From Breakthrough to Breakdown. When Immunity Loses Its Focus https://open.substack.com/pub/voiceforscienceandsolidarity/p/from-breakthrough-to-breakdown-when?r=y46t6&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
🇩🇪 Übersetzung
Vom Durchbruch zum Zusammenbruch. Wenn die Immunität ihren Fokus verliert https://open.substack.com/pub/voiceforscienceandsolidarity/p/from-breakthrough-to-breakdown-when?r=y46t6&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
Why the current ‘calm’ in SARS-CoV-2 evolution is an illusion of stability (‘endemicity’) and actually signals growing instability https://open.substack.com/pub/voiceforscienceandsolidarity/p/why-the-current-calm-in-sars-cov?r=y46t6&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
🇩🇪 Übersetzung
Warum die derzeitige „Ruhe“ in der SARS-CoV-2-Entwicklung eine Illusion von Stabilität („Endemizität“) ist und tatsächlich wachsende Instabilität signalisiert https://open.substack.com/pub/voiceforscienceandsolidarity/p/why-the-current-calm-in-sars-cov?r=y46t6&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
For those fed up with the endless, lowbrow squabbling between pro- and anti-vax roosters, here is a simplified version of my previous Substack article (https://voiceforscienceandsolidarity.substack.com/p/the-vaccine-debate-when-ideology), slightly extended by a few additional comments. Hopefully, it offers some genuine insight and encourages a more constructive search for ways to achieve population-level immune protection without causing harm. For anyone willing to understand it, this may help cut through the absurd polarization, hardly worthy of science, and the primitive animosities it keeps fueling within an already divided scientific community. And as if the spectacle were not already theatrical enough, an increasing number of influential figures-often armed with strong opinions but limited immunological literacy-have now entered the arena, adding fuel to the fire of polarization and turning what should be a biological discussion into a political spectacle. Seriously, do they think this is going to add any value to solving public health challenges?
The Vaccine Debate: When Both Sides Talk Past Each Other https://open.substack.com/pub/voiceforscienceandsolidarity/p/the-vaccine-debate-when-both-sides?r=y46t6&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
🇩🇪 Übersetzung
Für diejenigen, die genug von dem endlosen, bescheidenen Streit zwischen Impfbefürwortern und -gegnern haben, gibt es hier eine vereinfachte Version meines vorherigen Substack-Artikels (https://voiceforscienceandsolidarity.substack.com/p/the-vaccine-debate-when-ideology), leicht erweitert um ein paar zusätzliche Kommentare. Hoffentlich bietet es einige echte Erkenntnisse und regt zu einer konstruktiveren Suche nach Möglichkeiten an, einen Immunschutz auf Bevölkerungsebene zu erreichen, ohne Schaden anzurichten. Für jeden, der bereit ist, es zu verstehen, kann dies dazu beitragen, die absurde Polarisierung zu durchbrechen, die der Wissenschaft kaum würdig ist, und die primitiven Feindseligkeiten, die sie innerhalb einer bereits gespaltenen wissenschaftlichen Gemeinschaft immer wieder schürt. Und als ob das Spektakel nicht schon theatralisch genug wäre, betraten nun immer mehr einflussreiche Persönlichkeiten – oft mit starken Meinungen, aber begrenzten immunologischen Kenntnissen – die Arena, heizten das Feuer der Polarisierung an und verwandelten die eigentlich biologische Diskussion in ein politisches Spektakel. Im Ernst: Glauben sie, dass dies einen Mehrwert für die Lösung der Herausforderungen im Bereich der öffentlichen Gesundheit bringen wird?
Die Impfdebatte: Wenn beide Seiten aneinander vorbeireden https://open.substack.com/pub/voiceforscienceandsolidarity/p/the-vaccine-debate-when-both-sides?r=y46t6&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
The Vaccine Debate: When Ideology Replaces Immunology. https://open.substack.com/pub/voiceforscienceandsolidarity/p/the-vaccine-debate-when-ideology?r=y46t6&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
🇩🇪 Übersetzung
Die Impfdebatte: Wenn Ideologie die Immunologie ersetzt. https://open.substack.com/pub/voiceforscienceandsolidarity/p/the-vaccine-debate-when-ideology?r=y46t6&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
I'm invited to the PanaCeHa congress in Glattfelden (near Zurich) next weekend. I'd like to take the opportunity to visit some friends in Switzerland with my partner during the week of March 16.
Maybe a few folks reading my tweets live in Switzerland. Could be cool to meet up IRL there. Nothing beats face-to-face over social media! We're traveling in a fully equipped camper, so we're quite flexible. Perhaps we could arrange a quick chat, even though I realize weekdays might not be ideal for most of you. Feel free to contact me by email (geert.vandenbossche@live.be) if you think it's a good idea (English-, German-, French-speaking, vaccinated or non-vaccinated-no preference!). Warm regards, Geert
🇩🇪 Übersetzung
Ich bin nächstes Wochenende zum PanaCeHa-Kongress in Glattfelden (bei Zürich) eingeladen. Ich möchte die Gelegenheit nutzen, in der Woche vom 16. März mit meinem Partner einige Freunde in der Schweiz zu besuchen.
Vielleicht leben ein paar Leute, die meine Tweets lesen, in der Schweiz. Es könnte cool sein, sich dort persönlich zu treffen. Es gibt nichts Besseres als ein persönliches Gespräch über soziale Medien! Wir reisen in einem voll ausgestatteten Wohnmobil und sind daher recht flexibel. Vielleicht könnten wir ein kurzes Gespräch vereinbaren, auch wenn mir klar ist, dass Wochentage für die meisten von Ihnen möglicherweise nicht ideal sind. Kontaktieren Sie mich gerne per E-Mail (geert.vandenbossche@live.be), wenn Sie denken, dass es eine gute Idee ist (Englisch, Deutsch, Französisch sprechend, geimpft oder nicht geimpft – egal!). Herzliche Grüße, Geert
Wanneer macht experimenteert met de mensheid https://open.substack.com/pub/voiceforscienceandsolidarity/p/wanneer-macht-experimenteert-met?r=y46t6&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
When Power Experiments With Humanity https://open.substack.com/pub/voiceforscienceandsolidarity/p/when-power-experiments-with-humanity?r=y46t6&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
🇩🇪 Übersetzung
Wenn Macht mit der Menschheit experimentiert https://open.substack.com/pub/voiceforscienceandsolidarity/p/when-power-experiments-with-humanity?r=y46t6&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
@GVDBossche
@Honest_Medicine
RT
von @GVDBossche 05.03 16:28
Mayo Clinic-Trained Pathologist & Leading Healthcare Reform Advocate Dr. Ryan Cole Named as Head of Medical & Scientific Affairs at the Independent Medical Alliance
Dr. Cole helped ignite a national reckoning over censorship of physicians and now takes on a senior leadership role as the nation’s largest coalition of independent physicians continues expanding its reach into healthcare reform.
FULL STATEMENT: WASHINGTON, D.C. — The Independent Medical Alliance (IMA), a national coalition representing more than 12,000 independent physicians and clinicians, today announced the appointment of Dr. Ryan Cole (@DoctorCole) as its new Head of Medical & Scientific Affairs. The senior leadership role positions Dr. Cole as one of the nation’s foremost advocates for promoting the freedom of doctors to practice medicine guided by science and their patients, not censorship or medical industry control.
“Dr. Cole represents the very best of independent medicine. He is a physician who follows the data wherever it leads, even when it means standing firm against the medical status quo,” said Dr. Joseph Varon (@joevaron), IMA President and Chief Medical Officer. “Dr. Cole was among the first physicians in America to sound the alarm about COVID-19 vaccines causing myocarditis and other serious cardiac complications. He stood firm when others refused to acknowledge the data. We are proud to have him step into this leadership role.”
About the New Leadership Position
In his new role, Dr. Cole will provide strategic leadership over IMA’s medical education, scientific engagement, evidence interpretation, and policy translation efforts. He will review and refine IMA’s medical strategy, guide scientific communication initiatives, collaborate on research development, and serve as a principal medical and scientific spokesperson for the Alliance. As a member of the executive team, he will also ensure that IMA’s external-facing materials reflect the highest standards of scientific rigor and clinical accuracy.
“Medicine must return to science grounded in real-world clinical data and the sacred doctor-patient relationship,” said Dr. Cole. “IMA brings together thousands of independent clinicians who treat patients every single day. In this new role, I look forward to helping translate frontline clinical evidence into responsible education, meaningful research collaboration, and policy solutions that improve patient outcomes and restore the trust in healthcare.”
A Growing National Movement
Dr. Cole’s appointment reflects the IMA’s continued growth and expanding influence with policymakers, researchers, and institutions seeking independent medical expertise at a time when the nation is re-examining how it handled the pandemic.
“An increasing number of IMA’s independent physicians are being called upon to help reform federal health policy from the inside,” said Dr. Varon. “Dr. Cole’s appointment formalizes what many in medicine and government already recognize, his role as a trusted scientific voice helping bridge rigorous clinical medicine with responsible healthcare reform.”
About Dr. Ryan Cole
Dr. Cole is a Mayo Clinic–trained, board-certified anatomic and clinical pathologist with subspecialty expertise in dermatopathology and molecular diagnostics. Over a career spanning more than two decades, he has reviewed hundreds of thousands of tissue and blood samples through Cole Diagnostics, the independent laboratory he founded in Boise, Idaho, in 2004. He is recognized for identifying emerging biological and immune-system patterns before they surface in broader population data.
An IMA Senior Fellow since the program’s inception, Dr. Cole has testified before federal, state, and international legislative bodies on matters of vaccine safety, medical freedom, and pandemic policy. He was a leading voice in the effort to pass Idaho’s landmark Medical Freedom Act, which Governor Brad Little signed into law in April 2025.
🇩🇪 Übersetzung
RT von @GVDBossche: Dr. Ryan Cole, in der Mayo-Klinik ausgebildeter Pathologe und führender Befürworter einer Gesundheitsreform, wird zum Leiter für medizinische und wissenschaftliche Angelegenheiten bei der Independent Medical Alliance ernannt
Dr. Cole hat dazu beigetragen, eine landesweite Auseinandersetzung über die Zensur von Ärzten auszulösen, und übernimmt nun eine Führungsrolle, während die landesweit größte Koalition unabhängiger Ärzte ihre Reichweite im Bereich der Gesundheitsreform weiter ausbaut.
VOLLSTÄNDIGE ERKLÄRUNG: WASHINGTON, D.C. – Die Independent Medical Alliance (IMA), eine nationale Koalition, die mehr als 12.000 unabhängige Ärzte und Kliniker vertritt, gab heute die Ernennung von Dr. Ryan Cole (@DoctorCole) zum neuen Leiter für medizinische und wissenschaftliche Angelegenheiten bekannt. Durch seine Führungsrolle gilt Dr. Cole als einer der führenden Befürworter des Landes für die Förderung der Freiheit von Ärzten, ihre Medizin unter der Führung der Wissenschaft und ihrer Patienten zu praktizieren, und nicht von Zensur oder der Kontrolle der medizinischen Industrie.
„Dr. Cole repräsentiert das Beste der unabhängigen Medizin. Er ist ein Arzt, der den Daten folgt, wohin sie auch führen, auch wenn das bedeutet, sich entschieden gegen den medizinischen Status quo zu stellen“, sagte Dr. Joseph Varon (@joevaron), Präsident und Chief Medical Officer von IMA. „Dr. Cole gehörte zu den ersten Ärzten in Amerika, die Alarm schlugen, weil COVID-19-Impfstoffe Myokarditis und andere schwere Herzkomplikationen verursachten. Er blieb standhaft, als andere sich weigerten, die Daten anzuerkennen. Wir sind stolz, dass er diese Führungsrolle übernimmt.“
Über die neue Führungsposition
In seiner neuen Rolle wird Dr. Cole die strategische Leitung der medizinischen Ausbildung, des wissenschaftlichen Engagements, der Interpretation von Erkenntnissen und der Umsetzung von Richtlinien bei IMA übernehmen. Er wird die medizinische Strategie von IMA überprüfen und verfeinern, wissenschaftliche Kommunikationsinitiativen leiten, an der Forschungsentwicklung mitarbeiten und als Hauptsprecher für Medizin und Wissenschaft der Allianz fungieren. Als Mitglied des Führungsteams wird er außerdem dafür sorgen, dass die nach außen gerichteten Materialien von IMA den höchsten Standards wissenschaftlicher Genauigkeit und klinischer Genauigkeit entsprechen.
„Die Medizin muss zur Wissenschaft zurückkehren, die auf realen klinischen Daten und der heiligen Arzt-Patienten-Beziehung basiert“, sagte Dr. Cole. „IMA bringt Tausende von unabhängigen Klinikern zusammen, die jeden Tag Patienten behandeln. In dieser neuen Rolle freue ich mich darauf, dabei zu helfen, klinische Erkenntnisse an vorderster Front in verantwortungsvolle Aufklärung, sinnvolle Forschungszusammenarbeit und politische Lösungen umzusetzen, die die Patientenergebnisse verbessern und das Vertrauen in die Gesundheitsversorgung wiederherstellen.“
Eine wachsende nationale Bewegung
Die Ernennung von Dr. Cole spiegelt das kontinuierliche Wachstum und den wachsenden Einfluss der IMA bei politischen Entscheidungsträgern, Forschern und Institutionen wider, die unabhängige medizinische Expertise suchen, zu einer Zeit, in der das Land seinen Umgang mit der Pandemie neu prüft.
„Immer mehr unabhängige Ärzte der IMA werden aufgefordert, von innen heraus bei der Reform der Bundesgesundheitspolitik mitzuhelfen“, sagte Dr. Varon. „Dr. Coles Ernennung formalisiert, was viele in der Medizin und in der Regierung bereits erkennen: seine Rolle als vertrauenswürdige wissenschaftliche Stimme, die dabei hilft, eine Brücke zwischen strenger klinischer Medizin und verantwortungsvoller Gesundheitsreform zu schlagen.“
Über Dr. Ryan Cole
Dr. Cole ist ein an der Mayo Clinic ausgebildeter, staatlich geprüfter anatomischer und klinischer Pathologe mit Spezialkenntnissen in Dermatopathologie und Molekulardiagnostik. Im Laufe seiner mehr als zwei Jahrzehnte dauernden Karriere hat er bei Cole Diagnostics, dem unabhängigen Labor, das er 2004 in Boise, Idaho, gegründet hat, Hunderttausende Gewebe- und Blutproben untersucht. Er ist dafür bekannt, neu auftretende biologische Muster und Muster des Immunsystems zu identifizieren, bevor sie in breiteren Bevölkerungsdaten auftauchen.
Dr. Cole ist seit Beginn des Programms IMA Senior Fellow und hat vor gesetzgebenden Körperschaften auf Bundes-, Landes- und internationaler Ebene zu Fragen der Impfstoffsicherheit, der medizinischen Freiheit und der Pandemiepolitik ausgesagt. Er war eine führende Stimme bei den Bemühungen um die Verabschiedung des wegweisenden Medical Freedom Act von Idaho, den Gouverneur Brad Little im April 2025 in Kraft setzte.
Less Drama, More Guests! https://open.substack.com/pub/voiceforscienceandsolidarity/p/less-drama-more-guests?r=y46t6&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
I am a non-religious vaccinologist! https://open.substack.com/pub/voiceforscienceandsolidarity/p/i-am-a-non-religious-vaccinologist?r=y46t6&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
🇬🇧 Translation
I am a non-religious vaccinologist! https://open.substack.com/pub/voiceforscienceandsolidarity/p/i-am-a-non-religious-vaccinologist?r=y46t6&utm campaign=post&utm medium=web&showWelcomeOnShare=true
This is how you fuel people’s aversion to vaccines! https://open.substack.com/pub/voiceforscienceandsolidarity/p/this-is-how-you-fuel-peoples-aversion?r=y46t6&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
All Wheels Turning, No Ground Gained: Metastability Is Not Stability! https://open.substack.com/pub/voiceforscienceandsolidarity/p/all-wheels-turning-no-ground-gained?r=y46t6&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
Dr. Rennebohm's New Book: Sowing Seeds of Social Beauty: the Untold Story of the Children's Hospital Public Economy Model (CHPEM). https://open.substack.com/pub/voiceforscienceandsolidarity/p/dr-rennebohms-new-book-sowing-seeds?r=y46t6&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
What you present here is not a rebuttal of my work; it is a rejection of modern virology!
1) ‘There is no antigenic drift with coronaviruses.’ Wrong. Coronaviruses-including SC-2-do evolve antigenically under immune selection. The presence of an RNA proofreading exonuclease lowers the mutation rate but does not prevent mutation, selection, or antigenic change. This is evidenced by millions of publicly available SC-2 genomes documenting continuous diversification, convergent evolution, immune escape, and lineage turnover. If antigenic evolution did not occur, Omicron-era reinfections and immune escape would be biologically impossible!
2) ‘Immunity is lifelong; people can’t be infected twice.’ Wrong. Endemic human coronaviruses reinfect individuals repeatedly, often within months to a year. SC-2 reinfections are widespread and well documented across ages and immune backgrounds. Lifelong sterilizing immunity is not the norm for respiratory viruses.
3) ‘Coronaviruses do not recombine.’ Wrong. Coronaviruses are among the most recombination-prone RNA viruses due to template switching during replication. SC-2 recombinants (e.g., XE, XBB, JN.1 derivatives) are genetically resolved, phylogenetically mapped, and epidemiologically tracked. Recombination is not speculative; it is observed!
4) ‘Herd immunity is 67%.’
Wrong.There is no fixed herd-immunity threshold independent of transmission dynamics, immune durability, immune escape or population structure. For SC-2, especially with immune-escape variants, classical herd immunity has not been achievable. This is basic epidemiology!
5) ‘Spillover to animals resets viral adaptation.’ Wrong. It does not. Spillover creates additional reservoirs and opportunities for diversification; it does not erase adaptation accumulated in humans. Re-introduction from animals can even return viruses with new adaptive features. Animal reservoirs complicate control; they do not ‘solve’ immune pressure in the dominant host species!
6) ‘Delta was influenza; influenza mutates without a host.’
Both statements are wrong! Delta was a SC-2 variant. No virus mutates ‘without a host.’ Viral replication, and therefore mutation, requires host cells. Influenza’s antigenic dynamics differ in mechanism, not in the existence of evolution.
7) ‘Where are the genomes?’
They are publicly available in GISAID and other repositories-numbering in the millions-used daily by researchers worldwide. Denying their existence is not skepticism; it is refusal to engage with data or complete ignorance about their existence!
Last, my work does not claim that SC-2 behaves like influenza, nor that proofreading is irrelevant. It addresses population-level immune pressure on transmissibility, phenotypic constraint and the conditions under which incremental amino-acid change becomes insufficient-favoring qualitative shifts (e.g., glycosylation-mediated immune escape that decouples spread from antigen presentation). None of the claims above engage that framework; they deny the prerequisites of evolutionary biology itself!
In short: dismissing mutation, recombination, reinfection, immune selection and genomic surveillance does not refute my analysis. It abandons the biological foundations required to discuss viral evolution at all.
Please regard this as my final reply on this matter; I've have better things to do than focus on your naive barking.
No PH authority should intervene in a pandemic without understanding the mechanisms underlying the viral evolutionary dynamics, just as no MD should treat a sick patient without an accurate diagnosis https://open.substack.com/pub/voiceforscienceandsolidarity/p/no-ph-authority-should-intervene?r=y46t6&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
No matter how hard it is for me, I’ll try to stay calm. Although responding to comments built on such misconceptions is a poor use of time, I do so out of a sense of responsibility. Public discourse deserves protection from confidently delivered but scientifically illiterate claims that mislead readers under the guise of certainty based on alleged knowledge in the field. So, I hope your followers will read this too.
Your objection rests on a cascade of fundamental misunderstandings about virology and viral evolution.
First, antigenic drift, recombination, and selection are not exclusive to influenza. They are universal evolutionary mechanisms that apply to all replicating genetic systems, including coronaviruses (CoVs). While influenza lacks proofreading and therefore accumulates substitutions faster, SC-2 has demonstrated extensive antigenic drift in real time, documented by tons of sequenced genomes and thousands of peer-reviewed studies. Proofreading in viral replication means the polymerase corrects many copying errors, so the mutation rate becomes lower but not zero. Because some mutations still arise, natural selection continues to act on them, which allows viral antigenic evolution/ adaptation to proceed, just more slowly or constrained.
Second, the claim that CoVs do not recombine is simply false. CoVs are, in fact, among the most recombinogenic RNA viruses known!! Recombination is typically associated with CoV evolution and has been repeatedly demonstrated for SC-2. This is not controversial, it is simply textbook virology!
Third, your statement on herd immunity is totally contradicted by persistent (vaccine-breakthrough) reinfections, continuous variant turnover, immune escape and the absence of durable sterilizing immunity. Herd immunity requires stable transmission-blocking immunity, which none of the highly C-19-vaccinated populations has ever mounted against SC-2.
Fourth, the suggestion that SC-2 can simply ‘escape’ immune pressure by spilling into other mammals reflects yet another misunderstanding of evolutionary constraints. Spillover does not reset viral adaptation! Cross-species transmission of co-circulating immune escape variants from highly C-19-vaccinated populations would imposes highly severe fitness costs and extremely challenging host-specific adaptation; furthermore, it does not relieve immune pressure in the population in which the virus replicates most frequently and in the largest numbers. For SC-2, that has overwhelmingly been the human population, especially highly C-19-vaccinated populations, where repeated vaccine breakthrough (re-)infections occur. Evolution follows replication density or selection pressure intensity-not the kind of wishful ecological shortcuts you’re proposing. Consequently, human immunity-not animal immunity-defines the dominant evolutionary immune pressure on SC-2!
Fifth, the idea that SC-2 ‘runs out of options and disappears’ once a threshold is reached ignores basic evolutionary logic. When conventional mutational routes become constrained, selection favors qualitative shifts in phenotype, not extinction. This is precisely what my analysis addresses.
Last but not least, your attempt to dismiss viral mutation, drift, recombination and selection occurring during this ‘immune escape’ pandemic does not challenge my theory-it rejects modern molecular biology outright and constitutes a ridiculous denial of empirical reality.
Lay Summary on: "Same feed, different fleas: why BA.3.2 looks different across highly Covid-19-vaccinated countries without being benign!" https://open.substack.com/pub/voiceforscienceandsolidarity/p/lay-summary-on-same-feed-different?r=y46t6&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
Same feed, different fleas: why BA.3.2 looks different across highly Covid-19-vaccinated countries without being benign! https://open.substack.com/pub/voiceforscienceandsolidarity/p/same-feed-different-fleas-why-ba32?r=y46t6&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
For those who find it too challenging to read my recent Substack article (https://voiceforscienceandsolidarity.substack.com/publish/post/187208072), here follows a two-page lay summary: "Everyone knows a pus-filled abscess will eventually burst. However, nothing is more difficult than predicting exactly when it will burst..." https://open.substack.com/pub/voiceforscienceandsolidarity/p/lay-summary-on-recent-substack-article-311?r=y46t6&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
Everyone knows a pus-filled abscess will eventually burst. However, nothing is more difficult than predicting exactly when it will burst... https://open.substack.com/pub/voiceforscienceandsolidarity/p/everyone-knows-a-pus-filled-abscess?r=y46t6&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
@GVDBossche
@MaryBowdenMD
RT
von @GVDBossche 06.02 17:30
Please share, then sign. Help us get to 1 million signatures.
https://www.change.org/p/we-the-people-demand-a-moratorium-on-mrna-modrna-gene-therapy-technology?utm_medium=custom_url&utm_source=share_petition&recruited_by_id=f665b4c0-62fc-11e6-b026-7ddb9c922c8c
I am not sure I agree! The behavior of BA.3.2 is not consistent with endemic stabilization or ‘partial susceptibility,’ but with escalating immune constraint! A true endemic equilibrium would not require this extensive mutational effort (>50 mutations in S alone!). In highly C-19 vaccinated populations, susceptibility is dynamic, not compartmentalized, and true partial susceptibility would rapidly collapse into either a selective sweep or extinction of SARS-CoV-2, not just co-circulation! Instead, BA.3.2 shows slow or stagnating, but persistent expansion, extensive S remodeling, strong convergent evolution, and yet no decisive growth advantage-a typical evolutionary signature of constraint, not endemic stabilization! Such high mutational effort for marginal phenotypic gain indicates that further improvement via amino-acid substitution has become sterically and functionally limited under population-level immune pressure on transmissibility (exerted by highly C-19-vaccinated populations!). The resulting metastable plateau below dominance is therefore best interpreted as an evolutionary dead-end behavior, i.e., a hallmark of a system nearing the threshold to a phase transition, not an endemic equilibrium! In this context, stabilization does not reflect resolution but exhaustion of conventional evolutionary mutations, setting the stage for a dangerous qualitative phase transition rather than benign co-circulation: https://www.trialsitenews.com/a/plausibility-of-more-extended-o-glycosylation-as-last-resort-for-sars-cov-2-immune-escape-e1a08faf
Let's assume the NIH issued a similar statement about ‘all the high officials and scientists who pushed the world into mass vaccination, now swearing up and down that they never recommended vaccine mandates’. Would you then write a similar self-pitying epistle, trying to make people believe that mass vaccination in the midst of the pandemic using non-sterilizing vaccines was the best approach possible to solving a 'very complex health crisis'? Probably yes, because you were a fervent advocate of that C-19 vaccination program. Here you can't brush off a blunder of this magnitude as being based on 'uncertainty' and 'difficult decision-making'. It was well known that mass vaccination in the midst of a pandemic using non-sterilizing vaccines would inevitably drive collective immune selection pressure and lead to a fulminant increase in the prevalence of more infectious variants. I simply can't understand how a virologist can defend the public health merit of such a strategy, knowing that instead of generating herd immunity, it drives viral immune escape. Even though 'experts' like you and others may argue that vaccinees are still largely protected against acute C-19 disease, you should know better for the long term. Viral escape under population-level immune pressure is a serious threat now hanging like a sword of Damocles over the heads of highly C-19 vaccinated populations. And don't tell me it's not true just because it wasn't previously published in a peer-reviewed journal but only in TrialSiteNews (http://www.trialsitenews.com/a/plausibility-of-more-extended-o-glycosylation-as-last-resort-for-sars-cov-2-immune-escape-e1a08faf). The conclusion that the vaccine still protects against acute disease is the real 'oversimplification' you’re alluding to and remarkably shortsighted as it completely disregards the long-term consequences for public health. If you still consider it mere banal speculation, perhaps you can tell me how YOU think this pandemic will end and whether you truly believe the consequences of this absurd mass vaccination will just be ‘limited’ to some further crippling of the population. I know, I'm speaking harsh words, but it's only that language understood by those who dare to pretend they’re ‘standing up for public health’ and ‘busting their butts’, when in reality they declined an open scientific debate and instead ridiculed and gaslighted us because of our dissenting views. Declining debate with independent colleague scientists is an unforgivable mistake. This is exactly what polarized the world about the Covid crisis. So forget about rebuilding trust in the organizations you're so proud to work with. You claim to understand that the phenomenon of this pandemic is ‘complex’, but you're a member of the club that has utterly failed to grasp the complex consequences of this mass vaccination madness. Even when Omicron hit, the countless vaccine breakthrough infections in C-19 vaccinees that inevitably boosted their vaccinal immunity and thereby inevitably turned the pandemic into a self-perpetuating IMMUNE ESCAPE pandemic, didn't ring a bell. Even then, you guys kept recommending further vaccination. Let's be honest: none of you truly understood the evolutionary dynamics of this pandemic, and to this day, none of you has any clue where this is going. Such advisers, experts, and scientists are completely useless to society.
Very interesting: see my latest substack: https://voiceforscienceandsolidarity.substack.com/p/plausibility-of-more-extended-o-glycosylation
Enjoy the silence…. before the storm…
And indeed: some folks with poor cell-mediated adaptive immunity may need hospitalization since SC-2 is now primarily attacked by T cells, rather than Abs. However, nothing comparable to the kind of clinical outcome I am predicting with Hi-vi-cron.
Lay summary on recent Substack article: "A Pandemic Panic for Two Mutations, but None for Fifty!" https://open.substack.com/pub/voiceforscienceandsolidarity/p/lay-summary-on-recent-substack-article?r=y46t6&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
A Pandemic Panic for Two Mutations, but None for Fifty! https://open.substack.com/pub/voiceforscienceandsolidarity/p/a-pandemic-panic-for-two-mutations?r=y46t6&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
For those who find it too challenging to read my most recent findings on the impending evolution of the SARS-CoV-2 virus (https://www.trialsitenews.com/a/from-enhanced-infectiousness-to-enhanced-virulence-why-a-glycosylation-driven-shift-in-sars-cov-2-evolution-has-become-increasingly-likely-2cc974ed), here follows a four-page lay summary: https://open.substack.com/pub/voiceforscienceandsolidarity/p/lay-summary-on-plausibility-of-more?r=y46t6&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
For those who find it too time-consuming to read my most recent findings on the impending evolution of the SARS-CoV-2 virus (https://www.trialsitenews.com/a/plausibility-of-more-extended-o-glycosylation-as-last-resort-for-sars-cov-2-immune-escape-e1a08faf?utm_source=chatgpt.com), here follows a four-page scientific summary: https://open.substack.com/pub/voiceforscienceandsolidarity/p/scientific-summary-4-pp-on-plausibility?r=y46t6&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
Plausibility of more extended O-glycosylation as last resort for SARS-CoV-2 immune escape. https://open.substack.com/pub/voiceforscienceandsolidarity/p/plausibility-of-more-extended-o-glycosylation?r=y46t6&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
Note to readers: Some of my followers may raise their eyebrows at reading this article and think I'm schizophrenic for sharing such complex (and mostly incomprehensible 😒 ) analysis of the COVID-19 pandemic. However, my main goal is to thoroughly document my insights and the science behind it. That way, no so-called global health expert, authority, or anyone else who pushed the mass vaccination can ever claim the pandemic's disastrous outcome was totally unpredictable or unrelated to the mass vaccination program.
Even though I personally believe AI will eventually become a plague to humanity (probably sooner than we think), it's still in a constructive and positively impactful phase for now. I, therefore, recommend that anyone who gives me even a shred of credibility ask any AI tool to verify my theory, and even simplify and explain the message in my last article, and also my previous one (https://www.trialsitenews.com/a/from-enhanced-infectiousness-to-enhanced-virulence-why-a-glycosylation-driven-shift-in-sars-cov-2-evolution-has-become-increasingly-likely-2cc974ed) in plain language. That would add substantial value to this comprehensive analysis as it would credibly warn the widest possible audience about the impending HI-VI-CRON tsunami.
In the meantime, I can only advise all those primed by COVID vaccines to prophylactically start taking a safe and effective antiviral treatment at the very first sign of this tsunami (IMO, most clearly signaled by a sudden and sharp surge in hyperacute disease and mortality in one or more highly C-19-vaccinated regions) and to continue it until the tsunami has completely passed.
Lingenfelter treats the current SC-2 pandemic as if it were governed by historical, post-pandemic evolutionary rules, when in fact it is unfolding under conditions that have no precedent in human virology. Mass vaccination with a mismatched antigen during an active pandemic has radically altered the evolutionary landscape. No previous virus has encountered a situation in which millions (billions?) of hosts were simultaneously primed with the same ancestral antigen while the circulating virus was already antigenically divergent. Any analysis that extrapolates from historical global health data without accounting for this distortion is conceptually incomplete. Lingenfelter’s argument further ignores the large-scale recall dynamics of vaccine-breakthrough infections. Repeated VBTIs do not merely boost neutralizing Abs; they repeatedly recall broad, poorly neutralizing Ab repertoires and cytotoxic memory T cells, creating population-level immune pressure on viral transmissibility, not just on viral entry. This type of collective, recall-biased immune pressure has never occurred on a global scale and is not captured by standard evolutionary or epidemiological models. He also confuses inapparent/asymptomatic spread with benign evolution. The absence of worsening clinical signals during the expansion of new variants does not imply attenuation! Under strong population-level immune pressure on viral transmissibility, selection favors breadth rather than dominance, resulting in diversification into numerous cryptic, co-circulating variants whose expansion is diluted and therefore difficult to detect clinically. This is a hallmark of steric saturation, not stability or safety. The claim that glycosylation necessarily drives attenuation is biologically unsound. Glycosylation is not intrinsically ‘tolerogenic.’ In multiple viral systems-including HIV, Ebola, dengue, and coronaviruses-glycan remodeling has been shown to enhance virulence, facilitate lectin-mediated attachment, promote trans-infection, and enable cell-to-cell spread. Ignoring lectin biology while invoking glycosylation as a benign force is a serious omission! Crucially, Lingenfelter never addresses the dominant selective force now acting on SC-2: CTL-mediated immune pressure on transmission. Cytolytic memory T cells impose a binary constraint by rapidly aborting viral replication in infected cells. This pressure cannot be relieved by incremental antigenic drift! It can only be bypassed if viral spread becomes increasingly decoupled from MHC-dependent antigen presentation, for example through trans-infection and trans-fusion pathways. Glycosylation becomes relevant here not as a cause of attenuation, but as a mechanism that can enable such a phenotypic shift. Finally, Lingerfelter naively reverses the causal chain of viral evolution. The correct sequence is: Immune pressure → amino-acid remodeling of Spike → increasing steric instability → compensatory glycosylation → qualitative phenotype shift. Presenting glycosylation as the primary driver and amino-acid mutations as secondary adaptations has no mechanistic basis in protein evolution or immunovirology! Underlying all of this is a teleological bias-the assumption that viruses naturally evolve toward benignity and endemicity!! Evolution optimizes replication and survival, not host welfare. Endemicity is an epidemiological outcome, not an evolutionary goal, and it only emerges when herd immunity suppresses transmission without driving further escape-a condition that is demonstrably absent in highly C-19-vaccinated populations. Dismissing alternative evolutionary trajectories because they are uncomfortable or unprecedented is not scientific consensus-it is historical extrapolation in a system that has broken all historical assumptions. All Lingerfelter’s fantasy is based on self-directed study rather than any serious training in immunology, vaccinology, virology, or evolutionary biology. It is unclear to what extent his simplistic reasoning has been inspired by ‘divinity,’ the only field in which Lingerfelter holds a PhD.