Spiritualität ist eine von 26 empirisch identifizierten Sinnquellen. Die Forscherin Tatjana Schnell erklärt, wer darin Erfüllung findet und wie die Verbundenheit mit etwas Grösserem das Hier und Jetzt prägt. Der Sinnimpuls. https://www.nzz.ch/wissenschaft/spiritualitaet-im-alltag-wie-sie-das-leben-bereichert-ld.1920402?utm_campaign=mrf-twitter-NZZ&mrfcid=2026040369cc600115be38379d8b28da
ARTEMIS II AS SEEN BY THE OFFICIAL NASA CESSNA
THIS IS THE BEST LAUNCH VIDEO AND IT ISN'T CLOSE
Einmal mehr lassen Schweizer Behörden Sorgfältigkeit im Umgang mit wichtigen Datensätzen vermissen. Das kratzt am Selbstverständnis eines Landes, das sich auch über das Funktionieren definiert. https://www.nzz.ch/panorama/menschliches-fehlverhalten-appenzell-innerrhoden-gibt-einem-journalisten-aus-versehen-ueber-150-heikle-dokumente-ld.1932190?utm_campaign=mrf-twitter-NZZ&mrfcid=2026040369cc600115be38379d8b28d9
Die Artemis 2 ist unterwegs zum Mond. Die Nasa spricht von «gigantischen Schritten». Ein Blick hinter die Kulissen der Mission. https://www.nzz.ch/panorama/zehn-tage-in-einer-kapsel-so-gross-wie-ein-badzimmer-wer-sind-die-vier-artemis-astronauten-und-was-machen-sie-im-weltall-ld.1932189?utm_campaign=mrf-twitter-NZZ&mrfcid=2026040369cc600115be38379d8b28d8
From Tehran to the C-Suite: A Biotech CEO on AI, Drug Discovery, and the Me-Too Problem
Ali Mortazavi is not your typical biotech CEO. A computer scientist by training, former professional chess player, and veteran of financial markets, he invested in an RNAi company in 2012 — and then, by his own admission, made the crazy decision to become its CEO with zero background in biology, chemistry, or medicine.
What followed is a 14-year education in the brutal realities of drug development — and a front-row seat to the AI revolution now reshaping it. In this wide-ranging conversation, Mortazavi draws on his extraordinary personal story (fleeing revolutionary Iran as a child, arriving in London unable to speak English, rising through chess and finance) to offer a uniquely cross-disciplinary perspective on why biotech is stuck in a me-too loop, why the incentive system is the real bottleneck, and where AI is — and isn't — changing the game.
Subscribe to The Doctor's Lounge:Apple Podcasts | Spotify | YouTube | RSS
Follow the Show:X: @DrsLoungePod
Follow the Guest:X: @AAMortazavi
Co-hosts:@anish_koka | @drdanchoi | @dutchrojas | @sdixitmd | @drdigiorgio
Chapters
0:00 - Introduction & Ali's Background
1:07 - The Iranian Revolution at Nine Years Old
4:44 - Fleeing Iran, Arriving in London
6:38 - The Refugee Experience and Starting Over
7:49 - Computer Science in 1990
9:53 - Becoming a Professional Chess Player
11:06 - The Vishwanathan Anand Moment
13:17 - From Chess to Finance to Biotech CEO
14:44 - The Gleevec Illusion and the Reality of Drug Development
16:07 - Jay Bhattacharya, Reproducibility, and the PubMed Button
18:18 - LLMs as Scientific Compression Systems
20:15 - Why LLMs Give "The Average Answer" — The Co-Pilot Model
23:44 - Vibe Coding and the Explosion of Code
25:36 - AI Won't Replace 10x Coders — It Will Replace 90 of 100
26:16 - The GalNAC Case Study: 35 Years of Forgotten Innovation
31:10 - The Me-Too Algorithm and Biotech VC Incentives
34:40 - GLP-1s: Another 30 Years of Sitting Around
35:26 - The FDA, the XBI, and the Current Regulatory Landscape
40:43 - Can Politics Fix the Incentive System?
42:09 - Why Past Progress Happened Without AI
44:24 - Medical Ethics, Experimentation, and the Innovation Tradeoff
48:34 - Biotech Is Archaic: The Preclinical De-Risking Problem
50:05 - No Animal Model Actually Works
52:16 - Over-Regulation vs. Just Plain Hard
53:00 - The US Market as the Global Subsidy Engine
54:05 - China: Wake-Up Call, Not Innovator
56:25 - The London Market: "Don't Call It a Market"
58:52 - AI-Native Biotechs: Too Soon to Tell
59:36 - Where AI Works: Information. Where It Doesn't: Physics.
1:01:29 - Tangram Therapeutics and Libra OS
1:04:25 - The Future: SaaS Collapse, Medicine Returns to Fundamentals
1:07:36 - Closing: Hope, Broken Glass, and Early Adoption
A student-athlete turned in a 146-word essay about Rosa Parks — one paragraph, riddled with errors, no sources — and got an A-minus. That single paper helped expose the biggest academic fraud in NCAA history.
For 18 years, from 1993 to 2011, a department secretary named Deborah Crowder ran fake courses at the University of North Carolina. @UNC The classes never met. There was no syllabus and no professor.
Students turned in one paper per semester. Crowder admitted she never read them. She skimmed introductions and handed out A’s.
UNC’s academic counselors steered athletes into these courses each semester, specifying what grades each player needed. Athletes made up 47% of enrollments despite being just 4% of the student body.
Rashad McCants, a star on UNC’s 2005 championship team, told ESPN he made the Dean’s List without attending a single class. Ten of fifteen players on that title team were enrolled in paper courses.
When whistleblower Mary Willingham revealed that 60% of athletes read at a 4th-to-8th grade level, UNC attacked her publicly and fans sent death threats. She was forced to resign.
In October 2014, a 136-page investigation confirmed the scope: 188 fake classes, 3,100 students, 18 years of fraud.
And the punishment? In October 2017, the NCAA ruled there were no significant violations. Zero penalties. No vacated wins. No postseason bans.
@UNC calls themselves a bastion of academia. How incredibly pathetic.
Ein 32-jähriger Türke wehrte sich gegen den Vorwurf der Gehilfenschaft zu vorsätzlicher Tötung. Das Zürcher Obergericht hat ihn nun auf Veranlassung des Bundesgerichts davon freigesprochen. https://www.nzz.ch/zuerich/obergericht-entastet-tuerken-im-fall-jeton-g-vom-vorwurf-der-gehilfenschaft-ld.1932185?utm_campaign=mrf-twitter-NZZ&mrfcid=2026040369cc600115be38379d8b28d7
#ÚLTIMAHORA | El Gobierno de Cuba anuncia el indulto de 2.010 presos.
I’m in the 19th year of private practice and have always made my patients first. I am concierge medicine! @LivingstonMD @ASPS_Members @ASPS_News @AmCollSurgeons @HandSurgeryAssn
@Jikkyleaks
Maybe, just like the evidence suggesting at least three from the Challenger disaster are alive and well, look at this and tell me where the four 'best and brightest' (year right) might be now
R to @DrEliDavid: April Fool's, of course. This pathetic clown would move the French embassy to Gaza before Jerusalem.
Nominal translunar injection burn complete. The Artemis II crew is officially on the way to the Moon.
America is back in the business of sending astronauts to the Moon. This time, farther than ever before.
To what lengths, if any, were Chris Hipkins, the Ministry of Health, and the COVID-19 Vaccine Technical Advisory Group (CV-TAG) willing to go in order to avoid creating vaccine hesitancy?
Just 3 weeks ago an account that appears to belong to David Gollogly — Chair of the Royal New Zealand College of Urgent Care and convenor of the Pandemic Response Committee — posted a response to a 2023 post by Thomas Cranmer (Philip Crump).
“My College raised this myocarditis risk with the MoH around September 2021, some months before the TAG advice. Their response was: no change, so as not to fuel vaccine hesitancy. We negotiated that it would be okay for our doctors to advise young males to rest after vaccination.”
This was months before the CV-TAG’s December notes regarding the myocarditis risk in teenagers. Yet it is seems the risk of potential vaccine hesitancy was already considered to be more important than myocarditis risks and informed consent.
Spätestens ab 65 Jahren, am besten schon ab 50, brauchen wir mehr Proteine – um dem altersbedingten Muskelabbau entgegenzuwirken. Was das für den Alltag bedeutet und wieso wir Ernährung stärker in Lebensetappen denken sollten. https://www.nzz.ch/wissenschaft/warum-proteine-im-alter-wichtiger-werden-ld.1929625?utm_campaign=mrf-twitter-NZZ&mrfcid=2026040369cc600115be38379d8b28d6
Joe Rogan brings up a post claiming that the COVID-19 vaccines caused more American deaths than WWI, WWII, and the Vietnam War combined.
NEW: Trump is considering more changes to his Cabinet, according to four officials.
He has expressed frustration and disappointment with Commerce Secretary Howard Lutnick and Labor Secretary Lori Chavez-DeRemer.
"He's very angry and he's going to be moving people," an administration official told @politico.
No final decisions have been made on Chavez-DeRemer and Lutnick, and Trump has contemplated firing people and then backed off before.
My latest reporting: https://www.politico.com/news/2026/04/02/trump-weighs-more-cabinet-changes-after-bondi-ouster-00856921
Schweizer Franken und SNB: Was die Wirtschaft jetzt braucht https://www.nzz.ch/meinung/starker-franken-wachsam-bleiben-aber-nichts-ueberstuerzen-ld.1927967?utm_campaign=mrf-twitter-NZZ&mrfcid=2026040269cc600115be38379d8b28d5
France surrendered without even trying. Again.
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Das Geschäft mit den gefälschten Unterschriften wurde erst 2024 öffentlich bekannt. Doch Warnungen gab es schon 2019. https://www.nzz.ch/schweiz/unterschriften-bschiss-staenderaete-ruegen-bundeskanzlei-ld.1932287?utm_campaign=mrf-twitter-NZZ&mrfcid=2026040269cc600115be38379d8b28d4
Who’s getting arrested first under the new Attorney General?
Grünliberale Spitzenkräfte wie die Ständerätin Tiana Moser und die Nationalrätin Corina Gredig verzichten. https://www.nzz.ch/zuerich/die-glp-co-praesidentin-nora-ernst-will-fuer-den-zuercher-regierungsrat-kandidieren-ld.1932203?utm_campaign=mrf-twitter-NZZ&mrfcid=2026040269cc600115be38379d8b28d3
Information on childhood cancer burden is crucial for effective cancer policy planning.
A new #GBD study analysed the global burden of cancer in children and adolescents aged 0–19 years.
Explore the findings ➡️ http://spkl.io/6013AFniB @IHME_UW
I'm used to most economists staring at me blankly when I tell them 80% of economics is combinatorial, but apparently the same goes for computer science.
“We did not participate in the revolution to go backwards”
Ein Betreuer soll 15 Kleinkinder missbraucht und gefilmt haben. Nun fordert der Branchenverband einen vertieften Einblick ins Strafregister von Kita-Mitarbeitern. https://www.nzz.ch/zuerich/maenner-in-der-kita-stehen-nach-missbrauchsfall-unter-generalverdacht-ld.1931677?utm_campaign=mrf-twitter-NZZ&mrfcid=2026040269c32581c6c2c13afe68f665
56% OF AMERICANS NOW BELIEVE COVID SHOTS CAUSED MASS DEATHS.
I wonder if this is why Pfizer HALTS COVID shot trial because they can’t find enough people willing to take another booster shot?
Marshal Pétain started collaborating with the Nazis only after France surrendered. Macron is actively supporting the regime even before surrendering.
The last two calamities that investors have traded – pandemic and Ukraine – both found a bottom in equities well before they were over.
That is all I am going to say about that.
Iran Embassy in South Africa: “We are not antisemitic”
Iran Embassy in Zimbabwe: Hold my beer 👇
Muhammad is the most popular name in London, so statistically, the answer is "Muhammad".
One of the largest spills of untreated wastewater in American history happened while an environmental review process held up sewer line repairs because they were studying risks to a flower and a bat.
Just like COVID.
Remember when Stefan Oelrich admitted that the public would never accept a gene therapy as a vaccine?
No problem, they'll just make it so you will.
Thank you to @TomOliverson for being the first elected official with a medical degree to boldly state what many have been thinking: the Covid shots are no longer needed.
Natural and herd immunity are the smarter and safer path forward.
We hope his statement sets the standard for healthcare providers across the country to acknowledge adverse events and protect medical freedom.
Der Musikjournalist Stefan Hentz zeichnet die Lebenslinien des Jazzstars Miles Davis nach. Er beginnt originellerweise mit der Spätphase und führt dann in die Anfänge zurück. https://www.nzz.ch/feuilleton/musik/miles-davis-biografie-zum-100-geburtstag-des-jazzstars-ld.1931182?utm_campaign=mrf-twitter-NZZ&mrfcid=2026040269cc27c1d058012df0bc98b7
Suddenly they take pride in the pre-Islamic Cyrus the great. Just last year their civil registry banned naming babies after that great king!
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