BREAKING: BBC faces backlash after altering Pete Hegseth speech – just months after doing the same to Donald Trump
https://www.gbnews.com/news/bbc-pete-hegseth-speech-donald-trump
It's an auto-immune disease, but people love to hear its someone else's fault.
If you’re unvaccinated, did you get sick from Covid 19??!!
R to @rosenbusch_: apollo-news.net/damit-wir-in…
Nichts hat sich geändert, seit sie weg ist. Gar nichts.
„Alternativlos“. Sie hat nicht gelogen.
Vinay Prasad was incorruptible and he was rewarded for that with smears in the press (including a widely broadcast fake sexual harassment accusation) and now a legal threat from a sitting congressman. As corrupt as I knew the FDA was, it’s so much worse than I realized.
The evidence is piling in now that ChatGPT and all the other large language models are on a developmental plateau and hallucinations will never stop.
Not a pathway to exponential improvement or to human level intelligence.
The data centre build is pointless.
Warum war der Dreck den Merz, Klingbeil, Grüne und Co. bisher auf Trump geworfen haben kein Antiamerikanismus?
Den gibt es erst wieder seit nicht alle einen neuen Krieg bejubeln…
Jean-Jacques Rousseau sehnte sich nach dem ursprünglichen Paradies, obwohl er wusste, dass kein Weg dahin führt. Volker Reinhardt schildert das Leben des Philosophen, Dichters und Aussteigers mit allen Widersprüchen. https://www.nzz.ch/feuilleton/vorwaerts-ins-paradies-volker-reinhardt-erzaehlt-jean-jacques-rousseaus-leben-ld.1927528?utm_campaign=mrf-twitter-NZZ&mrfcid=2026030669a8c7810fa22d1c5e6449b5
No viral genome has ever been read in one continuous physical read from start to end - not even with long-read sequencing, although technical feasible, and not even with Sanger sequencing (considered the gold standard). Every published genome is stitched together from overlapping fragments.
Gosh. “Propensity matched” AND “historical control”. That’s bad x bad.
If that’s the bar for approving million dollar therapies, regulation is utterly broken
R to @rosenbusch_: berliner-zeitung.de/politik-…
Wie sehen Sie speziell die deutsche Position? Friedrich Merz war bei Donald Trump in Washington.
Die Pressekonferenz von Trump und Merz hat gereicht, um zu verstehen, wie schwach, passiv und blass Deutschland ist. Merz saß dort wie eine Marionette in einer Show. Die Show war ganz Donald Trump. Merz hatte nichts zu sagen – und er sagte nichts. Selbst als er sprach: Was sagte er? Dass das Regime geändert werden müsse und man über den Tag danach nachdenken müsse. Es hat einfach die Schwäche Europas sichtbar gemacht – gegenüber Donald Trump – und seine Passivität.
Clinical Decisions: Blood-Pressure Targets in Hypertension Management https://www.nejm.org/doi/full/10.1056/NEJMclde2505268
#Cardiology #MedEd
My favorite illustration of the problems with propensity-score matching comes from Facebook
Their researchers had to use a massive set of 3,719 covariates to come close to matching the estimate produced by an experiment they ran
'Yeah, PSM works, just get 3,719 covariates, bro'
Seriously, who puts out bullshit like this, unless paid by some pharma or secret agency?
Unpopular Opinion: I've been trying Openclaw for the last few weeks, and it's pretty useless. A claude agent in plan mode with ga good spec, still ends up being much superior.
HET IS NIET GOEDGEKEURD!!!!!!!
HOOR JE HET EENS VAN EEN ANDER!!!!
The report also claims he was the person who took a photo of Khamenei's body and sent it to Mossad.
_
Yes, trust the "science".
Originally if you had two shots you were not going to get Covid nor die.
Then it was, you may get Covid, but you won't get sick or die.
Then it was, you won't die.
Vaccinated people got sick and died.
Now, it is just take the shots.
Ist es noch zeitgemäss, in Schweizer Kantonswappen männliche Tierglieder abzubilden? Ein Politiker der Grünliberalen schlägt eine geschlechtsneutrale Anpassung des Berner Wappentiers vor. https://www.nzz.ch/feuilleton/politischer-vorstoss-zu-rotem-penis-sorgt-fuer-rote-koepfe-der-berner-wappenbaer-soll-zensiert-werden-ld.1928061?utm_campaign=mrf-twitter-NZZ&mrfcid=2026030669a8c7810fa22d1c5e6449b4
this is good
if we don't care about evidence and let regulation be led by what pharma wants, just gut the entire FDA, let the market decide, and let CMS negotiate prices
i would prefer an fda that approved based on efficacy and safety
absent that, gutting the fda is preferred over this lousy compromise of fake regulation
New song by the Iranian songwriter Reza Mozaffari (with 1M+ followers), titled “What goes around comes around”
🎶
You thought you'd kill the people and that's it
But now all of you who killed our people are being killed yourself
🎶
🚨 Breaking: Multiple bunker-buster bombs were dropped on IRGC's Ahvaz headquarters earlier today, destroying the building compound and the underground bunkers
New Unreported Truths, about the FDA’s Catch-22…
Well, at least we proactively refilled the strategic petroleum reserve before all this.
Oh, wait.
does the gene therapy for HD work?
what is the evidence other than the company being upset?
was it better than the placebo?
not surprised, but disappointed not part of the story
summed up in the closing:
"The agency’s maximal flexibility in Duchenne stands in stark contrast to the way Huntington’s patients are being treated..."
that DMD therapy had horrible evidence and killed young boys without benefit
That reeks of desperation ...
Die finnische Regierung vollzieht eine nukleare Kehrtwende. Das bedeutet aber nicht, dass im nordischen Land Atomwaffen stationiert werden. https://www.nzz.ch/international/finnland-gibt-sein-rigoroses-atomwaffenverbot-auf-ld.1928158?utm_campaign=mrf-twitter-NZZ&mrfcid=2026030669a8c7810fa22d1c5e6449b3
Tristan (@SharkStats ) is on target.
Approving a $3million/pop gene therapy drug that requires drilling into the skull and a brain injection should be based on... checks notes... a propensity score matched historical control arm. (If you can't appreciate the insanity of this sentence, you should comment zero times about science and evidence)
That is exactly what the biotech/investor community who cares so much about Huntington's disease patients would base approval on.
And then comes the surrogate data. It takes a few minutes of reading to understand how incredibly flimsy that is in the case of Huntington's disease.
The Roche/Genentech product tominersen you haven't heard of that failed was also very promising because it decreased a key surrogate biomarker: mutant huntingtin (mHTT) levels in CSF. But when the Phase III GENERATION HD1 trial ran, lowering mHTT didn't translate to clinical benefit.
The failure was particularly alarming precisely because tominersen did lower mutant huntingtin levels — the surrogate worked — but patients didn't benefit clinically. In fact, patients receiving the drug more frequently actually did worse than placebo.
From the GENERATION HD1 data:
The every-8-week group (higher exposure) showed:
cUHDRS scores significantly worse than placebo (–0.54 points, p=0.001) — this is a composite of cognition, motor function, and functional capacity, trends toward worse Total Functional Capacity (TFC) scores, and elevated CSF NfL at week 21 — suggesting active neuroaxonal damage was occurring.
So now since we can't use mHTT as a surrogate -- we have another unvalidated surrogate --
NfL (neurofilament light chain) is a marker of neuroaxonal damage/neurodegeneration. It's validated as a marker of injury, meaning it rises when neurons are damaged, correlates with disease severity and progression rate across multiple neurodegenerative diseases (HD, MS, ALS, Alzheimer's), and tracks with known disease milestones
But same issue with mHTT : it's validated against disease activity, not against treatment response leading to clinical outcomes. So we know high NfL = more neurodegeneration, we know NfL falls with some treatments, but we have zero robust proof that drug-induced NfL reduction → clinical benefit.
So of course we should get excited about nFL changes and scream bloody murder when someone asks to actually do an RCT to make sure we aren't hurting people, and are paying for something that actually has benefit.
Finerenone improves kidney and cardiovascular outcomes in patients with chronic kidney disease and type 2 diabetes, but its efficacy in type 1 diabetes is unknown. The phase 3 FINE-ONE trial involving patients with CKD and type 1 diabetes is summarized in a new Quick Take video. https://www.nejm.org/doi/full/10.1056/NEJMdo008389
President Trump, 15 years ago 👇
PROMISES MADE. PROMISES KEPT.
_
Hi @elonmusk,
Either X is available in hell as well and Khamenei is posting himself, or someone is impersonating him in violation of X rules.
If it's the former, congratulations, huge achievement by X! If it's the latter, shouldn't the account be suspended?
Bayer has settled prior Roundup cases for ~$11B (nearly 100k claims) and proposes up to $7.25B more over 21 years for current/future ones. Their statement: actions "solely to contain the litigation" for "financial certainty" & to focus on business—no admission of liability or wrongdoing. They cite EPA/EU regulators' conclusion (extensive science: safe when used as directed, not carcinogenic) vs. jury uncertainties in mass torts. Standard strategy to cap exposure.
Der deutsche Konzern kauft die britische Traditionszeitung für 600 Millionen Franken. Damit geht eine lange Phase der Unsicherheit zu Ende. https://www.nzz.ch/wirtschaft/axel-springer-uebernimmt-den-telegraph-und-vereitelt-damit-einen-eingefaedelten-deal-mit-dem-daily-mail-eigentuemer-ld.1928127?utm_campaign=mrf-twitter-NZZ&mrfcid=2026030669a8c7810fa22d1c5e6449b2
When I predicted the rise of the Woke Right, I didn't actually think they'd all lose their minds so publicly like the left did
The left's wokeness exposed it self because of TDS
On the right, the catalyst turned out to be antisemitism...it got outed by Jew Derangement Syndrome
Welcome home General Qaani 🫡🇮🇱