Fertility preservation guidance from the American Society of Clinical Oncology supports timely counseling on fertility risks for all patients with cancer.
Learn more in this JAMA Clinical Guidelines Synopsis: https://ja.ma/3Oh9rNM
Concerned about research ethics in the current landscape? In this 2026 Research Ethics Day video, Dr. Christine Grady & Dr. Kirsten Bibbins-Domingo analyze emerging threats to research ethics & integrity and consider opportunities to meet those challenges. https://youtu.be/83U_67ZJtG8?si=KsGnflXBgJoUIqWJ
💬 Viewpoint: Judicial decisions narrowing the “skinny label” pathway for generics threaten affordable medicines and reduce timely competition for multi-indication drugs.
https://ja.ma/4eaNVof
In this episode of JAMA+AI Conversations, integrative epidemiologist Fang Fang, MD, PhD, discusses how #AI can illuminate hidden trajectories and enhance causal inference in the epidemiology of complex diseases using population-scale data.
https://ja.ma/4cdPorj
"I knew other medical colleagues who could never return to the hospital where they had lost a child or loved one, and I understood."
In #APieceofMyMind, a #pediatric #CriticalCare #physician reflects on the death of his infant grandson.
https://ja.ma/4vzxVTk
💬 Editorial: For adults ≥75 years, 10-year #ColorectalCancer risk after adenoma removal is low and far exceeded by non-CRC mortality, supporting deprioritizing routine surveillance colonoscopy.
https://ja.ma/4tBs9hY
In adults ≥75 years, 10-year #ColorectalCancer and CRC death risk were higher with prior adenoma but both were low (<1.1%); non-CRC death risk was 47-48%, supporting deprioritizing repeat surveillance.
https://ja.ma/48luTb8
"It would change the face of managing critical illness."
JAMA Senior Editor Derek C. Angus, MD, MPH, outlines 5 areas of critical care research that could reshape how we care for critically ill patients, from early detection to smarter technology and human-centered care.
🎥 Watch the full video: https://ja.ma/4tyZsCr
💬 Editorial: For patients with 5 to 20 brain metastases, stereotactic radiosurgery reduced symptom severity and preserved function vs hippocampal-avoidance whole brain radiotherapy, supporting its role as a standard approach.
https://ja.ma/4ss0wa5
Among adults undergoing cardiac imaging for #CoronaryArteryDisease, radiation dose varied widely and was higher for CCTA in low-income countries. The findings suggest a need for standardized protocols to reduce exposure.
https://ja.ma/3Q1uaFM
Among adults undergoing cardiac imaging for #CoronaryArteryDisease, radiation dose varied widely and was higher for CCTA in low-income countries. The findings suggest a need for standardized protocols to reduce exposure. https://ja.ma/41cCZPq
South Asian adults in the US develop cardiovascular disease risk factors earlier than other groups, according to new research from the MASALA cohort study. Here’s what that means for prevention. https://ja.ma/4t8wSIt
💬 Viewpoint: The Health Data, Technology, and Interoperability (HTI-5) proposed rule expands EHI access, but workflow blocking limits real-time usability of #AI tools in clinical care.
https://ja.ma/4t66r6a
From 2015 to 2023, long-term #opioid therapy declined by 24% in the US, but 4.2 million patients remained on long-term opioids, with trends toward older age and increased #Medicare coverage.
https://ja.ma/41lIHPa
📊 JAMA Clinical Guidelines Synopsis: #CrohnDisease guidelines recommend fecal calprotectin for screening and monitoring, routine colonoscopy for colorectal cancer, and oral budesonide for induction in mild to moderate ileocecal disease.
https://ja.ma/41UNdnS
💬 Editorial: Simulation modeling demonstrates #ApoB-guided statin intensification is cost-effective, identifies more clinically meaningful risk, and aligns with 2026 ACC/AHA guidelines.
https://ja.ma/4vjZjEv
💬 Viewpoint: The Health Data, Technology, and Interoperability (HTI-5) proposed rule expands EHI access, but workflow blocking limits real-time usability of #AI tools in clinical care. https://ja.ma/41ciJxn
From 2015 to 2023, long-term opioid therapy declined by 24% in the US, but 4.2 million patients remained on long-term opioids, with trends toward older age and increased Medicare coverage. https://ja.ma/41ciK4p
📊 JAMA Clinical Guidelines Synopsis: #CrohnDisease guidelines recommend fecal calprotectin for screening and monitoring, routine colonoscopy for colorectal cancer, and oral budesonide for induction in mild to moderate ileocecal disease. https://ja.ma/4bLFONy
A computer simulation found #ApoB-guided intensification of lipid-lowering therapy provides the most QALYs and is highly cost-effective compared to #LDL-C or #nonHDL-C targets.
https://ja.ma/4meWnoy
📊 Research Summary: Stereotactic radiation provided better patient-reported quality of life and functional independence for patients with 5 to 20 brain metastases than hippocampal-avoidance whole brain radiation. https://ja.ma/41LKMUw
RCT: Among patients with 5 to 20 brain metastases, stereotactic radiation targeting individual tumors improved symptom severity and interference with daily functioning compared to hippocampal-avoidance whole brain radiation. https://ja.ma/3QgL3wc
💬 Viewpoint: The 2025-2030 Dietary Guidelines for Americans weakened evidence-based recommendations for plant-predominant diets, potentially impacting efforts to reduce #cardiovascular disease, #diabetes, and #obesity. https://ja.ma/41JEK6O
📌 Editor’s Choice from this week's issue of JAMA:
➡️ How BNP and Ultrasound Improve Volume Overload Detection,
➡️ Tenecteplase 4.5 to 24 Hours After Ischemic Stroke,
➡️ Stereotactic Radiation for Brain Metastases, and more.
https://ja.ma/41VB7e4
Among women worldwide, #OvarianCancer is the eighth most common malignancy and cause of cancer death.
📄 This JAMA Patient Page describes ovarian cancer and its risk factors, symptoms, diagnosis, and treatment.
https://ja.ma/41eEKM7
💬 Perspective: As #AI increasingly guides diagnosis, documentation, and patient management, physicians’ roles are changing, prompting questions about sustaining empathy, accountability, and trust in algorithmic care.
https://ja.ma/4soiuun
📊 Research Summary: In patients with non–large-vessel occlusion stroke and salvageable tissue, tenecteplase extended to 24 hours improved outcomes compared with standard care but increased bleeding risk.
https://ja.ma/4bUyFdR
In patients with non–large-vessel occlusion stroke and salvageable tissue, tenecteplase extended to 24 hours improved outcomes compared with standard care but increased bleeding risk.
https://ja.ma/4tyBqHH
How can volume overload be reliably excluded at the bedside?
📊 This Rational Clinical Examination evaluates the diagnostic accuracy of clinical examination, radiographic imaging, and laboratory testing in assessing volume overload in nonintubated patients.
https://ja.ma/4moSLjZ
Manufacturer-sponsored coupon use for brand-name drugs declined from 2017 to 2024 among US patients, but per-claim coupon amounts increased, especially for #Obesity and #Diabetes therapies.
https://ja.ma/3NNfcmf
An estimated 1.1 million to 1.9 million #pediatric concussions occur annually in the US.
📊 This JAMA Rational Clinical Examination reviews the diagnostic accuracy of symptoms and signs observed in the initial evaluation of a child or adolescent who may have had a #concussion.
https://ja.ma/3OlphH8
In adults ≥60 years, 26% discontinued levothyroxine while maintaining thyroid function, with 64% success for doses ≤50 μg/d, and no clinically important changes in thyroid-related symptoms.
https://ja.ma/4sX3RPy
JAMA Review author Sonal N. Shah, MD, MPH, of Boston Children’s Hospital, discusses #PediatricConcussion with JAMA Associate Editor David Simel, MD, MHS.
🎧 Listen now: https://ja.ma/4sdjQYz
Manufacturer-sponsored coupon use for brand-name drugs declined from 2017 to 2024 among US patients, but per-claim coupon amounts increased, especially for #Obesity and #Diabetes therapies.
https://ja.ma/4sfJax6
An estimated 1.1 million to 1.9 million #pediatric concussions occur annually in the US.
📊 This JAMA Rational Clinical Examination reviews the diagnostic accuracy of symptoms and signs observed in the initial evaluation of a child or adolescent who may have had a #concussion.
https://ja.ma/3PSI3Gn
R to @JAMA_current: 💬 Editorial: In older adults with subclinical #Hypothyroidism, deprescribing levothyroxine was feasible and safe, particularly for patients taking a dosage of ≤50 μg/d, with little impact on quality of life.
https://ja.ma/4c665oG
In adults ≥60 years, 26% discontinued levothyroxine while maintaining thyroid function, with 64% success for doses ≤50 μg/d, and no clinically important changes in thyroid-related symptoms. 🧵
https://ja.ma/41TS48I
Recent advances in the diagnosis and treatment of iron deficiency highlight its prevalence and health impact beyond #anemia.
Margaret Wheeler, MD, Associate Editor at JAMA, and Michael Auerbach, MD, clinical professor at Georgetown University, discuss updated strategies, at-risk populations, and effective management—including intravenous iron.
🎧 Listen now: https://ja.ma/4dOxM8b
💬 Viewpoint: Breast density increases cancer risk and reduces #Mammography sensitivity, but access to supplemental screening like #MRI and ultrasonography remains limited, creating disparities in early #BreastCancer detection.
https://ja.ma/4bSIXLB
Bone lead levels were directly associated with higher #CardiovascularDisease mortality, and lead was the eighth leading cause of death worldwide and second among environmental risks in 2023.
https://ja.ma/4dOxGgP