Heute, 23:15 bei "Markus Lanz": Wir Wissenschaftler sind der Gesellschaft Antworten schuldig. In der #Pandemie gab es folgenschwere Fehlbeurteilungen und persönliche Angriffe statt sachlicher und transparenter Debatten.
https://www.rnd.de/medien/markus-lanz-heute-gaeste-und-themen-am-donnerstag-10-4-2025-27SGYZWPNVC2LERDL7KPDFMWAE.html via @RND_de
Smartes Business-Konzept: Dreck und Seife! 😂
Privately run Medicare Advantage plans will get a sizable payment bump from the federal government, thanks to a 5.06% increase announced by the Trump administration Monday https://www.wsj.com/health/healthcare/private-medicare-plans-to-get-big-payment-boost-from-trump-administration-017d9aaa?st=imNscs via @WSJ
We were so happy to partner with participants on this decentralized, technology-enabled trial. Innovative way to do trials. I just wish the result had been better for patients. @VirusesImmunity @YaleMed @yalediscovers @TheLancetInfDis https://medicine.yale.edu/news-article/does-paxlovid-reduce-long-covid-symptoms-yale-led-trial-finds-out/
Marderhund oder Labor? Hier habe ich die wissenschaftlichen Fakten zum Ursprung der #Covid-Pandemie zusammengefasst. Die Pandemie ist menschengemacht, so oder so. Wir müssen gefährliche Experimente und verantwortungslose Tierhaltung besser kontrollien.
https://www.mdr.de/nachrichten/podcast/kekule-corona/audio-coronavirus-ursprung-laborthese-wuhan-100.html
1/5 🔥 Hot off the press — PAXLC trial results now in @TheLancetInfDis （🇯🇵日本語解説付き）
After 3 years of dedicated work, we’re proud to share results from PAX LC: a fully decentralized, double-blind, placebo-controlled, FDA-authorized Phase 2 trial of Paxlovid (nirmatrelvir/ritonavir) for long COVID across 48 U.S. states (NCT05668091)
✅ 100 adults with long COVID
✅ Randomized 1:1 to Paxlovid or placebo (ritonavir only)
✅ 15-day oral treatment
🎯 Primary outcome: Change in PROMIS-29 PHSS at Day 28 from baseline
Here’s what we found—and why it matters. 🧵👇
Get your free copy here: https://www.sciencedirect.com/science/article/pii/S1473309925000738?dgcid=coauthor
1/5 🔥速報：PAX LC 試験の結果が @TheLancetInfDis に掲載されました！
3年にわたる設計と実施を経て、コロナ後遺症に対するパキロピッドの有効性と安全性を検証した**分散型・二重盲検・プラセボ対照・FDA承認の第2相試験「PAX LC」**の結果を報告します（米国48州対象）。
✅ コロナ後遺症の成人100名が参加
✅ パキロピッドまたはプラセボ（リトナビルのみ）に1:1で無作為化
✅ 経口治療を15日間
🎯 主要評価項目：ベースラインから28日目時点での PROMIS-29 PHSS の変化
ここから、試験結果とその意義を詳しくご紹介します🧵👇
@MitsuakiSawano @bornali_27 @CesarCaraballoC @rohan_khera @jspertus @VirusesImmunity @hmkyale
@YaleMed @YaleIMed @YaleCardiology @YaleCII
#PAXLC #LongCOVID #RCT #Paxlovid
Find our other related materials here:
http://ClinicalTrials.gov : https://clinicaltrials.gov/study/NCT05668091
PAXLC Design Paper: https://www.sciencedirect.com/science/article/pii/S0002934324002717?via%3Dihub
PAXLC Demographics Paper: https://www.medrxiv.org/content/10.1101/2024.11.25.24317941v1
We are hiring a Deputy Editor for The Lancet Regional Health – Southeast Asia
Find out more about the role here
https://lnkd.in/gBEyCJKB
@TheLancet
@GKangInd
@doctorsoumya
@WHOSEARO
@AnuragAgrawalMD
@swarup1972
@vivekkute
@combatstrokeSL
@lakshmivijayku1
HEUTE um 17:00 in der Kaiserin-Friedrich-Stiftung in Berlin: Podiumsdiskussion zur Rolle der Wissenschaft in der Pandemie. Auch dedizierte Maßnahmekritiker kommen zu Wort. Dürfte spannend werden:
https://www.hufelandgesellschaft.de/dachverband/veranstaltungen/podiumsdiskussion-wissenschaft-im-stresstest
Well done to my sister @AnjaSaso on her excellent RCT just published in @TheLancetInfDis looking at effect of #pertussis vaccine in pregnancy
Huge amount of work at @mrcunitgambia 🇬🇲
Proud brother!
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00072-6/fulltext?rss=yes
Do you want to do your #postdoc with the most prestigious #fellowship in Europe? Apply to DKFZ Marie Skłodowska Curie MasterClasses here:
➡️ https://t1p.de/uay9j
Projects in #cancerresearch #genomics #bioinformatics #immunology #medicaltechnology #epidemiology
@HorizonEU
RESISTANCE IN TB AND HIV: Article we just wrote for the @TheLancetInfDis on a consequence of HIV global funding cuts that has not been discussed much -the development of drug resistance in HIV and TB
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00209-9/fulltext
By 2020, ~90% of U.S. teens (12–17) were vaccinated against HPV — with no meaningful difference by race.
But look at cervical cancer mortality since the vaccine’s rollout:
🔺 Asian women: mortality increased
➖ Native American women: unchanged
🔻 Black women: biggest decline
Same vaccine coverage. Different outcomes.
If HPV vaccination drove the drop in deaths, we’d expect similar trends across groups.
Here is our fact sheet on the Genetic Literacy Project and Jon Entine
https://usrtk.org/industry-pr/jon-entine-genetic-literacy-project/
In which we introduce the least known game in game theory, the game that explains (almost) all of civilization: the protector-provider game, aka swords against ploughshares.
An Economic Pattern Language: On Governance, by @oliverbeige. 100% handwritten.
https://econpatterns.substack.com/p/on-governance
Out now in @TheLancetInfDis our #SEMVAc study demonstrates that the MVA-BN vaccine (Imvanex/Jynneos) is safe & effective against #mpox, but a single dose does not sufficiently protect people living with #HIV.
Thank you @EMA_News for support.
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00018-0/fulltext
I was raised in the most perfect place on planet earth- Encinitas California.
Back in the 90s it was surreal. Quintessential crunchy surfer town where everyone drove VW buses and old mustangs to school. It was peak 90s culture- no conspicuous consumption, garage bands, you ditched school to surf.
72 degrees with an ocean breeze year round. Terrible place to be raised because your mental benchmark for weather is perfection.
I spent my single years living two blocks from the beach in HB in the early 00’s. Another idealistic era, where you’re woken up on the 4th of July by your neighbor playing the Star Spangled Banner on the electric guitar, and ended the day watching the fireworks by your bonfire on the beach.
I thought I was going to spend the rest of my life in San Clemente- close to my parents but with Camp Pendleton as a nice barrier. Then I had kids, and I knew it was never going to happen.
I, like millions of others, left California due to Democrat policies. I gave up paradise to live in a society that aligned with my belief system.
My first year in Fort Worth Texas there was 100 days over 100 degrees. You did not want to leave the house it was so hot. You also never walked barefoot on the grass because it was filled with red ants and spiders.
You know what there is to do for fun in Fort Worth? Get on an airplane and go somewhere else. You drive for 8 hours and guess what- you’re still in Texas. Miles and miles of ugly nothing topography.
And you assholes have the audacity to move to our unappealing red states and try to turn them blue?! GO LIVE YOUR SOCIALIST FANTASIES IN PARADISE!!
LEAVE OUR HOTTER THAN HELL BUG INFESTED CONSERVATIVE STATES ALONE.
What’s that you say? You can’t afford to live anywhere on the entire West Coast? Gee Whiz moron. I wonder why that is….
There’s nothing I loathe more than a red state liberal.
Die #Pandemie hat nicht nur Patienten mit #LongCovid, sondern auch ein gesellschaftliches PostCovid-Syndrom hinterlassen. Wie wir das verlorene Vertrauen in unsere Mitmenschen, den Staat und Wissenschaft wiedergewinnen können, habe ich hier besprochen:
https://www.mdr.de/nachrichten/podcast/kekule-corona/audio-corona-aufarbeitung-wuhan-bnd-100.html
When astronauts Sunita Williams and Barry Wilmore return to Earth after nine months, they are likely to have smaller hearts and poorer vision. Here’s how time in space causes physical changes. https://www.wsj.com/science/space-astronomy/nasa-astronauts-return-health-body-changes-c8fdc999?st=AoNk2i via @WSJ
Why does scratching an itch feel so good? There is a surprising benefit—but scientists (and moms) still say you shouldn’t do it. @NidhiSubs reports for #WSJScience https://www.wsj.com/science/biology/scratch-itch-benefits-bacteria-55de60a4?st=7SfNCk via @WSJ
Kekulés Gesundheitspodcast von @MDRAktuell ist heute live um 13:30 bei "Leipzig Lauscht"!
Thema heute: "Was Corona mit uns gemacht hat ". Und: Kam das Virus doch aus dem Labor?
Susann Böttcher und ich freuen uns auf euer Kommen!
https://leipziglauscht.live/
Herr Musk, Sie sind unerträglich.
Lieber Herr Stark, wissenschaftlich haben Sie -und wohl auch der BND-nichts Neues gefunden. Dass das BKAmt das auch sah, ist kein Skandal. Die Sache wird nur zum Aufreger, weil @c_drosten und @DIEZEIT die Laborthese immer tabuisiert haben, obwohl sie wahrscheinlich (>50%) stimmt.
Der heutige @DieZeit-Titel zum #Laborursprung der #Pandemie enthält leider keine neuen wissenschaftlichen Daten. Neu -und gut- ist, dass @c_drosten u. Co. ihre Vorurteile aufgeben.
Die -immernoch aktuellen- Fakten habe ich hier besprochen (13.7.2023!): https://www.mdr.de/nachrichten/podcast/kekule-corona/audio-ursprung-pandemie-labor-wuhan-100.html
What are your favourite papers / trials on duration of antibiotics in febrile neutropaenia?
(For a talk about the ethics of shorter courses of antibiotics for this patient group - thanks in advance!)
@VPrasadMDMPH @Timothee_MD @Eddie_Cliff @ABsteward @BradSpellberg
It has been reported German Intel has assessed that COVID19 originated via a lab leak
Swiss paper NZZ reports that our discovery of a MERS-related infectious clone with a chimeric spike from Wuhan sequencing datasets was considered by German Intel 🧵
Our latest study in @nature reveals how #TGFβ drives Epstein-Barr Virus (#EBV) reactivation in multisystem inflammatory syndrome in #children (#MISC, #PIMS) following #COVID19. @DRFZ_Berlin @Mashreghi_Lab #SARSCoV2 @ChariteBerlin
🔗 Read here: https://www.nature.com/articles/s41586-025-08697-6
Von wegen gut durch die Pandemie gekommen.
Die wenigsten Lebensjahre pro 1000 Einwohner verloren Schweden, Dänemark und die Schweiz.... https://www.focus.de/gesundheit/news/neue-studie-corona-kostete-die-deutschen-2-000-000-lebensjahre_524edc25-dd12-4766-a3c9-646618f7832c.html
What did removing Saddam, Gaddafi, Assad get us? Chaos, civil war, genocide.
The rule for regime change operations in the Middle East is that they don’t flip a country from bad-to-good. They flip a country from bad-to-worse.
A little DST history lesson:
We experimented with year-round Daylight Saving Time (DST) as a response to the 1973 oil crisis, with the change taking effect on January 6, 1974.
The goal was to conserve energy by extending daylight into the evening hours.
This shift resulted in significantly darker mornings during the winter months, particularly affecting schoolchildren who had to commute to school before sunrise.
In Florida, eight schoolchildren were killed in predawn car accidents shortly after the policy began.
The prolonged morning darkness was linked to incidents like a 6-year-old girl in Virginia, being struck by a car and breaking her leg & two students in Maryland, being injured in February.
Which is why permanent DST was abandoned not even a year after its implementation.
Wie sehen Sie die Rolle der Medien in der Pandemie? In meiner Wahrnehmung trugen sie wenig zur Deeskalation bei. Im Gegenteil, das Schüren von Angst und das Heraufbeschwören von Untergangsszenarien ist wenig hilfreich. #corona #covid19 #aufarbeitung https://www.abendblatt.de/hamburg/article408359757/hamburgs-corona-erklaerer-das-war-sicher-der-groesste-fehler.html
Senatsanhörung @DrJBhattacharya, designierter Direktor des National Institute of Health (NIH)!
Zugleich eine gute Zusammenfassung dessen, was die Daten zeigen und was er und andere Warner von Anfang an wussten.
Hintergrund: Als Mitverfasser der „Great Barrington Declaration”, die eigentlich nur Lehrbuchwissen enthielt, aber die Pläne der Vakzinisten durchkreuzte, wurde der Stanfordprofessor in den USA ähnlich diffamiert wie die Proffs. Bhakdi und Hockertz hierzulande.
Bisher kennt der Boulevard Bhattacharya nur als „Drostenhasser”, obwohl er nie ausfällig wurde und sich von @c_drosten öffentlich als Lügner beleidigen lassen musste. Gleich danach tauchte Drosten zwei Jahre ab. Jetzt ist er wieder dar und phantasiert im unsäglichen @ndr, wie viele Millionen Leben er und die anderen Lockdowner und Zwangsimpfer gerettet hätten. Es ist eine Schande, aber in den USA kommt die Wahrheit ins Parlament und auf die Fernsehbildschirme.
Cholera has skyrocketed globally in recent years, linked to factors such as conflict, displacement, and climate change.
A lack of political commitment & investment in controlling cases has also contributed to its resurgence.
Read more in the latest news piece from @TheLancetInfDis ▶️
https://hubs.li/Q039pBC90
No randomized placebo-controlled RCT's for measles vaccine exist. The Cochrane Institute, rates the evidence as only low to moderate certainty, relying solely on confounded observational studies rather than the gold-standard placebo-controlled RCT's which don't seem to exist.
🔥 MEGA ANALYSIS on #Measles #Outbreak: The Recent “Measles Outbreak” Scare Appears to Be a Big Pharma Campaign, Unsupported by Data!
Let's look at actual data & studies. Notably, before the introduction of the first measles vaccine ...
Mega Thread 🧵 1/n
With cholera resurging in recent years, this letter by @SecGTFCC @TheLancetInfDis highlights the crucial principle of adaptive surveillance. It stresses that surveillance must be tailored to different epidemiological contexts, as outlined in their guidance
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099%2825%2900143-4/fulltext
Krebserregenden Viren keine Chance geben: Die #Impfung von Kindern & Jugendlichen gegen humane Papillomviren (HPV) schützt im Erwachsenenalter zuverlässig vor verschiedenen Krebserkrankungen der Geschlechtsorgane und im Kopf-Halsbereich. #HPVAwarenessDay
https://t1p.de/ux7oo
This overdue statement comes only 3 years after the invasion and from the far-sighted leader of a small country. If Europe doesn't act now, we will pay a much higher price in the near future.
Danish PM Mette Frederiksen Speaks About Ukraine https://youtu.be/Ht0H4DeBwDI?feature=shared via @YouTube
Very pleased to share our latest paper in @TheLancetInfDis. This paper considers the complex issues of antimicrobials at the end-of-life, including nonclinical factors that must be navigated in the dying process. Thanks to @BillyRosaPhD for leading this!
https://www.sciencedirect.com/science/article/pii/S1473309924008326
New paper out! Raising ethical questions with uses of metagenomics for diagnosis. @ID_ethics @Ethox_Centre @PSIOxford Read it at: https://doi.org/10.1099/jmm.0.001967