current: From @JAMANetworkOpen: In a pre-planned exploratory analysis of the DOTS RCT, achieving a total day-22 dalbavancin concentration >32 µg/mL was associated with higher rates of clinical success in patients with complicated Staphylococcus aureus bacteremia.
http://ja.ma/3Qlu1x6
R to @JAMANetworkOpen: Among adults with #AcuteSinusitis, standard-dose amoxicillin-clavulanate did not reduce treatment failure compared with amoxicillin, while overall failure and hospitalization rates were low in both groups.
#ESCMIDGlobal2026
https://ja.ma/4ufKxxx
R to @JAMANetworkOpen: Children with prior #CerebralMalaria or severe malarial anemia had lower long-term cognitive ability and math achievement than unaffected children when assessed up to 15 years later, while attention and reading scores were similar.
#ESCMIDGlobal2026
https://ja.ma/41KnnD5
R to @JAMANetworkOpen: 💬 Editorial: Children surviving cerebral #malaria or severe malarial anemia face long‑term cognitive and academic deficits years after infection, highlighting that the burden of #Malaria extends far beyond hospital discharge.
#ESCMIDGlobal2026
https://ja.ma/3QNgQVN
R to @JAMANetworkOpen: 📊 Research Summary: In patients with #GramNegativeBacteremia, rapid #AntimicrobialSusceptibilityTesting did not improve 30-day outcomes compared with standard testing, although it supported faster antibiotic adjustments.
#ESCMIDGlobal2026
https://ja.ma/4sERdDW
R to @JAMANetworkOpen: 💬 Editorial: In a multinational trial, #RapidAST did not improve a composite clinical outcome but led to earlier antibiotic optimization and shorter hospitalization in patients with resistant gram‑negative infections.
#ESCMIDGlobal2026
https://ja.ma/4vBO7Dv
📣 #ESCMIDGlobal2026 attendees, check out these findings from JAMA and @JAMANetworkOpen:
Among patients with #GramNegativeBacteremia, rapid #AntimicrobialSusceptibilityTesting did not improve 30-day clinical outcomes compared with standard testing, despite providing faster guidance for antibiotic escalation or deescalation.
https://ja.ma/4sL7JlU
Presented at #ESCMIDGlobal2026: Among adults with #AcuteSinusitis, standard-dose amoxicillin-clavulanate did not reduce treatment failure compared with amoxicillin, while overall failure and hospitalization rates were low in both groups.
https://ja.ma/4mG3Zkg
Presented at #ESCMIDGlobal2026:
💬 Editorial: Children surviving cerebral #malaria or severe malarial anemia face long‑term cognitive and academic deficits years after infection, highlighting that the burden of #Malaria extends far beyond hospital discharge.
https://ja.ma/4vEqmdY
Presented at #ESCMIDGlobal2026: Children with prior #CerebralMalaria or severe malarial anemia had lower long-term cognitive ability and math achievement than unaffected children when assessed up to 15 years later, while attention and reading scores were similar.
https://ja.ma/4tR4WbJ