Consilium publication out today! Check ⬇️
It may be that failure to count competitors stampeding towards your de-risked target is now the single biggest reason drug R&D programs fail in Phase 2 & 3.
"Commercial" termination overtakes "efficacy" circa 2019: https://www.nature.com/articles/d41573-025-00208-6
Recent oncology example (TIGIT herding): https://bmjoncology.bmj.com/content/5/1/e001037
This week's blog is a "spirited" conversation just in time for the holidays! 🎄
To read more, check out the blog here: https://healthontrial.substack.com/p/holiday-spirits-a-favorite-seasonal
💊 Oncology drugs have a shockingly low approval rate.
That’s not innovation — it’s waste.
🎓 Watch our full seminar: "The Waste in Futile Oncology Drug Development" on Youtube
What happened when public record requests were filed for correspondence between universities & journals?
Science isn’t failing, it’s correcting. Just far too slowly.
🎓 Watch the full seminar: "Why Retractions Are on the Rise" on our Youtube
If drug discovery is a desert, predictive validity is the compass.
Jack Scannell explains why so many promising lab results never reach patients: Bad models send science in the wrong direction.
Watch our full seminar: "Predictive Validity in Drug Discovery" on Youtube
This week the Consilium Chameleon experiences the healthcare system in Sweden - a land of islands, mythical creatures and pharmaceutical minimalism...
To read more, check out the latest blog here: https://healthontrial.substack.com/p/swedish-healthcare-where-everything?r=yinai&utm_campaign=post&utm_medium=web&triedRedirect=true
What if science got it wrong, and no one was allowed to say so?
Progress begins when someone dares to ask: What if we’re wrong?
Watch our full seminar: "Pathological Consensus" on Youtube
"The mortality rate from cancer worldwide is projected to rise in the next decade and that in Europe will equal almost that in the United States" - John Hickmann
Did Pharma Invent Your Disease? 💊
What if the “condition” you’ve been told you have… was actually created in a marketing office?
At Consilium Scientific, we stay independent to expose these tactics and push for healthcare that starts with patients, not profit.
✈️ Would you fly if 47% of flights weren’t tracked?
Then why do we accept that 47% of clinical trials disappear?
It’s time for accountability in science.
🎓 Watch our full seminar: "What’s Wrong with Clinical Trial Registries" on Youtube @ConsiliumScientific
Science isn’t broken, it’s correcting.
But flawed studies are still making it to print and shaping real-world decisions before they’re caught.
What do you think this says about the state of science?
Watch Ivan Oransky's full seminar on Youtube
Alzheimer’s Research: Chasing the Wrong Target? 🧠
For decades, research funding and headlines have revolved around one theory; that amyloid plaques are the root cause.
Meanwhile, new ideas are emerging:
✨ tau protein, inflammation, vascular, and lifestyle pathways.
🃏 What does poker have to do with clinical trials?
Prof. Frank Harrell: “The judgment of the poker player's skill is based on the same way we should be judging a clinical trial.”
🎓 From our seminar: "Modernising Clinical Trial Design and Analysis." Watch in full on Youtube
📢 LIVE today at 5PM GMT Join us for “The Role of Clinical Judgement in Psychiatry” with Giovanni Fava, MD. How much of psychiatry should rely on data, and how much on human judgement?
📷 Watch live on Youtube: https://www.youtube.com/channel/UCllf8tJ8IWMRyulOSm3wRSg
#Psychiatry #ConsiliumScientific
Absolutely this is the most important role for the pubic in science. Prevent the emergence of @NIH funded “Science Monopolies” comprising central control by a field of science by its leadership.
Watch this brief @consiliumsci video which explains the history of science monopoly in critical care.
https://youtu.be/BTgEU07FI9o
📽️ New video out now!
If you missed yesterday's seminar, The Role of Behavioural Science in Eliminating Cervical Cancer by Jo Waller, it is now available on our YouTube channel!
Watch here: https://www.youtube.com/watch?v=-ipTlUyZwOo&t=12s
Don't forget to join us tomorrow for a free online seminar with Jo Waller, where we'll explore the role that vaccinations and screening play in eliminating cervical cancer!
Find out more here 👇
🎙️ Join us this Thursday for our upcoming free seminar, Vaccination and screening: the role of behavioural science in eliminating cervical cancer
Find out more Jo here: https://consilium-scientific.org/component/content/article/115-speakers-25/708-jo-waller-phd?Itemid=437
📅 Thursday, 22nd May
🕔 5pm London Time
🎟️ Sign up here: https://www.eventbrite.com/e/1360554016689?aff=oddtdtcreator