📊 JAMA Guide to Statistics and Methods: The Hochberg procedure is a multiplicity correction used in clinical trials to control the familywise error rate when comparing multiple end points.
Learn more: https://ja.ma/4leD6mA
AI-powered health tools are being adopted by patients, with platforms like ChatGPT Health and others now offering answers to health questions, explanations of postoperative care, and simplified clinical trial information.
JAMA Medical News Director Jennifer Abbasi spoke with Lead Senior Staff Writer Rita Rubin about ChatGPT Health, recently launched by OpenAI, and the expanding landscape of patient-facing generative AI applications.
🎧 Listen now: https://ja.ma/40gyi6Q
Keratinocyte carcinomas are skin cancers that develop in the outer layer of the skin.
📄 Learn more about the risk factors, signs and symptoms, diagnosis, and treatment in this JAMA Patient Page:
https://ja.ma/4lgzKQi
📊 Research Summary: The ImmunoSep trial demonstrates the potential for biomarker-guided immunotherapy in a subset of patients with sepsis.
https://ja.ma/4rVhQF7
Point-of-care ultrasonography allows accurate assessment of the internal jugular vein in patients with intravascular #VolumeOverload.
💾 Save this video for your next clinical encounter.
🔗 Read the full article: https://ja.ma/4crPnSx
💬 Perspective: #MedEd accreditation should shift from process-focused standards to outcome-based measures, with leadership from education experts ensuring assessment aligns with professional and public expectations.
https://ja.ma/4bc03m8
Grateful to @JAMA_current, @JAMAplusAI, and @RitaRubin for highlighting our work with @Pub2Post on addressing the gaps between patients and providers.
Full article: https://jamanetwork.com/journals/jama/fullarticle/2846269
#AI tools are changing how patients access health info.
From explaining medical terms to proving postoperative instructions to digitizing informed consent, experts explore how these technologies may serve as “clinician extenders.”
https://ja.ma/4uf3Kjk
📊 Research Summary: Among adults with major depressive disorder, use of a web-based decision-support tool reduced early #antidepressant discontinuation and improved symptoms compared with usual care.
https://ja.ma/4rX48lc
💡 JAMA Insights: Numeric risk comparisons anchored in patient context may improve shared decision-making and help patients interpret clinical choices.
https://ja.ma/3N0Rjao
Heat-related EMS activations increased 65% from 2019 to 2024, with the fastest increases among middle-aged adults, lower-middle–income communities, and those in the Mountain and West South Central US.
https://ja.ma/4aS8xzN
💬 Viewpoint: A proposed FDA “yellow book” could publicly aggregate medical device patent data, supporting oversight, research on device innovation, and detection of industry trends and device-related risks.
https://ja.ma/4ralIkn
"For everyone in medicine, not just medical students, our choice of specialty is just a single data point in what makes us who we are."
🖋️ Learn more in this essay by Emma Cooke, MD, MA.
https://ja.ma/4l82QkF
Platform clinical trials offer a flexible and efficient method to evaluate multiple treatments within a single protocol, streamlining operational and statistical processes compared with traditional designs.
JAMA Statistical Editor Roger Lewis, MD, PhD, and Steve Webb, MBBS, MPH, PhD, discuss the key features of platform trials, including adaptive structures, shared control groups, and domain-based randomization.
🎧 Listen now: https://ja.ma/3MNT0YG
Keratinocyte carcinomas are skin cancers that develop in the outer layer of the skin.
📄 Learn more about the risk factors, signs and symptoms, diagnosis, and treatment in this JAMA Patient Page: https://ja.ma/4ct8TxY
📊 JAMA Guide to Statistics and Methods: The Hochberg procedure is a multiplicity correction used in clinical trials to control the familywise error rate when comparing multiple end points.
Learn more: https://ja.ma/4ctfEjw
Current allocations under the Rural Health Transformation Program are inversely associated with rural mortality and hospital bed losses, indicating that funding may not reflect clinical need.
https://ja.ma/4uawhXg
In adults with major depressive disorder, the PETRUSHKA tool, which combines patient preferences and clinical predictors, was effective in personalizing antidepressant treatment and increased the likelihood of continuing treatment through 8 weeks.
https://ja.ma/4refCzI
This JAMA Patient Page describes hypothyroidism and its risk factors, signs and symptoms, diagnosis, screening, and treatment.
https://ja.ma/46zY9u4
Analysis of NHANES data from 2021 to 2023 found that 79.1% of US adults with hypertension had blood pressure above the 2025 American Heart Association/American College of Cardiology goal of <130/80 mm Hg.
https://ja.ma/40Pg8Jn
💬 Viewpoint: Removal of black box warnings for #menopausal hormone therapy reflects evidence that the risks and benefits vary by patient context, including hormone receptor status, formulation, and timing #postmenopause.
https://ja.ma/4booOwo
💡 JAMA Insights: Numeric risk comparisons anchored in patient context may improve shared decision-making and help patients interpret clinical choices.
https://ja.ma/4l9Ml7K
💬 Editorial: Personalized #antidepressant selection using clinical criteria and patient preferences may yield better outcomes than biomarker-driven approaches for #depression.
https://ja.ma/4aMox6p
📊 Research Summary: Among adults with major depressive disorder, use of a web-based decision-support tool reduced early #antidepressant discontinuation and improved symptoms compared with usual care.
https://ja.ma/4r1X1qd
In adults with major depressive disorder, the PETRUSHKA tool, which combines patient preferences and clinical predictors, was effective in personalizing antidepressant treatment and increased the likelihood of continuing treatment through 8 weeks.
https://ja.ma/4rGUQJU
📈 JAMA Clinical Guidelines Synopsis: The 2023 ACOG guideline recommends selective serotonin reuptake inhibitors (#SSRIs), used intermittently or continuously, as effective for managing affective symptoms of #premenstrual disorders.
https://ja.ma/47lQcbY
Newborn #nirsevimab immunization was associated with lower risks of RSV-related hospitalization and severe outcomes compared to maternal #RSVpreF vaccination.
https://ja.ma/4st1XG1
Researchers are untangling the mechanisms behind myocarditis after #COVID-19 mRNA vaccination, an extremely rare adverse effect.
https://ja.ma/4rHEIry
📌 Editor’s Choice from this week's issue of JAMA:
➡️ Risk-Based vs Annual #BreastCancer Screening,
➡️ Precision Immunotherapy for #Sepsis,
➡️ IgA Nephropathy Review, and more.
https://ja.ma/4b0h4iW
💬 Editorial by JAMA Senior Editor Derek Angus, MD, MPH: The ImmunoSep RCT demonstrates the feasibility of biomarker-guided treatment, while highlighting ongoing challenges in immune classification and broader clinical application.
https://ja.ma/4rMoQnC
RCT: Among patients with #sepsis, a precision immunotherapy strategy targeting macrophage activation-like syndrome and sepsis-induced immunoparalysis improved organ dysfunction by day 9 compared to placebo.
https://ja.ma/4aME863
IgA nephropathy is the most common cause of immune-mediated glomerular disease worldwide.
📄 This Review summarizes the pathophysiology, epidemiology, clinical presentation, diagnosis, treatment, and prognosis of primary IgA nephropathy in adults.
https://ja.ma/3NexRH9
💬 Editorial: Trialists found risk-based screening was as safe as annual screening for detecting advanced cancers but did not reduce breast biopsy rates.
https://ja.ma/4r7ER6u
The WISDOM study demonstrated that a risk-based approach successfully stratifies the population for breast cancer risk and is safe and acceptable to women.
https://ja.ma/3OHV1WR
Between 2000 and 2025, US donation after circulatory death (#DCD) increased from 2% to 49% of all deceased donors, driven by technologic advances in organ preservation.
https://ja.ma/3N9EzhA
💬 Perspective: As #AI increasingly guides diagnosis, documentation, and patient management, physicians’ roles are changing, prompting questions about sustaining empathy, accountability, and trust in algorithmic care.
https://ja.ma/4slgmnh
Chronic #diarrhea is defined by recurrent loose or watery stools, with or without increased stool frequency, fecal urgency, or fecal incontinence, that lasts for at least 4 weeks.
📄 Learn more about diagnosis and treatment strategies in this Review: https://ja.ma/4r5OVNi
Insufficient #sleep among US high school students increased from 2007 to 2023, with the rise driven largely by more adolescents reporting very short sleep durations of ≤5 hours per night.
https://ja.ma/4r9S1QG
💬 Perspective: As #AI increasingly guides diagnosis, documentation, and patient management, physicians’ roles are changing, prompting questions about sustaining empathy, accountability, and trust in algorithmic care.
https://ja.ma/4rLRjtX
William Chey, MD, of the University of Michigan joins JAMA Deputy Editor Mary M. McDermott, MD, to discuss strategies for diagnosis and treatment of chronic, noninfectious diarrhea. https://ja.ma/4aLUV7K