Medications can decrease risk of withdrawal, overdose, and death in people with opioid use disorder.
📄 This JAMA Patient Page describes medications used to treat opioid use disorder, opioid withdrawal, and opioid overdose.
https://ja.ma/4lHLoUr
Opioid use disorder is a chronic disease characterized by a maladaptive pattern of opioid use despite negative consequences.
📌 This JAMA Clinical Guidelines Synopsis summarizes the 2024 CRISM guideline on management of opioid use disorder.
https://ja.ma/4uDONb8
The FDA recently cleared a new smartwatch #hypertension notification feature for the Apple Watch. In this study, researchers applied performance metrics to nationally representative US survey data to better understand the potential population impact.
https://ja.ma/4sORx3y
An estimated 61 million people used unregulated #opioids in 2023 worldwide.
This Review discusses the efficacy, safety, and practical considerations of treating patients with medications for #opioid use disorder, opioid withdrawal, and opioid overdose.
https://ja.ma/4buQX43
Moderate consumption of caffeinated coffee or tea was linked to reduced #dementia risk and modest improvements in #cognitive outcomes; no benefit was seen for decaffeinated coffee in an observational study of US adults.
https://ja.ma/40ENw5I
💬 Perspective: The Great Healthcare Plan introduces policies like most-favored-nation drug pricing and PBM reform, but anticipated impacts on health care costs and coverage are limited.
https://ja.ma/474VIQt
Among adults with multiorgan metastatic #ColorectalCancer, adding local debulking to chemotherapy did not improve survival and increased serious adverse events.
https://ja.ma/3PeCAt1
📊 Research Summary: Adding #acetaminophen (#paracetamol) or #hydromorphone to #ibuprofen did not improve pain relief for children with acute limb injuries; hydromorphone led to more adverse events.
https://ja.ma/4rBvVGP
📊 Research Summary: Adding #acetaminophen (#paracetamol) or #hydromorphone to #ibuprofen did not improve pain relief for children with acute limb injuries; hydromorphone led to more adverse events.
https://ja.ma/4rL97ok
Last week, Yulin Hswen, ScD, MPH, Associate Editor at JAMA and JAMA+ AI, presented at @theNASEM workshop on Policy Issues for Integrating #ArtificialIntelligence in #Cancer Research and Care.
🎥 Watch the full workshop recording here:
https://ja.ma/4dlcSNu
In this episode of JAMA+ AI Conversations, Editor in Chief Roy Perlis and Associate Editor Yulin Hswen debate recent articles highlighted in JAMA+ AI, including work on patient messaging and suicide screening, plus a call for more critical thinking in medicine.
https://ja.ma/40vJXih
R to @JAMA_current: 💬 Editorial: Routine physical restraints in mechanically ventilated ICU patients did not alter delirium, self-extubation, or mortality rates; individualized assessment is imperative in #CriticalCare.
🔗 https://ja.ma/4rD8Tzr
#ISICEM26 #ICUCommunity @ISICEM
R to @JAMA_current: 📊 Research Summary: Restrictive vs liberal wrist-strap restraint strategies in ICU patients receiving mechanical ventilation produced similar outcomes for delirium, coma, self-extubation, and mortality.
🔗 https://ja.ma/4sflrOo
#ISICEM26 #ICUCommunity @ISICEM
A restrictive (lower use) wrist-strap restraint approach did not improve #delirium-free or #coma-free days compared to liberal use in mechanically #ventilated #ICU patients. 🧵
🔗 https://ja.ma/4bsVTX8
#ISICEM26 #ICUCommunity @ISICEM
💬 Perspective: Cuts to social welfare, health agencies, and data surveillance are projected to increase mortality rates and escalate the US health disadvantage relative to other nations.
https://ja.ma/4bgWA5u
💬 Perspective: The Great Healthcare Plan introduces policies like most-favored-nation drug pricing and PBM reform, but anticipated impacts on health care costs and coverage are limited.
https://ja.ma/46WyBaI
Current early detection strategies for #Sepsis focus on hospitalized patients, but most cases begin days earlier in the community. Smart technology could help detect and manage sepsis before hospital admission.
JAMA Senior Editor Derek C. Angus, MD, MPH, discusses 5 areas of research that could benefit care for critically ill patients.
🎥 Watch the full video: https://ja.ma/4uvtE2F
💬 Editorial: The ORCHESTRA trial demonstrated that surgical or ablative debulking strategies in multiorgan metastatic #ColorectalCancer do not improve overall or progression-free survival when added to #chemotherapy.
https://ja.ma/47ygojO
📊 Research Summary: Among patients with multiorgan metastatic #ColorectalCancer, tumor debulking combined with systemic chemotherapy failed to provide a survival benefit over chemotherapy alone and resulted in higher rates of serious adverse events.
https://ja.ma/4sok2oI
Among adults with multiorgan metastatic #ColorectalCancer, adding local debulking to chemotherapy did not improve survival and increased serious adverse events.
https://ja.ma/47vpg9W
Antibody titers elicited by the current inactivated influenza vaccine were modest against #Influenza A(H3N2) subclade K compared to responses against prior H1N1 and H3N2 strains.
https://ja.ma/4lBPJsq
📊 Research Summary: Early use of automated closed-loop ventilation did not increase ventilator-free days at day 28 compared with protocolized conventional ventilation.
https://ja.ma/4uxFauc
💬 This Perspective discusses how clinicians can navigate conflicting #vaccination recommendations following revisions from the Advisory Committee on Immunization Practices and US Centers for Disease Control and Prevention.
https://ja.ma/4cPiboi
In under 10 minutes, JAMA Deputy Editors Linda Brubaker, MD, and Preeti Malani, MD, MSJ, discuss the latest science published in JAMA:
➡️ Pricing and Adoption of ##Oncology Biosimilars,
➡️ #Flu Immunity After #Immunization,
➡️ #Psilocybin Use After Decriminalization, and more.
🎧 Listen now: https://ja.ma/4uueVVv
Declining acquisition prices for #Biosimilars led to higher hospital markup margins and rapid increase in biosimilar adoption for bevacizumab, trastuzumab, and rituximab between 2020 and 2024.
https://ja.ma/4bu4mJC
Allergy to peanuts affects approximately 2% of individuals in the US.
💡 This JAMA Insights discusses #PeanutAllergy, including diagnosis, introduction of peanuts to infant diet, and #immunotherapy options.
https://ja.ma/4bnHMCf
💬 Editorial: Nearly 3 million #MedicareAdvantage beneficiaries face coverage disruption in 2026 due to plan exits, most affecting rural areas and smaller carriers.
https://ja.ma/4bbKBHV
Forced disenrollment from #MedicareAdvantage plans will reach 10% in 2026, affecting millions—particularly those in rural areas, PPOs, and lower-rated plans.
https://ja.ma/4sbAaKt
#PrEP, or pre-exposure prophylaxis, is changing #HIV prevention in the US, with expanded options including daily oral tablets, long-acting injectables, and on-demand regimens.
Jennifer Abbasi, Director of JAMA Medical News, and Associate Managing Editor Kate Schweitzer discuss how coverage has grown to nearly 600 000 patients while regions with higher PrEP uptake report the largest declines in new #HIV infections.
🎧 Listen now: https://ja.ma/47HwkjK
Among same-sex female couples, reciprocal and autologous #IVF cycles yielded similar pregnancy and live birth rates, supporting reciprocal IVF as an effective option.
https://ja.ma/412PlcG
💬 Viewpoint: Preemption of state medical #AI laws by executive order challenges constitutional limits and risks undermining innovation and patient protections; congressional action is required for federal policy.
https://ja.ma/3NnUadp
In adults receiving heart transplants after donor circulatory death, rapid recovery with extended ultraoxygenated preservation enabled safe use of hearts from older donors and with longer ischemic times, with high short-term survival and low complications.
https://ja.ma/4drtLpE
PrEP has transformed #HIV prevention in the US, but recent funding cuts may threaten access. https://ja.ma/4lB9d07
South Asian adults in the US develop cardiovascular disease risk factors earlier than other groups, according to new research from the MASALA cohort study. Here’s what that means for prevention. https://ja.ma/3NCyudL
#AI-powered tools are rapidly transforming the work of doctors, trainees, and clinical leaders. Platforms like Open Evidence, GPT-based scribes, and integrated EHR solutions now provide real-time consults, note summarization, and even help with administrative tasks.
Robert Wachter, MD, Chair of Medicine at UCSF and author of the new book "A Giant Leap: How AI is Transforming Healthcare and What That Means for Our Future," spoke with JAMA+ AI Editor-in-Chief Roy Perlis, MD, MSc, about how #GenerativeAI tools are already ubiquitous among trainees and clinicians and what's next for digital platforms in #medicine.
🎧 Listen now: https://ja.ma/4sbMfiK
State-level decriminalization of #Psilocybin in Oregon in 2020 and Colorado in 2022 was associated with increased 12-month psilocybin use compared with synthetic control estimates.
https://ja.ma/4ltQfZi
💬 Perspective: National reviews of controlled organ donation highlight the need for serial neurobehavioral evaluations and minimum neurologically informed standards to ensure ethical, patient-centered practice.
https://ja.ma/4rxFmqX
🌎 Global #cardiology societies released their first joint statement urging action on environmental risk factors for cardiovascular disease, including air pollution, heat, and noise.
https://ja.ma/4rp9LYd
"I found the lump myself. Pebble-sized. Firm. Uninvited."
🖋️ In #APieceofMyMind, a hematologist and endurance athlete discovers an aggressive #BreastCancer.
https://ja.ma/4b5AZyj
Robert Wachter, MD, chair of the Department of Medicine at UC San Francisco, speaks with JAMA+ AI Editor in Chief Roy Perlis, MD, MSc, about his new book, “A Giant Leap.”
https://ja.ma/4s5NKyK