📊 Research Summary: Among adults with major depressive disorder, use of a web-based decision-support tool reduced early #antidepressant discontinuation and improved symptoms compared with usual care.
https://ja.ma/4csLXgP
Med News: Could lithium help treat #Alzheimer disease?
A recent pilot study of patients with mild cognitive impairment sets the stage for larger trials.
https://ja.ma/4swjtZh
📌 Editor’s Choice from this week's issue of JAMA:
➡️ Chronic #Diarrhea Review,
➡️ Restrictive vs Liberal #ICU Physical Restraint,
➡️ Web-Based #Antidepressant Decision Tool, and more.
https://ja.ma/4vsS7WD
Adrenal insufficiency occurs when the adrenal glands do not produce adequate amounts of certain essential hormones.
This JAMA Patient Page describes the types of adrenal insufficiency and its symptoms, diagnosis, and treatment. https://ja.ma/3OG2tSy
The frequency and intensity of heatwaves and the exposure of pregnant individuals to extreme heat are increasing.
💡 Learn more about the associated risks to maternal health and how these risks can be managed in this JAMA Insights. #ClimateChange https://ja.ma/481fnkN
📊 Research Summary: Restrictive vs liberal wrist-strap restraint strategies in ICU patients receiving mechanical ventilation produced similar outcomes for delirium, coma, self-extubation, and mortality.
https://ja.ma/4sueKY3
Chronic #diarrhea is defined by recurrent loose or watery stools, with or without increased stool frequency, fecal urgency, or fecal incontinence, that lasts for at least 4 weeks.
📄 Learn more about diagnosis and treatment strategies in this Review: https://ja.ma/4tacJ4x
💬 Editorial: Personalized #antidepressant selection using clinical criteria and patient preferences may yield better outcomes than biomarker-driven approaches for #depression.
https://ja.ma/4mzvWKG
In adults with major depressive disorder, the PETRUSHKA tool, which combines patient preferences and clinical predictors, was effective in personalizing antidepressant treatment and increased the likelihood of continuing treatment through 8 weeks.
https://ja.ma/4sRMZct
After the FDA removed in-person dispensing requirements, pharmacy-based #mifepristone use rose sharply via mail order in states where abortion and telehealth are permitted.
https://ja.ma/4dGhZbk
In patients with symptomatic, severe tricuspid regurgitation treated in routine US practice, transcatheter tricuspid valve replacement resulted in high implant success, significant symptom relief, and health status gains.
https://ja.ma/3QjjceT
Current allocations under the Rural Health Transformation Program are inversely associated with rural mortality and hospital bed losses, indicating that funding may not reflect clinical need.
https://ja.ma/4mBbDwo
Join a free public webinar with Therese S. Richmond, PhD, RN, lead author of the JAMA Summit Report on Firearm Violence, discussing key findings and recommendations from the report.
📅 Apr 15 | 12-1:15 PM ET
🔗 Register: https://bit.ly/4re93gm
Patients with #EndometrialCancer commonly present with abnormal uterine bleeding, with diagnosis established by endometrial biopsy and management guided by disease stage, histology, and molecular subtype.
In under 15 minutes, JAMA Senior Editor Karen Lasser, MD, and gynecologic oncologist Karen McLean, MD, discuss key risk and protective factors, hereditary syndromes, racial disparities in diagnosis, and current surgical, chemotherapy, and immunotherapy strategies shaping clinical care.
🎧 Listen now: https://ja.ma/3QhlTh1
💬 Viewpoint: Utah authorized the first autonomous #AI drug prescriber for nearly 200 medications, bypassing physician oversight and FDA review, raising questions about safety and regulatory gaps.
https://ja.ma/4cmPAET
This JAMA Patient Page describes common symptoms and signs of #endometrial #cancer, how it is diagnosed and treated, and the prognosis.
https://ja.ma/4t9ef7a
Uterine cancer is the fourth most common cancer in women in the US, with an estimated 68 270 new cases and 14 450 cancer deaths projected to occur in 2026.
📄 This Review summarizes the epidemiology, clinical presentation, and diagnosis of endometrial cancer.
https://ja.ma/4vJ6h6v
After the FDA removed in-person dispensing requirements, pharmacy-based #mifepristone use rose sharply via mail order in states where abortion and telehealth are permitted.
https://ja.ma/4sr5Jir
In their 2025 Year in Review Editorial, JAMA editors reflect on a year of rapid change in medicine and public health, highlighting a continued commitment to rigorous evidence, global engagement, timely publication, and advancing scientific integrity to inform patient care.
https://ja.ma/3QBk9iL
In patients with symptomatic, severe tricuspid regurgitation treated in routine US practice, transcatheter tricuspid valve replacement resulted in high implant success, significant symptom relief, and health status gains.
https://ja.ma/4mnNBES
💬 Viewpoint: Judicial decisions narrowing the “skinny label” pathway for generics threaten affordable medicines and reduce timely competition for multi-indication drugs.
https://ja.ma/4cFKtks
💬 Editorial: For adults ≥75 years, 10-year #ColorectalCancer risk after adenoma removal is low and far exceeded by non-CRC mortality, supporting deprioritizing routine surveillance colonoscopy.
https://ja.ma/4t2lNs8
💬 Editor's Note: #Adolescents face increasing rates of insufficient sleep, driven by early school start times and digital media use, undermining cognitive and mental health.
https://ja.ma/4szamXL
Clinical research from the @ACCinTouch 2026 Scientific Sessions assessed #cardiovascular prevention strategies, post-myocardial infarction medication use, long #COVID POTS, and #shingles vaccination.
JAMA Medical News Director Jennifer Abbasi spoke with ACC Conference Chair Katie Berlacher, MD, about how these findings may inform #CardiovascularDisease care.
🎧 Listen now: https://ja.ma/4cJkGa7
An estimated 1.1 million to 1.9 million #pediatric concussions occur annually in the US.
📊 This JAMA Rational Clinical Examination reviews the diagnostic accuracy of symptoms and signs observed in the initial evaluation of a child or adolescent who may have had a #concussion.
https://ja.ma/4vrdjwo
Manufacturer-sponsored coupon use for brand-name drugs declined from 2017 to 2024 among US patients, but per-claim coupon amounts increased, especially for #Obesity and #Diabetes therapies.
https://ja.ma/4t8e9g4
In this podcast, JAMA Deputy Editors Linda Brubaker, MD, and Preeti Malani, MD, MSJ, discussed the latest science published in JAMA:
➡️ Discontinuing Levothyroxine in Older Adults,
➡️ Cost-Effectiveness of Laboratory Goals for Lipid-Lowering Therapy,
➡️ CRC Screening for Older Adults, and more.
🎧 Listen now: https://ja.ma/4tJQWk9
💬 Viewpoint: Administrative delays and access failures introduce patient safety risks but are rarely treated as safety events in health systems.
https://ja.ma/4c2Yvwk
Insufficient #sleep among US high school students increased from 2007 to 2023, with the rise driven largely by more adolescents reporting very short sleep durations of ≤5 hours per night. https://ja.ma/4s5iFdH
💬 Viewpoint: Administrative delays and access failures introduce patient safety risks but are rarely treated as safety events in health systems. https://ja.ma/4s7PTZZ
From 2015 to 2023, long-term #opioid therapy declined by 24% in the US, but 4.2 million patients remained on long-term opioids, with trends toward older age and increased #Medicare coverage.
https://ja.ma/47WVmvv
📊 JAMA Clinical Guidelines Synopsis: #CrohnDisease guidelines recommend fecal calprotectin for screening and monitoring, routine colonoscopy for colorectal cancer, and oral budesonide for induction in mild to moderate ileocecal disease.
https://ja.ma/3Qgm8ca
A computer simulation found #ApoB-guided intensification of lipid-lowering therapy provides the most QALYs and is highly cost-effective compared to #LDL-C or #nonHDL-C targets.
https://ja.ma/4tDsxwm
#AI scribe adoption across 5 academic centers was associated with modest reductions in EHR and documentation time, plus a slight increase in weekly visit volume, especially for primary care and female clinicians.
https://ja.ma/4vi6HAh
The 2025 US Perinatal Guidelines designate bictegravir as a preferred antiretroviral regimen for patients with #HIV during pregnancy, supported by safety and efficacy data.
💡 Learn more in this JAMA Insights: https://ja.ma/47QoYe3
💬 Viewpoint: Regulatory uncertainty regarding donation after circulatory death and normothermic regional perfusion is shaping clinical practice and limiting adoption, particularly for lung transplants.
https://ja.ma/47Td6ba
A deeply personal, beautiful and heartwrenching piece published yesterday in @JAMA_current from one of the giants of #PedsICU and pediatric #ECMO. A must read-- but have tissues and a quiet place available. Thank you @FortenberryMD for sharing with the world. ❤https://jamanetwork.com/journals/jama/fullarticle/2847310
Med News: Explore the top clinical highlights from #ACC26.
In this Q&A, conference chair Katie Berlacher, MD, MS, discusses PCSK9 inhibitors, the shingles vaccine, and more.
https://ja.ma/4tCWfll
Med News: Could mRNA vaccines help treat cancer?
Find out more about the latest research on this experimental personalized therapy, designed to train the immune system to recognize and destroy cancer cells.
https://ja.ma/3OkNRI2
Med News: PrEP has transformed #HIV prevention in the US, but recent funding cuts may threaten access.
https://ja.ma/3QwJw5e