From 2015 to 2024, the number of early-stage drug development programs worldwide increased by more than 80%, with pronounced growth in China and a relative decline in the US and other high-income countries.
https://ja.ma/4s3JYVH
📍 #ACC26 attendees, don’t miss the JAMA Late‑Breaking Clinical Trials II session:
📅 Mar 28 | 3:45–4:45 PM CT
📍 Main Tent, Great Hall
Chaired by JAMA Executive Editor Greg Curfman, MD.
The Medicare #Oncology Care Model (OCM) was associated with modest reductions in Medicare payments for beneficiaries receiving #chemotherapy for cancer; however, overall program costs exceeded these spending reductions.
https://ja.ma/4s0gatg
Pertussis, or #WhoopingCough, is a common cause of severe and prolonged cough in adults in the US.
💡 Learn more about the epidemiology, transmission, and risk factors for pertussis in this JAMA Insights: https://ja.ma/4lVnR2z
📍 At #ACC26? Join the JAMA Late‑Breaking Clinical Trials II session:
📅 Sat, Mar 28 | 3:45–4:45 PM CT
📍 Main Tent, Great Hall
Chaired by JAMA Executive Editor Greg Curfman, MD
💬 Viewpoint: The ACCESS model by the Centers for Medicare & Medicaid Services will link #Medicare payments to patient outcomes in chronic disease, supporting digital health tools and team-based care over 10 years.
https://ja.ma/40ZKo4x
Med News: New lipid guidelines from @ACCinTouch and @American_Heart adopt earlier screening and intervention, a new risk calculator, updated risk categories, LDL-C targets, one-time universal Lp(a) testing, and other reworkings.
Find out more: https://ja.ma/47nU6Bp
Med News: Heart attacks in younger women are often underdiagnosed or misattributed. A recent statement from @American_Heart highlights this “clinical blind spot,” calling for improved recognition and care for premenopausal women. https://ja.ma/4sPKgRD
In multiorgan metastatic #ColorectalCancer, tumor debulking plus first-line palliative chemotherapy did not improve overall or progression-free survival compared with #chemotherapy alone, and was associated with more serious adverse events.
📽️ Watch the video and read the full article: https://ja.ma/47tAb3X
📊 JAMA Clinical Guidelines Synopsis: The 2026 #PediatricSepsis guidelines by SCCM and ESICM recommend immediate antimicrobial therapy for suspected septic shock and timely blood lactate measurement for all children with sepsis.
https://ja.ma/4bCX8nO
📊 JAMA Clinical Guidelines Synopsis: The newly released Surviving #Sepsis Campaign guidelines from ESICM and SCCM endorse early broad-spectrum antibiotics, rapid fluid resuscitation, and deescalation strategies for adults with sepsis or septic shock.
https://ja.ma/4uPXizX
Med News: #AI tools are changing how patients access health info.
From explaining medical terms to proving postoperative instructions to digitizing informed consent, experts explore how these technologies may serve as “clinician extenders.”
https://ja.ma/4swWwpH
💬 Perspective: Advanced organ preservation techniques have facilitated the increased use of organs from donors after circulatory death (#DCD), improving outcomes and increasing access for more patients.
https://ja.ma/4bxnwzu
💬 Editor's Note by Véronique Kiermer, PhD, Chief Scientific Officer of @PLOS, Kirsten Bibbins-Domingo, PhD, MD, MAS, Editor in Chief of @JAMA_current and @JAMANetwork, and Magdalena Skipper, PhD, Editor in Chief of @Nature:
Responsible research authorship is anchored in credit, accountability, and transparency. Institutions and journals can provide stronger guidance and must work together to maintain integrity in authorship decisions.
https://ja.ma/4rV9fkQ
John Torous, MD, MBI, joins JAMA+ AI Associate Editor Yulin Hswen, ScD, to discuss risks, data protections, and the clinical safeguards required to ensure responsible use.
https://ja.ma/4taQ4ou
#Stillbirth involves the death of a fetus about halfway through pregnancy or later or with a birth weight of at least 350 g.
📄 This JAMA Patient Page describes the causes, risk factors, and methods for evaluating stillbirth before and after it occurs. https://ja.ma/4bBHFV2
R to @JAMA_current: 💬 Editorial: Geographic shifts in pharmaceutical innovation require coordinated regulatory strategies to ensure global patient access and minimize supply chain vulnerabilities.
https://ja.ma/4bM3Arp
From 2015 to 2024, the number of early-stage drug development programs worldwide increased by more than 80%, with pronounced growth in China and a relative decline in the US and other high-income countries. 🧵
https://ja.ma/4rULaL2
📊 JAMA Clinical Guidelines Synopsis: The 2026 #PediatricSepsis guidelines by SCCM and ESICM recommend immediate antimicrobial therapy for suspected septic shock and timely blood lactate measurement for all children with sepsis.
https://ja.ma/4vbuUIL
📊 JAMA Clinical Guidelines Synopsis: The newly released Surviving #Sepsis Campaign guidelines from ESICM and SCCM endorse early broad-spectrum antibiotics, rapid fluid resuscitation, and deescalation strategies for adults with sepsis or septic shock.
https://ja.ma/4bN5R5x
Kirsten Bibbins-Domingo, PhD, MD, MAS, Editor in Chief of JAMA and the JAMA Network, was recognized among 12 trailblazing women in health, medicine, and science by @aspenideas: Health.
Her work in epidemiology and biostatistics, with a focus on health equity and advancing science communication, was highlighted during a panel on rebuilding trust in health and medicine.
Read more about her recognition and the other honorees at Aspen Ideas: Health. https://ja.ma/4lSdPzb
In this episode of JAMA+ AI Conversations, JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH, speaks with David Wu, MD, PhD, and Adam Rodman, MD, MPH, about the clinical risks of large language models (LLMs). https://ja.ma/4swbahb
💬 Viewpoint: Routine exclusion of pregnant individuals from RCTs has resulted in gaps in drug safety data, which can lead to unrecognized risks, inappropriate medication avoidance, or delayed guideline recommendations. https://ja.ma/40ReNSA
💬 Viewpoint: Rare genetic diseases collectively place a major burden on children, and pediatric care must be redesigned to provide earlier genomic diagnosis, coordinated management, and equitable access to emerging therapies.
https://ja.ma/3PXwltS
R to @JAMA_current: 💬 Editorial: The #Oncology Care Model achieved episode savings largely through supportive care medication changes, but net losses and limited impact on hospital use shaped the successor model.
https://ja.ma/4lNpzmB
The Medicare #Oncology Care Model (OCM) was associated with modest reductions in Medicare payments for beneficiaries receiving #chemotherapy for cancer; however, overall program costs exceeded these spending reductions. 🧵
https://ja.ma/4lRgGZc
Between 2000 and 2025, US donation after circulatory death (#DCD) increased from 2% to 49% of all deceased donors, driven by technologic advances in organ preservation.
https://ja.ma/4tc6tsS
Direct-acting antiviral prescriptions for #HepatitisC peaked in 2015, declined steadily, and shifted toward younger patients, Medicaid coverage, and rural counties, while specialist prescribing decreased.
https://ja.ma/4sysuSL
Among patients with idiopathic pulmonary fibrosis and chronic cough, nalbuphine ER achieved dose-dependent reductions in cough and improved symptom scores, with acceptable tolerability.
https://ja.ma/4uQbY1K
Med News: Low-carb or low-fat? For heart health, it may not matter.
New research finds food quality is what really counts.
https://ja.ma/3NWVTa0
📌 Editor’s Choice from this week's issue of JAMA:
➡️ #Antibiotic Therapy for Uncomplicated Acute #Appendicitis,
➡️ Electronic Health Record Intervention and Deprescribing for Older Adults,
➡️ Type 1 #Diabetes, and more.
https://ja.ma/4rWaa4x
Type 1 #diabetes occurs when the immune system destroys insulin-producing cells in the pancreas, leading to high blood glucose levels.
📄 Learn more in this JAMA Patient Page: https://ja.ma/3Ptl8Bm
📊 Research Summary: Behavioral science–informed EHR notifications increased deprescribing of potentially inappropriate medications in older adults, with precommitment and boostering prompts outperforming usual care.
https://ja.ma/4buoWL7
Among older adults receiving care in an academic health system, behavioral science–informed electronic health record interventions increased deprescribing or tapering of potentially inappropriate medications compared with usual care.
https://ja.ma/41nKHWX
#Type1Diabetes affects approximately 2 million people in the US and 8.4 million people worldwide.
Learn more about the diagnosis and treatment of type 1 diabetes in this JAMA Review.
https://ja.ma/4dMYDB8
💬 Editorial: Among adults with acute uncomplicated #appendicitis, findings from the APPAC trial indicate that antibiotic therapy remains a safe and feasible alternative to appendectomy; the decision "to cut or to keep" should be individualized.
https://ja.ma/3PvDstp
In adults with uncomplicated #appendicitis, 44% treated with antibiotics required appendectomy within 10 years, but complication rates were lower and quality of life similar to surgery.
https://ja.ma/3NU446Z
💬 Perspective: FDA removal of most black box warnings for #menopausal #HormoneTherapy enables individualized menopause symptom management; #estrogen-only therapy retains a warning for #endometrial cancer risk in women with a uterus.
https://ja.ma/4d5QkQJ
📊 JAMA Clinical Guidelines Synopsis: The 2025 ACC/AHA guideline recommends home and office #BloodPressure monitoring to confirm diagnosis and titrate medications, with a target blood pressure of <130/80 mm Hg for most adults.
https://ja.ma/4brFe7t
#ResistantHypertension affects approximately 10% of patients treated for #hypertension and is associated with increased #cardiovascular mortality compared with controlled blood pressure.
📄 Learn more in this Review: https://ja.ma/47kA8aG