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Then come the random 10% wicks that don't exist on other exchanges just to liquidate users. 📉 #CryptoScam
Do not invest🚨 #Asecoins / #AsecoinsScam are fake trading platforms preying on investors! ❌
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Hey. Looks like my Thursday is gonna be busy. A couple EEs are going to break this down for the audience.
Steve will like the statistics about the US Courts.
I will review the THE ACIP MEMORANDUM.
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R to @FrankfurtZack: 🤓
https://x.com/i/status/2035825127170998315
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"Machtwechsel" auf deutsch: Die SPD bleibt auch nach 35 Jahren in der Regierung in RLP, stellt dann halt zwei Minister oder so weniger.
Das Verhältniswahlrecht ist ein schwerer Designfehler leider.
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UK net migration, visualised as towns and cities
2005: Milton Keynes 🛣️
2006: Luton ✈️
2007: Plymouth ⚓
2008: Swansea 🌊
2009: Colchester 🏰
2010: Aberdeen 🛢️
2011: Portsmouth 🚢
2012: Newport 🌉
2013: Armagh, Banbridge and Craigavon 🏞️
2014: Hull 🐟
2015: Derby 🐏
2016: Nottingham 🏹
2017: York 🏛️
2018: Wrexham 🐉
2019: Newry, Mourne and Down ⛰️
2020: Inverclyde ⛴️
2021: York 🏛️
2022: Edinburgh 🏰
2023: Glasgow 🎸
2024: Coventry ⛪
That’s the scale.
Pro-Iranische Medien (Ursprung: „WW3MEDIAA“) teilen einen Animationsfilm mit dem Titel „Lord of the Straits“ („Herr der Meerengen“), der sich um die Straße von Hormus dreht.
@UsforThemUK @usforthemcymru @TheConWom
The Reckoning We Owe Generation Covid https://brownstone.org/articles/the-reckoning-we-owe-generation-covid/ via @brownstoneinst
The world according to #Narf
If you understand what they did to cell membrane you can only get scared: From my planned IPAK-Presentation:
"Let me briefly summarize where we are now, because at this point we have the two most critical puzzle pieces to understand how membrane organization controls cellular signaling and why LNPs are a real issue with unknown long-term safety potential, an issue that goes far beyond modRNA and Spike Proteins.
First: PIPs, particularly PI(4,5)P2, function as electrostatic organizers of the membrane. They do not just provide substrate for second messenger production. They define where signaling can occur, which proteins can bind, and how signaling platforms assemble spatially.
Second: Signal transduction operates through threshold logic and competitive binding at these PIP-enriched membrane domains. Small perturbations in the electrostatic landscape do not simply reduce one signal. They reorganize the competitive balance across multiple pathways simultaneously.
Now we need to understand how this electrostatic organization translates into biochemical signaling cascades to provide the logic why LNPs will disturb this complete network in unpredictable manor and will change the whole cell behavior. NSP.
Slide 19
This perspective was demonstrated by Zhang and colleagues for Muscarinic-current channels, or KCMQ. We will take a closer look because this illustrates the most critical aspect of how charged lipids control signaling through hard physics. My slide summarizes three studies to provide a holistic picture of how electrostatic membrane properties translate into biochemical signaling interactions.
As Zhang and colleagues showed, if you alter the membrane charge or lipid composition, you don't just reduce signaling. You reorganize where signaling can occur. Receptors are clustered in lipid rafts, and PI(3,4,5)P3 is formed in these localized, charge-dependent regions. Any disturbance reshapes the spatial signaling landscape, and due to feedback mechanisms, small membrane-level changes propagate into large downstream effects.
But there's more. Szentpetery and colleagues demonstrated that PI(4,5)P2 accumulation at the plasma membrane recruits oxysterol-binding proteins like ORP8, which mediate phosphatidylserine-PIP2 exchange between the ER and plasma membrane. This maintains the lipid composition required for membrane organization.
And critically, as Chung and colleagues showed, PI4KIIIα drives the PI4P gradient that controls ORP5/8 function, and through that, controls KRAS localization. KRAS requires phosphatidylserine-rich domains for membrane association. If the PI4P gradient is disrupted, ORP5/8 cannot function, phosphatidylserine distribution becomes dysregulated, and KRAS dissociates or mislocalizes.
Given that even a 25% reduction in KCNQ channel function leads to epilepsy, and that Zhang showed how single amino acid mutations affecting PIP2 binding dramatically increase receptor-mediated inhibition, the system's sensitivity to electrostatic perturbation is evident. And this may become a bigger issue for LNPs than we actually notice and have noticed so far. And this is where I become emotional: We are not dealing with a system that tolerates noise. We are dealing with a precision instrument.
In other words: disrupting the PIP landscape simultaneously reorganizes lipid trafficking, spatial organization of signaling platforms, and the competitive balance of multiple pathways, including both RAS/RAF/MEK/ERK-MAPK and PI3K/AKT/mTOR-complexes. So the question is: if a system fails when there is a 25% malfunction—how many other cellular precision instruments have similarly tight tolerances, and which of them affect LNPs? NSP. "
🚨 BREAKING – US Treasury Secretary Scott Bessent: “We will have 50 days of higher prices for 50 years of no Iran nukes.”
Gordon Schnieder wird wohl neuer Regierungschef in dem südwestdeutschen Bundesland. Der bisherige Amtsinhaber Alexander Schweitzer räumte seine Niederlage ein. Die AfD wurde drittstärkste Kraft und erzielte ihr bestes Ergebnis in Westdeutschland. https://www.nzz.ch/international/die-cdu-siegt-laut-hochrechnungen-deutlich-in-rheinland-pfalz-bittere-niederlage-fuer-die-sozialdemokraten-ld.1930363?utm_campaign=mrf-twitter-NZZ&mrfcid=2026032269bddf81793f935293a7bd93
I'm slightly puzzled about how little some Jewish intellectuals apparently seem to know about antisemitism over the last millennia. Antisemitism predates Christianity, and has taken endless forms, and it has reinvented itself many times. This (those drawings), whatever it may be - legitimate criticisms of Israel or hatred of Jews - is definitely not typical of the nazi Germany brand of antisemitism.
In all the thousands of years of Chinese history a sarbecovirus with a furin cleavage site turned up the year after, and in the same city as, a plan was made to make such a virus.
There are tens of thousands of cities in China,
And tens of thousands of food markets,
But Covid started close to the lab with the world's biggest collection of sarbecoviruses,
And the most active program of manipulating them
That alone is reason for investigating the lab.
Frankreich:
ich lag falsch mit meiner Spekulation zu einer richtungsweisenden Wahl. Die Wahlbeteilung blieb niedrig mit ca. 57%.
Die Bürgerlichen haben sich nicht zwischen Islamogauchisme und RN entscheiden wollen & blieben der Wahlurne fern. Insofern ist dieser letzte Testlauf vor den Präsidentschaftswahlen 2027 nicht wirklich aufschlussreich.
Linksradikale & RN erzielten Achtungserfolge, aber das Land erscheint gespalten ohne klare Richungsentscheidung bei Desinteresse von ca. 40%.
Paris bleibt sozialistisch: ca. 60% links
/linksradikal vs 40% bürgerlich.
Terafab ist das neue
20 Millionen EV/jahr
oder
ROBOTAXI
oder
Full self driving
oder
OPTIMUS
oder
4680 Batteries
oder
Supercomputer
R to @DrKissler: Ministerposten.
R to @rosenbusch_: m.bild.de/unterhaltung/stars…
Eine Allianz von „Promi-Frauen“ für Gerechtigkeit von physischen nicht virtuellen Vergewaltigungs-Opfern der weltweit vernetzen Epstein-Clique, die es nie geben wird, würde die BILD vermutlich nach Möglichkeit diskreditieren.
Unter den Arbeitern hat die AfD in Rheinland-Pfalz einen Anteil von 39 Prozent.
If these surrogates were this clinically relevant with just 26 weeks of therapy.. the three large RCTs that had tens of thousands of patients with 4-5 years of follow up would show a really large benefit with regards to hard events.
You could actually run much smaller trials with much shorter follow up and still see a huge difference between control and treatment arm.
And yet VESALIUS, FOURIER, ODYSSEY show no clinically or statistically significant benefit in heart attack rate.
Which means I would commit zero dollars to any study attempting to use these surrogates as some proxy of clinical outcomes.
This is a junk study. But it is good for Instagram cred.
Global warming is a scam, and this guy proves it by using common sense.
Die CDU gewinnt die Landtagswahl in Rheinland-Pfalz klar. Doch die politischen Lehren, die in Berlin daraus gezogen werden, greifen zu kurz. https://www.nzz.ch/meinung/die-cdu-gewinnt-rheinland-pfalz-und-die-lehren-die-die-berliner-politik-daraus-zieht-greifen-zu-kurz-ld.1930381?utm_campaign=mrf-twitter-NZZ&mrfcid=2026032269b4a50183466856c2826eaf
Israeli settlers smash cars and set fires in the West Bank as 4 Palestinians killed in Gaza http://dlvr.it/TRdlkY
Auch 35-44j wählen Schwarz-Rot. Wir kommen, seit die AfD dabei ist, aus Schwarz -Rot/Grün niemals mehr heraus.
Why does @macmillancancer think I am more vulnerable than a heterosexual man or woman?
What is it about me that @macmillancancer thinks is weak or vulnerable?
Because I think you are bigots.
Das Wahlergebnis ist mehr als ein landespolitisches Ergebnis. Alexander Schweitzer hatte die besten Persönlichkeitswerte, hat gekämpft wie ein Löwe und hat trotzdem nicht gewonnen. Es geht um etwas Grundlegendes. Wenn die Mehrheit in unserem Land glaubt, die SPD kümmere sich mehr um Bürgergeldempfänger als um die hart arbeitende Mitte, dann ist das mehr als ein Alarmsignal. Das kann nicht unser Weg sein. Die Wahrheit ist: Die SPD auf Bundesebene hat ein Problem, wenn es um die eigene Wahrnehmung durch die Bürger geht. Die Menschen glauben uns nicht mehr. Das muss doch jetzt endgültig alle wachrütteln – so geht es nicht mehr weiter!
Ein klarer Fokus auf die Mitte ist Voraussetzung für den Fortbestand als wichtige politische Kraft in Deutschland. Weniger Beachtung für laute und schrille Debatten aus der Hauptstadtblase, maximaler Fokus auf Themen, die die Mehrheit der Menschen tagtäglich tatsächlich beschäftigen: Wirtschaft, Arbeit, Sicherheit, bezahlbares Leben – von den Energiepreisen über Miete und Eigentum bis hin zu den Lebensmitteln.
Die Menschen erwarten von uns Antworten darauf, wovon und wie wir und unsere Kinder gut leben können. Und wir geben ihnen zu viele Debatten zu Nischenthemen. Das muss sich ändern.
In der SPD müssen nun alle verstehen, dass Wahlen in der Mitte gewonnen werden, die Sorgen der Leute ernst zu nehmen sind und wir uns nicht in Klein-Klein-Debatten verlieren dürfen.
Die SPD hat schon den Kaiser und zwei Weltkriege erlebt, hat in Ost wie in West immer auf der richtigen Seite der Geschichte gestanden – wer, wenn nicht die SPD, wäre besser geeignet, um Deutschland sturmfest für die neue Zeit zu machen? Dafür müssen wir uns auf die Mitte der Gesellschaft fokussieren, sonst droht die Bedeutungslosigkeit. #spd #reformen #groko #seeheimerkreis #rlp @EsraLimbacher
UAE’s Foreign Minister @ABZayed calls Iran “terrorists”
R to @JAMA_current: From @JAMANetworkOpen: Variability in #ECMO candidacy selection may result in inconsistent allocation; multidisciplinary review and clear guidelines are recommended to improve transparency and equity.
#SCCM2026
https://ja.ma/4sr4TD9
R to @JAMANetworkOpen: 💬 Editorial: Newly developed surveillance criteria for pediatric #Sepsis enhance case identification and benchmarking but require further refinement for newborns and data capture.
#SCCM2026
https://ja.ma/4bYjy2X
🧵 #SCCM2026 attendees, check out these findings from JAMA and @JAMANetworkOpen:
Among US #pediatric hospitalizations, an electronic health record-based definition identified #sepsis in 1.3% of encounters, with an in-hospital mortality rate of 10%.
https://ja.ma/4smzxO1