State-level decriminalization of #Psilocybin in Oregon in 2020 and Colorado in 2022 was associated with increased 12-month psilocybin use compared with synthetic control estimates.
https://ja.ma/4rspQwj
💬 Viewpoint: Federal food safety laws set national standards but preserve state authority to ban harmful ingredients and require warnings. State actions help fill gaps in #FDA oversight.
https://ja.ma/4b68pg9
💬 Editorial: Sinnige et al demonstrate that closed-loop ventilation did not improve ventilator-free days compared to conventional care.
Questions remain regarding how best to integrate adaptive ventilation systems into real-world practice.
https://ja.ma/4ul4qUF
RCT: Among critically ill adults receiving invasive mechanical ventilation, early use of an automated closed-loop ventilation system did not increase ventilator-free days at day 28 compared with protocolized conventional ventilation.
https://ja.ma/4cIwzyA
#Influenza A(H3N2) subclade K, now predominant in the US, elicits lower vaccine-induced #antibody responses compared with other recent strains. These findings indicate partial immune escape and may inform future #vaccine strain selection.
🔗 https://ja.ma/4bCzcAW
Proud of this collaboration with Victor Hassid @UTMDAnderson:
Should we treat administrative & insurance delays in patient care access as Safety Events warranting rigorous root cause analyses, M&M discussions, and quality improvement interventions?
💬 Viewpoint: Administrative delays and access failures introduce patient safety risks but are rarely treated as safety events in health systems.
https://ja.ma/4ljWHSu
#PeanutAllergy involves an immune reaction to peanuts that may cause skin, gastrointestinal, respiratory, and cardiovascular symptoms, and can cause severe allergic reactions.
📄 Learn more in this JAMA Patient Page: https://ja.ma/4rnwjZu
Allergy to peanuts affects approximately 2% of individuals in the US.
💡 This JAMA Insights discusses #PeanutAllergy, including diagnosis, introduction of peanuts to infant diet, and #immunotherapy options.
https://ja.ma/4cGKchD
💬 Editorial: Robinson et al evaluated hospital adoption and pricing for oncology biosimilars, finding that declining acquisition prices benefited hospitals and insurers, but adoption remained slow and markup margins persisted.
https://ja.ma/4lsrq00
Declining acquisition prices for #Biosimilars led to higher hospital markup margins and rapid increase in biosimilar adoption for bevacizumab, trastuzumab, and rituximab between 2020 and 2024.
https://ja.ma/4sBVgBp
#Obesity is associated with higher risk for 12 #cancer types and accounts for approximately 10% of annual new cancer cases in the US.
📄 This Review summarizes the primary biological pathways connecting obesity and cancer development.
https://ja.ma/4udHE0K
Antibody titers elicited by the current inactivated influenza vaccine were modest against #Influenza A(H3N2) subclade K compared to responses against prior H1N1 and H3N2 strains.
https://ja.ma/4bzdtK6
Prostatitis involves infection, inflammation, or pain in the prostate gland and affects about 9% of men during their lifetime.
📄 This JAMA Patient Page describes the types of prostatitis and its risk factors, diagnosis, and treatment.
https://ja.ma/4bhrzyj
Prostatitis involves infection, inflammation, or pain in the prostate gland and affects about 9% of men during their lifetime.
📄 This JAMA Patient Page describes the types of prostatitis and its risk factors, diagnosis, and treatment.
https://ja.ma/4swEjbs
The presence of ICE agents in and around medical settings is keeping some US immigrants—both documented and undocumented—away, disrupting care and putting their health at risk.
https://ja.ma/3PtVRXq
📌 Editor’s Choice from this week's issue of JAMA:
➡️ Ibuprofen vs Combo Therapy for Pediatric Musculoskeletal Pain,
➡️ Reducing Ovarian Cancer Risk Through Opportunistic Fallopian Tube Removal,
➡️ Pharmaceutical Pricing—JAMA Talks With Mark Cuban, and more.
https://ja.ma/4ljpVRu
Cesarean delivery on maternal request accounts for 2.5% of US births and is linked to lower rates of #PelvicFloorDisorders, but increased future risks such as placenta accreta and hysterectomy.
💡 Learn more in this JAMA Insights: https://ja.ma/46RD9yY
How can the #prescription drug market be more efficient?
@mcuban, entrepreneur, investor, and cofounder of the @costplusdrugs, joined JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss the role of #pharmacy benefit managers, #insurance formularies, and opaque pricing practices that shape how most Americans access prescription drugs.
🔗 Watch video excerpts from the discussion and listen to the podcast: https://ja.ma/4urgOCA
📢 Special Communication: Opportunistic salpingectomy during pelvic or selected abdominal #surgery is associated with lower risk of tubo-ovarian #carcinoma and minimal surgical risk, but data on long-term ovarian function remain limited.
https://ja.ma/3NrgaEm
💬 Editorial: Randomized clinical trials by Ali et al found no incremental benefit of hydromorphone over ibuprofen for acute musculoskeletal pain in children and adolescents and highlighted higher rates of adverse events with opioid use.
https://ja.ma/46PaJFY
For children with acute nonoperative limb injuries, pain scores did not improve with addition of either #acetaminophen (paracetamol) or #hydromorphone to #ibuprofen; adverse events were higher with hydromorphone.
https://ja.ma/4sAMPGr
Cesarean delivery on maternal request accounts for 2.5% of US births and is linked to lower rates of #PelvicFloorDisorders, but increased future risks such as placenta accreta and hysterectomy. 💡 Learn more in this JAMA Insights: https://ja.ma/4rT5mhe
JAMA and JAMA Network Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, spoke with Mark Cuban, entrepreneur and cofounder of the Mark Cuban Cost Plus Drugs Company, about pharmaceutical pricing. https://ja.ma/4syhVOP
Obesity and overweight are risk factors for several types of cancer. Why?
A @JAMA_current review
https://jamanetwork.com/journals/jama/fullarticle/2846256?guestAccessKey=1bff0b67-8834-40ec-a733-badb705c67c1&utm_medium=email&utm_source=postup_jn&utm_campaign=article_alert-jama&utm_content=olf-tfl_&utm_term=030926
Our group's viewpoint piece on the effects of recent regulatory uncertainty on DCD procurement practices, a good read for those interested in thoracic transplantation @CUECMO
Author Neil Iyengar, MD, of Emory University discusses the biological pathways that may promote cancer in people with overweight or obesity and potential therapies with JAMA Deputy Editor Mary McDermott, MD. https://ja.ma/47k1D40
💬 Viewpoint: Regulatory uncertainty regarding donation after circulatory death and normothermic regional perfusion is shaping clinical practice and limiting adoption, particularly for lung transplants.
https://ja.ma/4bxmROo
#Obesity is associated with higher risk for 12 #cancer types and accounts for approximately 10% of annual new cancer cases in the US.
📄 This Review summarizes the primary biological pathways connecting obesity and cancer development. https://ja.ma/3OPhtgT
💬 Viewpoint from FDA: Makary and coauthors discuss streamlined FDA guidance for biosimilars that aims to lower development barriers and support pharmacy-level substitution, promoting access and affordability for patients needing biologic medications.
https://ja.ma/46Oxs4U
Antibody titers elicited by the current inactivated influenza vaccine were modest against #Influenza A(H3N2) subclade K compared to responses against prior H1N1 and H3N2 strains.
https://ja.ma/40S9mCN
#AI tools are changing how patients access health info.
From explaining medical terms to proving postoperative instructions to digitizing informed consent, experts explore how these technologies may serve as “clinician extenders.”
https://ja.ma/4dbCT1z
Current allocations under the Rural Health Transformation Program are inversely associated with rural mortality and hospital bed losses, indicating that funding may not reflect clinical need.
https://ja.ma/4liPFO1
In adults with major depressive disorder, the PETRUSHKA tool, which combines patient preferences and clinical predictors, was effective in personalizing antidepressant treatment and increased the likelihood of continuing treatment through 8 weeks.
https://ja.ma/46NaV8u
💡 JAMA Insights: Numeric risk comparisons anchored in patient context may improve shared decision-making and help patients interpret clinical choices.
https://ja.ma/4bwOmHR
Just some of the fabulous women leaders I have the good fortune of working with at @JAMA_current & @JAMANetwork!
#InternationalWomensDay
In under 10 minutes, JAMA Deputy Editors Linda Brubaker, MD, and Preeti Malani, MD, MSJ, discuss the latest science published in JAMA:
➡️ Personalized Antidepressant Decision-Support,
➡️ Insufficient Sleep in Adolescents,
➡️ Rural Health Funding, and more.
🎧 Listen now: https://ja.ma/47lFsdN
Current allocations under the Rural Health Transformation Program are inversely associated with rural mortality and hospital bed losses, indicating that funding may not reflect clinical need.
https://ja.ma/4cxeT95
In WISDOM, researchers compared risk-based breast cancer screening to standard annual mammography among more than 28 000 US women aged 40 to 74 across all 50 states.
https://ja.ma/4uk8Uec
🌙 Heart attacks tend to be less severe at night, but why?
https://ja.ma/4cyyeXs