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@Jikkyleaks @njslea RT von @Jikkyleaks 05.03 05:09
No, the fact is; He's in violation of the UCMJ, wearing his uniform as a former Marine to gain access... It's also being said, it's Stolen Valor, apparently several of his medals are fake, didn't earn them.. It appears he's in more trouble than just having a broken hand
@NZZ 05.03 05:03
Die Mayonnaise kam in den 1950er Jahren nicht mit Pathos, sondern in der Tube – und mit ihr ein neues Verhältnis zur Küche. https://www.nzz.ch/panorama/75-jahre-mayonnaise-a-la-francaise-wie-eine-tube-die-schweiz-eroberte-ld.1927495?utm_campaign=mrf-twitter-NZZ&mrfcid=2026030569a6248138899b152280e645
@DrKissler @niusde_ RT von @DrKissler 05.03 04:56
🔴 NIUS-Moderator Norbert Dobeleit begrüßt NIUS-Chefredakteur Julian Reichelt @jreichelt und die beiden NIUS-Reporter Alexander Kissler @DrKissler und Julius Böhm @julius__boehm. 👉 Einschalten und weitersagen! https://x.com/i/broadcasts/1wxWjalVjgkJQ
@JesslovesMJK @klara_sjo RT von @JesslovesMJK 05.03 04:42
So Greece is sending ships to defend Cyprus from the Persians. What year is this again?
@NZZ 05.03 04:39
Nadine Fähndrich setzt nach dieser Saison einen Schlussstrich unter ihre aussergewöhnliche Karriere. Die 30-jährige Luzernerin gibt ihren überraschenden Entscheid zwei Wochen nach dem Gewinn von Olympia-Silber bekannt. https://www.nzz.ch/sport/ski/ski-nordisch-nadine-faehndrich-kuendigt-ihren-ruecktritt-an-ld.1927779?utm_campaign=mrf-twitter-NZZ&mrfcid=2026030569a6248138899b152280e644
@Aufdecker @welt RT von @Aufdecker 05.03 04:26
Krankenkassen erwirtschaften 2025 Milliardengewinn – und drohen dennoch mit Beitragserhöhungen http://to.welt.de/u7vpiCU
@NZZ 05.03 04:12
Ausgerechnet an einer politisch aufgeheizten Berlinale hat eine Parabel über den schleichenden Verlust von Kunst- und Meinungsfreiheit gewonnen. Nun startet der Film im Kino. https://www.nzz.ch/feuilleton/der-gewinner-des-goldenen-baeren-von-berlin-spiegelt-ein-stueck-weit-die-debatten-um-das-festival-selbst-ld.1927274?utm_campaign=mrf-twitter-NZZ&mrfcid=2026030569a6248138899b152280e643
@PhilippMattheis @UmarFarooq_ RT von @PhilippMattheis 05.03 04:02
"We must learn from history, and you cannot play Russian roulette with the fate of millions of people." - Spanish PM Pedro Sanchez, who appears to be first EU leader to be openly challenging the rationale behind the Iran war.
@anish_koka 05.03 03:52
R to @anish_koka: 15/ In this context multiple outlets are reporting the FDA is asking for an impossible comparator arm (10 hour sham brain surgery) based on comments from the CEO of UniQure after their Type A FDA meeting. I can't find any evidence that anyone at the FDA actually said this. @HHSGov spokesperson noted the CEO comments to be a "distortion"
@anish_koka 05.03 03:52
R to @anish_koka: 13/ Bottom line: UniQure ran a trial years ago. It failed. Rather than go back to the science to come up with something that works, they found a comparison (an external control group) that looks favorable and want the FDA to approve based on that.
@anish_koka 05.03 03:52
R to @anish_koka: 14/ Huntington's patients deserve better than a therapy that only looks effective when you compare it against people who never had a procedure. The placebo bar exists to protect them — not to obstruct innovation.
@anish_koka 05.03 03:52
R to @anish_koka: 11/ To be clear: FDA isn't being uniquely harsh here. Roche faced the same standard with its therapy that had a failed result in 2023 — see Roche study in NEJM (https://www.nejm.org/doi/full/10.1056/NEJMc2300400). UniQure is being treated like everyone else.
@anish_koka 05.03 03:52
R to @anish_koka: 12/ Per FDA public comments: FDA does not require RCTs for everything : If you treat a severely ill Huntington's patient and they dramatically improve — full approval is possible without an RCT. But that would require a dramatic, unambiguous signal. UniQure doesn't have that.
@anish_koka 05.03 03:52
R to @anish_koka: 9/ UniQure's explanation for failure of the 1 year randomized data: "the drug just takes longer than a year to work." Fine — but if that's true, why does the external controlled data show a benefit within that same year? You can't have it both ways.
@anish_koka 05.03 03:52
R to @anish_koka: 10/ Did FDA ever promise to accept the external control data as sufficient? No documented promise exists. FDA routinely says "we need to see the data." That's not a broken deal — that's standard practice.
@anish_koka 05.03 03:52
R to @anish_koka: 7/ Why doesn't that count? Because external controls don't experience a placebo effect. Patients who believe they received a life-changing brain therapy will report feeling better. Patients who never had any procedure won't. That gap is the placebo effect.
@anish_koka 05.03 03:52
R to @anish_koka: 8/ UniQure's own data is internally inconsistent. Their 1-year randomized data shows no difference between treatment and control. But their historically controlled data shows a big benefit. How is that?
@anish_koka 05.03 03:52
R to @anish_koka: 5/ UniQure has done this before. They ran a sham-controlled study in 2019. Their product failed to show benefit.
@anish_koka 05.03 03:52
R to @anish_koka: 6/ So where does UniQure's claimed 60–75% benefit come from? Not from a randomized trial. From comparing their treated patients against an external cohort — people who never underwent any procedure at all.
@anish_koka 05.03 03:52
R to @anish_koka: 3/ This isn't new policy. For 20+ years, FDA has required placebo-controlled trials for Huntington's treatments — including trials with fake intrathecal injections and even fake brain injections. You haven't heard of those drugs because they all failed.
@anish_koka 05.03 03:52
R to @anish_koka: 4/ What did FDA ask UniQure to do? Compare their brain injection against a sham intervention — a small nick in the scalp under brief anesthesia. Not 10 hours of surgery. A few minutes. ( I can find no official confirmation from FDA they have asked for a 10 hour sham surgery comparator arm)
@anish_koka 05.03 03:52
The UniQure/FDA Huntington's gene therapy controversy explained : 1/ UniQure is battling the FDA in the press over a placebo-controlled trial requirement for their Huntington's gene therapy. Here's a brief summary. 🧵
@anish_koka 05.03 03:52
R to @anish_koka: 2/ Huntington's disease is notoriously heterogeneous — patients decline at very different rates. It's also a condition where the placebo effect is well-documented. This is exactly why FDA requires placebo controls.
@ClareCraigPath @benwehrman RT von @ClareCraigPath 05.03 03:49
The Genocide of Beauty
@NZZ 05.03 03:41
Wegen der hohen Spritpreise fordern Politiker Erleichterungen für Konsumenten und Unternehmen. Geld dafür dürfte kaum vorhanden sein. Die Kritik richtet sich auch gegen die Mineralölkonzerne. Sie stammt nicht nur aus der Politik. https://www.nzz.ch/international/abzocke-regierungsversagen-jetzt-entbrennt-der-politische-streit-um-den-preissprung-an-den-tankstellen-ld.1927630?utm_campaign=mrf-twitter-NZZ&mrfcid=2026030569a6248138899b152280e642
@tlowdon @andrewbostom RT von @tlowdon 05.03 03:31
San Francisco: Muslim Sadat Mousa arrested Saturday after officers discovered swastikas and antisemitic & anti-gay words painted on a Pacific Heights church. https://www.sfchronicle.com/crime/article/sf-church-hate-graffiti-arrest-21948575.php
@Jikkyleaks @aravindmc RT von @Jikkyleaks 05.03 03:10
Do notice that the idi0t vaxx pushers always try to avoid discussing or debating ANY data point which exposes third rate pharmacovigilance. @Jikkyleaks @carl_jurassic @canceledmouse As an example, that's why you NEVER see them mention CDC hiding foreign VAERS reports. It is completely ridiculous when you think about it. The Biden era CDC, all the while pretending like it was some kind of "gold standard" for vaccine data analysis, had literally stopped publishing VAERS report clinical narratives! That's how you get a situation like this, where someone like Jake Scott MD can just blatantly lie and pretend that all data has been shared https://x.com/aravindmc/status/2029207886665285872
@PhilippMattheis @KobeissiLetter RT von @PhilippMattheis 05.03 03:04
BREAKING: President Trump has brokered a "multimillion-dollar" gold deal between the US and Venezuela, per Axios. Details include: 1. Venezuela's state-owned mining company, Minerven, agrees to sell up to 1,000 kilograms of gold destined for US markets 2. Trafigura will "shepherd" the gold to US refineries under a separate arrangement with the US government 3. The contract calls for 98% final gold content, sources say 4. The deal could be worth more than $150 million The US is eying Venezuela's gold.
@NZZ 05.03 03:02
Zum zweiten Mal ersucht der Stadtrat um eine Fristerstreckung. Das führt im Gemeinderat zu «aufgesetzter» Aufregung und einem «haarsträubenden» Vergleich. https://www.nzz.ch/zuerich/35-stunden-woche-in-zuerich-stadtrat-erhaelt-mehr-zeit-fuer-pilotversuch-ld.1927421?utm_campaign=mrf-twitter-NZZ&mrfcid=2026030569a6248138899b152280e641
@ifihadastick @JCarpenterTN RT von @ifihadastick 05.03 02:56
Good thing the Supreme Court stepped in on Monday night to stop California from violating parental rights. If not for the work of conservative activists and Republicans in the Tennessee General Assembly, this would have been Nashville. In 2021, all nine Metro Nashville Publics Schools board members wore rainbow face masks as they voted to implement a "Gender Support Plan" that would facilitate a child's so-called "gender transition" at school. The school could determine, based on the child's answers to several questions, whether the parents would have any knowledge of the "Gender Support Plan." It matters who governs. It matters who you vote for. It has never mattered more. [Screenshot from The Tennessee Star]
@anish_koka 05.03 02:45
Hospitals employ teams of coders to make patients seem sicker at baseline to adjust their expected mortality because it helps their bottom line/ improve margins. Not fraud. But abuse?
@anish_koka 05.03 02:43
Risk adjusting used frequently by the metric industrial complex is gameable - doesn't work and ultimately harms patients.
@NZZ 05.03 02:42
Das Parlament ist uneins, wie «modern» das Namensrecht sein soll. Die Idee, dass Geschiedene den Namen des Ex-Gatten weitergeben dürfen, ist abzulehnen. https://www.nzz.ch/meinung/neues-namensrecht-es-braucht-keinen-tourismus-mit-dem-familiennamen-ld.1927670?utm_campaign=mrf-twitter-NZZ&mrfcid=2026030569a6248138899b152280e640
@anish_koka 05.03 02:36
Performance metrics and the cost of reporting that's borne by independent physicians.. how it contributes to physicians dropping out of the Medicare program.
@janinisabel @matze2001 RT von @janinisabel 05.03 02:31
Am Mittwoch war @nymoen_ole zu Gast bei Markus Lanz. Entweder ist Lanz ein Lügner oder so unglaublich unklug, und zusätzlich auch noch fies, dass er mittlerweile völlig ungeeignet ist, eine solche Sendung zu moderieren. Quelle WELT: https://www.welt.de/politik/ausland/video69352bd6074aff6076811fd6/mangel-an-soldaten-gewaltsame-rekrutierungen-in-der-ukraine-immer-noch-haeufig.html
@USMortality RT von @USMortality 05.03 02:26
Vaccinated?
@anish_koka 05.03 02:25
Now discussing Doctors and Performance Stats .. https://x.com/DrDiGiorgio/status/2028573232903893058
@anish_koka 05.03 02:16
Great discussion about the difficult decision surgeons have to make to take a patient back to the operating room because of a complication.
@NZZ 05.03 02:13
Mexikanischen Sicherheitskräften ist mit der Tötung von El Mencho ein wichtiger Schlag gegen die Drogenkartelle gelungen. Doch der Triumph könnte von kurzer Dauer sein, denn die Gewaltspirale droht nun erst recht angefacht zu werden. Und das vor der... https://www.nzz.ch/podcast/kartell-krieg-in-mexiko-die-folgen-nach-dem-tod-von-el-mencho-nzz-akzent-ld.1926964?utm_campaign=mrf-twitter-NZZ&mrfcid=2026030569a6248138899b152280e63f
@anish_koka 05.03 02:12
Discussing the great article by @lee_c_zhao on the death of the former Shah of Iran, potentially at the hands of famed surgeon Michael Debakey. https://www.leezhaomd.org/post/the-second-cut-debakey-the-shah-and-the-hubris-of-the-comforting-explanation
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